Headache Flashcards

1
Q

Headache caused by mutation in ion channels

A

Familial hemiplegic migraine

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2
Q

Alterations in membrane excitability predispose to HAs (V-gated Ca and Na channels)

A

Familial hemiplegic migraine

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3
Q
This HA has at least 2 of the following: 
UL pain 
Throbbing 
Worse w/ mvmt
Mod-Severe intensity 

And 1 of:
N/V
Photophobia/Phonophobia

A

Migraine

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4
Q
Tension 
Migraine
Idiopathic stabbing
Exertional 
Cluster
A

Primary HA

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5
Q
Head injury 
Systemic infection 
Vascular d/o 
Brain tumor 
Subarachnoid hemorrhage
A

Secondary HA (caused by external force)

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6
Q

Cranial structure that produces pain?

A

Dural sinuses*

Scalp, dural sinuses, middle meningeal artery, falx cerebri, and proximal segments of large pial arteries

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7
Q

Most common type of primary HA?

A

Tension HA 69%

Migraines only 10%

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8
Q

Most common sx with severe migraines?

A

Nausea 85%

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9
Q

Triptans are agonists of which receptors?

A

Serotonin (5HT1b and 5HT1d)

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10
Q

Grouping of primary HAs including cluster HAs, paroxysmal hemicrania, SUNCT (short-lasting UL neuralgiform HA attacks w/ conjunctival injection and tearing), SUNA (short-lasting UL neuralgiform HA attacks w/ cranial autonomic sxs), and hemicrania continua

A

Trigeminal automonia cephalalgias

Migraines w/ aura are not included
Pts often misdx as sinus HA and given decongestants which do not help

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11
Q

Lacrimation, conjunctival injection, nasal congestion

A

Cranial autonomic sxs

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12
Q

Treatment of choice for paroxysmal hemicrania

A

Indomethacin

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13
Q

Effective tx for cluster HAs

A

Verapamil

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14
Q

Most migraine sxs can be induced by dopaminergic ____________

A

stimulation

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15
Q

Ppl with migraines have dopamine receptor

A

hypersensitivity

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16
Q

Pathway for pain in migraines:

Trigeminovascular input from _______________

A

middle meningeal vessels

17
Q
Trigeminovascular input from middle meningeal vessels 
===
Trigeminal ganglion
=====
Second order neurons of \_\_\_\_\_\_
A

Trigeminocervical complex

18
Q

Innervation of large intracranial vessels and dura matter done by which CN?

A

Trigeminal nerve

Trigeminovascular system

19
Q

Preventative med for migraines

A

Propranolol

20
Q

Acute tx for migraines

A

Sumatriptan

Metoclopramide

21
Q

Preventative med for cluster HAs

A

Verapamil

22
Q

Most effective tx for preventing short-lasting UL neuralgifrom HA attacks with conjunctival injection and tearing (SUNCT) is

A

Lamictal

23
Q

5HT1B/1D receptor agonists
Dopamine receptor antagonists
NSAIDs

A

Classes of drugs that tx migraines