Headaches Flashcards

1
Q

Red flags for headaches

A

First or worst

Abrupt onset

Fundamental pattern change

New headache pattern when

– ≤5 years old

– ≥50 years old

Cancer, HIV, pregnancy

Abnormal physical exam

Neuro symptoms ≥ one hour

Headache onset:

– with seizure or syncope

– with exertion, sex or valsalva

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2
Q

Comfort signs for headache

A

Normal physical exam

Stable pattern
Long-standing history
Family history of similar headaches

Consistently triggered by:

– Hormonal cycle

– Specific foods

– Specific sensory input: Light or Odors

– Weather changes

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3
Q

large meta-analysis reports that 0.18% of patients with migraine and normal Neurologic

exam will have significant intracranial pathology, this means

A

we have Secondary headaches that are a presentation of something else, make sure to do proper workup of headahe

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4
Q

Headache is idiopathic with no identifiable underlying pathology

No diagnostic test

Defined by clinical symptomatology

Diagnosis based on ruling out pathology

A

Primary Headache

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5
Q
  • Headache is symptom reflecting underlying pathology
  • Diagnostic tests available
  • Diagnosis based on defining pathology
A

Secondary headache

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6
Q

Causes of Primary headache

A
  • Migraine
  • Cluster
  • Tension-type
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7
Q

Causes of secondary headache

A
  • Traumatic (e.g. TBI) • Vascular (e.g. SAH) • Infectious (e.g. sinusitis)
  • Metabolic (e.g. CO poisoning)
  • Oncologic – Primary – Secondary
  • Inflammatory (e.g. Giant Cell Arteritis)
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8
Q

What do all the below structures have in common?

Meningeal arteries
Proximal portions of the cerebral arteries

Dura at the base of the brain
Venous sinuses
Cranial nerves 5, 7, 9, and 10, and cervical nerves 1, 2, and 3

A

Pain sensitive intracranial structures

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9
Q

Pt comes in with recurrent migraines, normally DO NOT get CT or MRI unless:

A

– Recent change in headache pattern

– New onset seizures
– Focal neurologic signs or symptoms

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10
Q

____of Headache Seen in Primary Care Practices (PCP) Medical Offices is Migraine and ____of Patients in PCP Waiting Rooms have Migraine with _____ of migraneurs undiagnosed

A

~75%

33%

50%

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11
Q

_____ Women has Migraines
____ Households has a Migraine Sufferer

A

1 in 5

1 in 4

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12
Q

These types of headaches are brief: may see 1 every other day up to 8 per day and are SEVERE, Unilateral orbital/supraorbital/temrporal and last 15-180 mins

A

Cluster headaches

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13
Q

Cluster headaches have characteristic UNIlateral orbital/supra/temporal headahce for 15-180 mins and one of which types of symptoms

A

Conjucntival injection, miosis, ptosis, lacrimation, eyelid edema, rhinorrhea, congestion, forehead/face swelling

so bacially weird eye/nose/face stuff

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14
Q

We may see pain around one eye, along with drooping lid and tearing or conjestion on same side as pain

A

Horner sydrome associated with Cluster headaches

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15
Q

To be Dx with headaches without aura, you must have at least 5 of them, they last 4-72 hrs and have two of the following:

A

unilateral location

pulsating quality

moderate or severe intensity

aggravated by walking up stairs/physical activity

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16
Q

You must have at least ONE associated symptom to have dx of migraine w/out auras. These are:

A

Nausea

vomitting

photophobia/phonophobia

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17
Q

What three features are most predictive of diagnosis with migraines

A

Nausea

disability

photophobia

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18
Q

What is a fortification specra with partial scotoma

A

fancy way to describe aura that sometimes preceeds migraines

last 15-20 mins, sometimes see brief seizures; all aura have + visual elements thus its a HYPERexcitable state

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19
Q

To be Dx with tension-type headaches, you must have a head that lasts

A

hours or may be continous

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20
Q

We need two descriptors of tension headaches to dx; what are they?

A
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21
Q

What associated findings are seen in tension headaches?

A

no more then ONE!!!

photo/phonophobia

mild nausea

**no moderate or severe nausea nor vomitting

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22
Q

Weird way to describe tension headache

A

 Stress as associated event
 Location: Tension Headache as Premonitory Symptom
If neck pain 82% get Tension Headache diagnosis
75% reported neck pain with their migraine
 43% described neck pain as bilateral and 57% as unilateral
 69% described the neck pain as “tightness” and 17% as “stiffness”

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23
Q

How does someone truly suffer from sinus headache?

A

need to have fully filled sinus and congestion

**migrains will cause nasal stuffiness and pressure before treatment

*people may think they have sinus headache when it is migrain and will experience some symptom relief from decongestants bc tx syptoms of migraine

24
Q

What do we need to consider when dx sinus headache

A

location, autonomic symptoms, weather as trigger and OTC advertisement

25
Q

Non modifiable risk facotrs for chronic daily headache

A

migrain

female sex (estrogen)

low education

low socioeconmic class

head injury

26
Q

What are MODIFIABLE risk factors for chronic daily headaches

A

Attack frequency

Obesity

Medication overuse

Stressful life events

Snoring (sleep apnea, sleep disturbance)

27
Q

42 year old male presents with complaint of sinus headache

Current headache problem has been recurrent every night waking patient from sleep

Pain is in left eye and feels “like a dagger”

Has intense nasal congestion leading to rhinorreha as well as a red eye that tears profusely.

Pain last 30 minutes. He thinks nasal sprays help

  • He had similar headaches last December which went away after a month on antibiotics.
  • His PMH/PSH/FH are unremarkable. He drinks socially but has stopped since these headaches began because of “hangover” as soon as he imbibes.
  • PE: unrmarkable, no intranasal findings, no percsussion tenderness

correct dx??

A

CLUSTER headaches

28
Q
  • 31 year old female presents with complaint of headaches that “won’t go away”
  • Had occasional headaches like these for years. Never “big deal” as came and went and rarely required medicine.
  • 6 months ago the headaches became increasingly frequent and longer lasting until they became constant.
  • Denies any other symptoms with these headaches
  • PMH/PSH/FH unremarkable. SH-began working for EPIC 7 months ago.
  • ROS: has developed insomnia and “too tired” to go out with friends or exercise.

OTC meds afford no relief. Sometimes a glass of wine seems to help.

Exam: Negative except for subocciptial tenderness and increased muscle tension in Trapezius and Cervical Paraspinal muscles

DX

A

chronic tension type headache

29
Q

Proposed mechanism for Migraine initiation

A

Genetic susceptibility

Cortical neuronal hyperexcitability/// abnormal brainstem fnx

30
Q

What leads to cortical spinal depression which causes Actvation and peripheral sensitization of TGVS

A

Cortical neuralonal excitability cauases cortical spinal depression (which can lead to aura)

31
Q

What plays a role in pain generation/perpetuation in headaches

A

Neurogenic inflammation and central sensitization as a result of TGVS activation and sensitizaiton (from corical spinal depresion)

32
Q

Mechanism for Hyperexcitability

A

Enhanced release of excitatory neurotransmitters

– For example, elevated plasma glutamate concentration in patients with migraine

– Identified genetic mutations in Familial Hemiplegic Migraine (FHM)

• Reduced intracortical inhibition

Low brain Mg2+

Altered brain energy metabolism

33
Q

Initiating Mechanisms of Headache Pain: Cortical Spreading Depression

A

 Wave of intense cortical neuron activity
– ↑rCBF

 Followed by neuronal suppression

– ↓rCBF

– Often coincides with headache onset

34
Q

What is responsible for Activation of the Trigeminovascular System and Pain Generation

A

Cortical spreading depression: releases AA, NO, H+ and K+ to meninges

get sensitized pain respons adn dilation of vessels

35
Q

Initiating Mechanisms of Migraine: Brainstem Dysfunction

A

Dysfunction in areas involved in central control of nociception *** PAG

Induces migraine? ****Brainstem generator

Facilitates activation and sensitization of TNC neurons? **** Decreased descending inhibition during a migraine attack

36
Q

Migraines can be a result of brainstem dysfnx

What facilitates activation and sensitization of TNC neurons?

A

**** Decreased descending inhibition during a migraine attack

37
Q

Abortive Pharm for migraines

A

Triptans = Key for Abortive: includes Seratonin/ CGRP and Neurotransmission= major class

Hormonal manipulation: such as estrogen and NSAIDS

38
Q

Mechanism of Triptans

A

Seratonin 1B/1D agonist, ≠release of vasoactive peptides such as CGRP, promte vasocnx, ≠brstm pain path, ≠trigeminal nucleus caudalis

39
Q

Side effects of Triptans

A

Sides = periph vasocnx/ nauseua/vomit/angina/flush/dizzy

Contraindication:stroke and MI, uncontrolled HTN, ischemic heart disease

40
Q

Prophy drugs for migraines

A

TCA, Beta Blockers, anti-seizure agents, BP type drugs, estrogens

41
Q

TCAs used to treated migraines prophylactically

A

Amitryptyline, Nortirptyline

42
Q

Facilitate sleep; sedating. Are anticholinergic and effective for many pain sources; Block reuptake of serotonin and Nepi

A

Amitryptyline, Nortirptyline

TCAs

43
Q

Divalproex Sodium and Valpoic Acid, Topiramte

A

Anti-seizure meds to proph tx migraines

44
Q

Vasoactivce compounds use to proph tx migraines

A

Beta blockers: Propranolol, Atenolol = A level and very effective

Ca+ channel blockers: verapamil, Dlitazem; possibly effective

45
Q

Serotonin formation

A

Tryptophan –>(tryptophan hydroxylase as RLS)–>–> serotonin. Trypto.hydroxlase needs O2 and reduced pteridine cofactor; also limited by tryptophan entry into brain

46
Q

Serotonin reactivation:

A

Active reuptake via SERT/ metabolized to 5-hyroxoindole acetic acid via MAO and converted to melatonin in pineal gland via hydorxindole-O-methyl transferase

47
Q

Serotonin dispersment in the body

A

90% in GI system—some in neurons, 8% in plats and 2% in CNS; midbrain raphe nucleus projects all over brain; turnover w/in 4 hours

48
Q

Descirbe Serotonin Receptors

A

Most GCPR except 5HT3 = ligand gated Cation channel

49
Q

Inhibition of adenlyate cyclase; 5-HT1a also opens K+ channels

A

5HT-1a-e

50
Q

Serotonin R that works via PI hydrolysis

A

5-HT2 (a-c)

51
Q

Serotonin R that works via: Activation of adenylate cyclase or unknown

A

5-HT 4-7

52
Q

Auto receptors that Decrease serotonin release

A

: 1A and 1D like

53
Q

Serotonin effecs on CV system

A

Potent vasoCNX of large art/vns; cranial 5-HT1D blood vessels

vasoDIALATIOn in coronary, skeletal msl, cutaneous

Bezold-Jarish reflex = coronar chemoR; lead to hypotension, hypovent, brady

Plat aggregation: active uptake serotonin from circulation by plats

54
Q

Serotonin and CNS system

A

NTs: cell body in midbrain raphe nuclei project rostrally and caudally

Sensory perception/slow wave sleep/temp regulation/neuroendo= ACTH,GH, prolact,TSH,FSH,LH release/ learning+memory + short term/ pain perception/ drug abuse

55
Q

_____= emisis receptors

Has mental illness implications; anxiety =______

A

5-HT3 =

5-HT1A

56
Q

5-HT1A partial agonist for antianxiety

A

buspirone

57
Q

5-HT1B/D receptor on cerebral BV to tx migraines and stop exsisting

A

Sumatriptan