Headaches Flashcards
What are two important questions in neurology?
How long have you had this? Sudden or gradual?
Acute
now (1-2 days)
Subacute
Recent (2 days-3 weeks)
Chronic
Months to years
Remote
A long time ago
How to characterize a migraine and the timeline?
Most common HA.
Prodrome> Aura> HA> Postdrome.
“Miserable”.
Sxs of migraines
Typically lateralized, bounding, lasts all day. +N/V.
+/- Aura
What is an atypical migraine?
Migraine with different characteristics. Typically without aura. “Weird”
What gene is thought to be exaggerated in people with migraines?
CGRP (people with migraines have increased CGRP)
Calcitonin gene
Related to protein signalling- thought to be exaggeratedin migraines. Calcitonin is a neuropeptide that signals pain in the trigeminal nerve (CN V= sensory nerve of face)…Calcitonin peptide is increased during migraine and decreases when migraines stop.
What is a recent new tx for migraine?
Block calcitonin gene related to peptide receptors»_space; meds block calcitoin GRP receptors
What are abortive meds for migraine?
=stops HA’s.
OTC= ibuprofen (hard on kidnesy and stomach), Tylenol (tough on liver).
Serotonin R ant’s: Triptans= Vasoconstictors (avoid in MI/Stroke. Causes paresthesia). Ergot (vasoconstrictor, some nausea, often given with antiemetics).
Butalbitals: Pain killer (ex.Fioricet)= works like ETOH/addictive, sedation (great for ppl with bleeding issues)
What is good for treating migraines in ER situations?
1) Ketorolac/Toradol = ibuprofen type (hard on kidneys and stomach).
2) Benadryl= antihistamine (puts ppl to sleep).
3) Compazine= nausea medications, dopamine receptor antagonist (like haldol, can cause tardive diskinesias)
Why should you not give migraine meds (triptans/ergots) to patients with a hx of stroke or MI?
They are vasoconstrictors and cause blood clots
Medication overuse headaches
Using too many migraine meds can cause migraines! If you use any meds more than twice per week, it can trigger HA’s (tylenol, ibuprofen). Opiates give you rebound HA’s (esp. Morphine)!
Tx: try medrol dosepack and taper off medication.