Head trauma Flashcards
TBI classifications?
Mild TBI - GCS 14-15
Mod TBI - GCS 9-13
Sev TBI - GCS 3-8
Mild TBI AKA as?
Concussion
Most severe TBI deaths occur when?
w/in 48hrs
Cerebral blood flow is dependent on?
Autoregulation CPP - Cerebral perfusion pressure MAP - Mean arterial pressure ICP - Intracranial pressure V-Con from systemic factors (HTN, Alkalosis, etc)
W/ a TBI what is often impaired concerning cerebral blood flow homeostasis?
Autoregulation
Lower limit of autoregulation is?
<60mmHg CPP
Traumatic HOTN can lead to what in low flow regions of the brain?
Ischemia
TBI often require what?
Aggresive fluid resusicitation to PVT HOTN
What should Mean arterial pressure be maintained at concerning a TBI?
> =80 mmHg
Low BP + ^ICP will result in?
Low CPP and brain injury
Primary brain injuries include?
Contusions Hematomas DIffuse axonal injury Direct cellular damage Loss of BBB Disrupted Neurochemical homeostasis Loss of electrochemical fx
Contusions are?
Bruises to the brain paraenchyma
Hematomas types are?
Subdural Epidural Intraparenchymal Intraventricular Subarachnoid
Secondary brain injuries?
Serious of (sub)cellular events
- Neurotoxic cascade of massive neurotransmitter release
- Ion shifts > activate cytoplasmis/nuclear enzymes > cell Apoptosis
- Extensive neuronal loss occurring for longer than a yr
Secondary insults are?
Conditions accelerating neurotoxic damage
-HOTN, Hypoxemia, Hyperglycemia
Brain edema is a result of what two processes?
LRG ionic shifts > Cellular swelling
Damage/Breakdown of BBB > Extracellular edema
Brain edema evolves into?
Increased ICP >
Direct compression tissue damage >
Vascular compression >
Ischemia, herniation, brain death