Headache Flashcards
1.What are the primary types of HA’s (3) and what are the sx’s and how would they display ?
- Secondary types? (3)
- What are some labs to rule out a secondary headache?
- Migraine (pain, nausea, and visual changes)
-Tension (pain is like a band squeezing the head)
-CLuster (pain is in and around one eye) - Trauma, Vascular, CNS infection
- Thyroid function , serum chemistries, urine toxicology, lyme studies, CBC, ESR , HEAD CT
Migraine without Aura (Common Migraine)
- How many episodic attacks
- Lasting how long ?
- With any 2 of the following ? (4)
- Any 1 of the following DURING HA
Migraine WITH AURA (Classic migraine) :
- How many attacks not attributed to another disorder?
- Aura with >=1 of the following but NO MOTOR WEAKNESS : ?
- Headache begins during ___ or follows within ___
- > =2 of the following (3)
- > = 5 episodic attacks
- 4 hrs - 3 days (untx or unsuccessfully treated)
- Unilateral, pulsating, worsened or caused by movement , moderate or severe pain
- Nausea and or vomiting
-Photophobia and or phonophobia - > =2 attacks
- Fully reversible visual, sensory, or speech sx’s with positive or negative features
- Aura, 60 mins
- > =1 aura sx develops gradually over 5 min
=1 aura sx is unilateral
Individual aura sx’s lasts >= 5 mins but <= 60 mins
Migraine Triggers :
- SLeep?
- S
- Emotional let down
- Missing ___
- D
- A
- M
- W C
- S
- S P
- F
- Too much or too little sleep
- stress
- meals
- dehydration
- alcohol
- medications
- weather changes
- smoking
- strong perfumes
- foods/preservatives
NON-Pharm TX
- SEEDS
- Apply __
- Stop ___
- Caffeine limit to ?
- Alcohol limit to ?
- Improved ___
- Regulation of ___
- Lose ___
- Massage (for tension type)
- Sleep , exercise, eat, diary, stress relief
- ice
- smoking
- 8oz/day
- 1 bev per day
- hydration
- hormones
- weight
Migraine TX Overview
1) For abortive tx mild mod
2) for abortive tx mod- severe
3) for Prophylactic
4) Adjunctive
See chart for tx algorithm!
- NSAIDS, tylenol, combos
- Triptans, Dihydroergotamines , Selective serotonin AGONISTS, CGRP antags
- BB, anticonvulsants, antidepress, long acting triptans, anti CGRP MABS and CGRP antags
- Antiemetics
NSAIDS/APAP/COMBOS
1) WHat are some pros
2) Cons?
- Check chart for dosing!
- Effective for mild/mod pain , prophylaxis in predictable migraines (menstrual), Available OTC, quick onset
- Overuse headache , not effective for SEVERE migraines
Triptans
1) MOA?
2) Prevents peptide release that would lead to ?
3) Sumatriptan Oral dose?
4) SQ dose?
5) Nasal spray?
6) nasal powder?
7) Combo ?
- Serotonin receptor agonist (5HT1B and 1D)
- Vasodilation , neurogenic inflamm, pain
- 25-100 mg x 1, may repeat in 2 hrs (max 200 mg /day)
- SQ 6 mg, may repeat in 1 hr (max 12 mg/day)
- 5-10 mg , can repeat in 2 hrs (max 40mg/day)
- 22mg , may repeat in 2 hrs (max 44mg/day)
- Treximet (85 mg suma + Naproxen 500mg)
- Which triptans are available ODT?
- Available Nasal sprays ?
- Nasal inhaltions?
4.Sq?
5.What’s poor about Sumatriptans oral form ?
- Frovatriptan has a long half life, which may lower recurrecne at 24 hrs –> may be useful in ?
- Which triptan has a slightly faster onset ? –> Which drug does this interact with ?
- Which triptan has CYP3A4 interactions?
- For all the triptans, check for what kind of interactions?
- Rizatriptan, zolmitriptan (must handle with dry hands)
- Sumatript, zolmitriptan
- Sumatriptan
- Sumatriptan
- POOR BIOAVAIL
- prophylaxis or with slow onset HA , good for menstrual migraine prophylaxis
- Rizatriptan –> propanolol (start with 5 mg dose)
- Eletriptan
- MAO interactions
Triptan Major ADR’s and Precautions
- AE’s : F, D, C,S,N , R
- precautions : C,C, history of ___
uncontrolled ___
Concurrent ___ or ___
Use of ____ within 2 weeks (Except eletriptan, frovatript, naratript)
Concurrent ____ /___
Preg category C! - Triptans are best when taken at ?
- Fatigue, dizzy, chest discomfort, somnolence, nausea , rebound HA
- cad, CHF, MI
- HTN
-Ergotamine or DHE
- MAOI’s
-SSRI/SNRI - Onset of pain rather than onset of aura
Triptan Non-Responders
1) What are some alts?
2) Switch to ?
- Just try a diff triptan !
- CGRP antag or lasmiditan
Lasmiditan (Reyvow)
1) MOA?
2) Dose?
3) ADE”s?
4) precautions?
- Selective 5HT1F agonist for acute migraine +/- aura in adults
- 200 mg PO everyday
- DIzzy , fatigue, sedation, burning/prickling skin sensation –> Dont drive or ooperate machinery for 8 hrs after taking med!!!!
- Decr in HR, incr in BP –> Doesnt constrict blood vessels and may role a role for pt’s with cardiovasc CI to triptans
Ubrogepant (Ubrelvy)
1) Bc it doesnt constrict blood vessels, it has a role for which set of pt’s?
2) MOA?
3) For what kind of migraines ?
4) Dose?
5) ADR’s? (3)
6) CI’s?
- Cardiovasc CI patients to triptans
- Oral (CGRP) antag
- Acute migraine +/- aura in adults
- 200 mg PO everyday
-if CrCL 15-29, 50 mg PO daily –> if CRCL < 15 AVOID !!!!
- If severe hepatic disease, dose adjust to 50 mg - Nausea /Somnolence, dry mouth (Dose dependent )
- Strong CYP 3a4 inhibs (avoid or reduce dose)
Rimegepant (NURTEC ODT)
1) No BV constriction –> Can use in Cardio Pts
2) First fast acting ODT ___
3) can be used for ?
4) dosing ?
5) AE’s?
6) With concomitant use of moderate CYP 3A4 inhibs what should u do?
Zavegepant (Zavzpret)
1. what kind of drug
2. what kind of migraines
3. dose?
4. Ae’s?
5. Safe for pt’s with ?
6. avoid use of ___ or administer 1 hr AFTER this drug
7. AVoid use in CrCL < ___ and in severe hepatic impairment
- CGRP receptor antag
- acute migraine +/- aura in adults (+ PREVENTION!) –> sustained benefit for 2 days
- 75 mg ODT (max 1 pill per day) avoid if CrCL<15
- Nausea
- avoid 2nd dose of nurtec within 48 hrs
- nasal spray CGRP receptor antag
- acute migraines +/- aura, ideal for those w/nausea or who dont wanna swallow tabs
- 10 mg single spray in 1 nostril PRN (Max 10 mg/day)
- Dysgeusia and ageusia, N/V, Nasal discomfy
- HX of MI/CVA
- intranasal decongestants
- 30 mL/min
DHE (Dihydroergotamine)
1. what place in therapy ?
2. MOA?
3. Most effective given at ????
4. Migranal Nasal SPray has better effectiveness than INJECTIONS –> Dosing?
- DHE 45 (IV, IM or SQ)
- Dose ?
-Effective in tx of?
- SECOND LINE
- Non select 5HT1receptor AGONIST –> constricts intracranial vessels
- ONSET of migraine
- 1 spray (0.5mg) into each nostril at onset of aura , can repeat 1 spray each nostril in 15 min (max 3mg/day)
- 1 mg at onset, repeat every 1 hr prn (max 3 mg/day for IM/SQ and 2mg/day for IV)
- Acute and INTRACTABLE migraine
ADR’s for DHE? :
N/V/D pre treat with ?
A
Transient
T
Incr ___
Peripheral
T!!!, L !!
G
D
Rebound ___
Nasal irritation
F, D, T
BBW FOR DHE?
INTERACTIONS?
Preg category X (FYI)
Anti emetic
angina
transient bradycardia
tachycardia
BP
peripheral numbness
TINGLING, LEG CRAMPS!
gangrene , dizzy, rebound HA, Fatigue, dry mouth, taste perversion
BBW : Serious/life threatening peripheral ischemia with potent CYP 3A4 inhibs
(CI with PI’s and macrolides)
BETA BLOCKERS, Triptans
Medication Overuse Headache (Rebound HA) : Adjunctive tx
1. Pt’s should limit medication to average of how many times a week?
- Migraines with med overuse causing rebound can be accompanied by ?
- Adjunctive tx : Pretx w/antiemetic –> Which 2 drugs are u gonna consider?
- 2 days/week
- N/V
- Metoclopramide (reglan) 10-20 mg PO, 15-30 mins before abortive medications
-Compazine 10 mg PO or 25mg rectal suppos then q4h prn
Chronic Migraines
1. Headaches how often ?
- When should we consider preventative migraine tx?
- Define overuse
- HA>=15 days/month for >3 months AND >= 8 days of migraine sx’s
- based on number of HA days/months or degree of disability
-CI to , failure or overuse of acute tx
-ADE with acute tx option , and patient preference - > 10 days/month for DHE, triptans, opioids, combo analgesics
> =15 days/month for non opioid analgesics, nsaids, and APAP
Prophylaxis Reccs :
1) First line options? (7)
2) Second line ? (6)
- Divalproex, frovatriptan
Metoprolol, propanolol , timolol
Topiramate, ANti CGRP MABS and CGRP antags —> CGRP therapies now first line for prevention - Amitriptyline, atenolol , nadolol
naratriptan, venlafaxine, zolmitriptan
Beta Blockers :
1) Prevent ___ or ___
2. does not reduce ___
3. Propanolol , Metoprolol, Timolol dose
4. AE’s ?
Antiepileptics :
Delayed Release Divalproex
1. FDA approved for
2. for which group of pt’s?
3. Preg categ X , and avoid use in ?
Topiramate
1. as effective as ?
2. preg categ D (dont use!)
3. Also dont use in the following
- Vasodilation , serotonergic effects
- aura
- 40 mg PO BID-TID
50mg PO BID
20-30mg PO daily - Bradycardia, fatigue, hypotension, depression, decr exercise tolerance, nightmares, insomnia, and impotence
- Migraine prevention!
- < 65 yrs
- Liver disease
- amitriptyline and propanolol
- Glaucoma, kidney stones, liver disease
Antidepressants : Amitriptyline
1. Dose?
2. MOA
3. ADR’s
4. CI?
ANtidepress : Venlafaxine
1. Dose ?
2. MOA?
3. When discontinuing, taper ____
- 10-25 mg QHS
- block 5HT re-uptake at central sites
- sedation, ortho hypo, anticholinergic in old peeps , weight gain, dry mouth
- Narrow angle glaucoma, cardiac arrhythmias, bipolar, uncontrolled epilepsy
- 37.5 mg PO daily x 3 days –> 75 mg daily x 3days –> 150 mg daily
- selective Serotonin/NE reuptake inhibitor
- taper slowly to avoid withdrawal sx
Cluster HA :
Males > Females
1. Sx’s?
2. No __ and NO ___
3. What can precipitate?
4. usually self limiting and lasts ?
5. Tends to be “clustered” around same time each year and can last ??
- Usually unilateral. Deep, sharp pain usually centered around same eye. Lacrimation, rhinorrhea, eyelid drooping
- aura. NV
- Smoking, alc, and naps
- 15mins-2 hrs
- days - weeks (can occur daily)
Cluster HA -Abortive TX
1) what are the 2 regimens u can use?
2) What can you use for prophylaxis + tx? (Injection )
3) What are other prophylaxis regimens for cluster headaches? (3)
- O2 inhalation 6-12 L/min x 10-15 mins
-rapid acting triptans (Sumatriptan SQ 6 mg at onset, zolmatriptan NS 5-10 mg at onset) - Galcanezumab (EMGALITY) : 300 mg SQ at cluster onset and then monthly until end of cluster period
- Verapamil (preferred) initially 80 mg PO TID , Prednisone 40mg QDx2days then taper,
Lithium 300 mg BID(second line)
Tension HA : Most Common Type of HA
- Presentation
-___ HA that worsens thruout day
-location ?
-can be associated with ?
-can occur when ?
-duration is more variable than ___
-What can precipitate?
-What can improve? - ABortive therapy options? (3)
- Prophylaxis?
- DULL
- variable, bandlike, starts at top or back of head then generalize
- depression or anxiety
-daily
-cluster HA
-Stress and fatigue
-relaxation , alcohol - Non opioid analgesics (APAP, nsaids, ASA, combo product with doxylamine)
-Butalbital and codeine combos (should be avoided)
-Sedatives/anxiolytics (Butalbital and diazepam) - Amitriptyline 30-75 mg /day –> should taper down /discontinue after 3-4 months if effective
-Mirtazapine 30mg
-Venlafaxine 150 mg/day