Headaches - Part II Flashcards
Clinical Manifestions: Onset - 3-40 y/o, usually puberty F:M - 3:2 Family Hx - (+) for 70% of cases Etiology - probably genetic; associated with a locus on chromosome 19
Migraine
Any transient neurologic disturbance lasting 15-30 minutes preceding the headache; may be visual, aphasia, vertigo, thick speech, tremor, unilateral numbness or weakness, auditory hallucinations, olfactory hallucinations
Aura (associated with classic migraine)
Spots in front of eyes
Scotomata
Luminous appearance before the eyes, with a zig-zag, wall-like outline; also called a fortification spectrum or scintillating scotoma
Teichopsia
Many migraine patients have feelings of size distortion, called ______ and ______.
…micropsia…macropsia…
Describe the headache portion of a migraine with aura.
Aura ends as throbbing headache begins. Onset is unilateral, but may spread to entire head. Commonly associated with nausea, vomiting, photophobia, sonophobia, pallor, tremors, perspiration, chills. Patient looks sick.
Constipation, diarrhea, cold extremities, local or general edema, speech difficulties, ataxia, dysuria, and impaired consciousness are all less common symptoms of what?
Migraine with aura
Apshasia, extremity weakness, and other focal neurologic deficits are all rare symptoms of what?
Migraine with aura
How long can a migraine with aura last?
Are there any variations to this?
4-24 hours
Variant called Status migrainosus can last up to 10 days
25% of patients will experience the following symptoms preceding what condition?
Elation, irratability, depression, hunger, thirst, drowsiness
Migraine with aura
Describe the post-headache stage of a migraine with aura.
Head on side of attack is tender to touch; brushing hair may be extremely painful. Patient feels exhausted and needs to avoid regtriggering of throbbing head pain. May experience euphoria when pain is gone.
Sudden sharp head pains the last only a second or two when between migraines with aura are called what?
Ice pick headaches or cephalgia fugax
No aura, throbbing character, hemicrania or generalized, and commonly associated with nausea, vomiting, photophobia, sonophobia, pallor, tremors, perspiration, chills. Patient looks sick. What is this?
Migraine without aura (common migraine)
What is the duration of a migraine without aura?
4-24 hours
Describe the post-headache stage of a migraine without aura.
Head on side of attack is tender to touch; brushing hair may be extremely painful. Patient feels exhausted and needs to avoid regtriggering of throbbing head pain. May experience euphoria when pain is gone.
Which cranial nerve is involved with migraines?
Trigeminal n.
Explain the trigeminal vascular reflex.
Afferent stimulation of pain centers in spinal nucleus of trigeminal nerve increases and perpetuates cycle of parasympathetic dilation of internal and external carotid arteries mediated via the facial nerve, resulting in stimulation of pain centers by trigeminal nerve afferents.
Where does the vascular theory of migraine come from?
During brain surgery a conscious patient observed the onset of a migraine and the surgeon observed the vasoconstriction then vasodilation accompanying the headache.
What are 4 problems with the vascular theory of migraine?
Fails to explain premonitory features of attack
Some drugs have no effect on vasculature
Not supported by new blood flow studies (no correlation to aura)
Most patients do not have aura
What is the serotonin theory?
Spreading wave of abnormal neural activity that creeps across the cortex, beginning in the occipital lobe, has been observed. Spread involves most or all of cerebral cortex.
What are the most effective abortive medications according to the serotonin theory? Where are they most active?
Triptans - active at 5-HT1 receptors
What appears to be the final common pathway for migrainous cephalgia?
Activation of 5-HT receptors
Auras have been found to stem from what? What is this?
Cortical spreading depression - a wave of excessive signaling across large areas of the brain, followed by abnormal silence in the previously overactive areas
Name 3 atypical migraines.
Ophthalmagic, hemiplegic, basilar artery
Patient presents with CN III palsy, paralysis of extraocular muscles, and ptosis & pupillary asymmetry lasting days (maybe weeks). What is this and what can it mimic?
Ophthalmagic migraine - mimics carotid artery aneurysm (requires angiography or MRA)
Patient presents with sudden hemiparesis and confusion accompanying sudden onset of headache (other symptoms can include hemiplegia and aphasia). Headache lasts less than an hour. What is this and what can it mimic?
Hemiplegic migraine - mimics transient ischemic attack (TIA)
What is the familial incidence of hemiplegic migraine?
98% of cases (chromosome 19 locus)
20 y/o female patient presents with vertigo, tinnitus, visual blurring, and bilateral paresthesias accomanying headache (other symptoms can include diplopia, dysarthria, ataxia, syncope, stupor, and unilateral paresthesias). What is this and what can it mimic? What work up does it require?
Basilar artery migraine - mimics Wallenberg Syndrome
Requires work-up for vertebral basilar artery insufficiency
How can you prevent migraines?
Identify and remove triggers
Consider prophylactic pharmeceutical treatment if >2 headaches/month
Remember that migraines = neurological events associated with high risk of stroke now and later in life
What are some locations of somatic dysfunction associated with migraine triggers?
Upper 4 thoracic/costal segments - often T4ERrSr or rib 4 (inhaled or exhaled)
Less commonly - cranial somatic dysfunction (occipitomastoid suture dysfunction with partial internal jugular obstruction)
What are the principle sympathetic levels fore vasomotor control of the head and neck?
T1-T4(6)
What techniques should you avoid during an acute migraine attack?
HVLA & ME