HEAD & NECK CANCER Flashcards

1
Q

What does head and neck cancer include?

A

Oral cavity cancers
Cancers of the pharynx (including the oropharynx, hypopharynx and nasopharynx)
Cancers of the larynx

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2
Q

NICE suspected cancer pathway referral criteria for ?laryngeal cancer?

A

people aged 45 years and over with:
Persistent unexplained hoarseness, or
An unexplained lump in the neck.

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3
Q

NICE suspected cancer pathway referral criteria for ?oral cancer?

A

people with either:
Unexplained ulceration in the oral cavity lasting for more than 3 weeks, or
A persistent and unexplained lump in the neck .

for assessment for possible oral cancer by a dentist in people who have either:
A lump on the lip or in the oral cavity, or
A red or red and white patch in the oral cavity consistent with erythroplakia or erythroleukoplakia.

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4
Q

NICE suspected cancer pathway referral criteria for ?thyroid cancer?

A

people with an unexplained thyroid lump.

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5
Q

What is the field of cancerisation effect?

A

a biological process in which large areas of cells at a tissue surface or within an organ are affected by carcinogenic alterations.

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6
Q

Why % of pt with head and neck cancers have a second primary malignancy? Why?

A

1 in 10
Due to the field of cancerisation effect

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7
Q

Whats the most common site for head & neck malignancy?

A

Oral

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8
Q

Most common type of head and neck cancer?

A

Squamous cell carcinoma

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9
Q

Presentation of laryngeal cancer?

A

Hoarseness
Throat pain
Dysphagia

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10
Q

Method of diagnosis for laryngeal cancer?

A

laryngoscopy and biopsy

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11
Q

How does oral cancer present?

A

persistent ulceration, a mass, or abnormal bleeding.
It can present as advanced disease with regional lymphadenopathy.

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12
Q

How do we diagnose oral cancer?

A

Some recognised visually but definitive diagnosis requires a biopsy

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13
Q

How does thyroid cancer present?

A

Nodule within the thyroid gland or a diffuse thyroid swelling
May also present with regional lymphadenopathy

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14
Q

Whats the most common type of thyroid cancer?

A

Papillary

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15
Q

Who is papillary thyroid cancer most common in?

A

Young females

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16
Q

How do we diagnose thyroid cancer?

A

Definitively by biopsy

17
Q

Risk factors for head and neck cancers?

A

Smoking
Chewing tobacco
Chewing betel nut
Alcohol
HPV
EBV

18
Q

Which thyroid cancer has the best prognosis?

A

Papillary thyroid cancer

19
Q

Whats the most common salivary gland for a tumour?

A

Parotid gland

20
Q

What are the most common benign tumours of salivary glands?

A

Pleomorphic adenomas

21
Q

Symptoms of maligannt salivary gland tumours?

A

Rapidly growing painful mass with overlying skin ulceration
Facial palsy

22
Q

How does a benign pleomorphic adenoma present?

A

Painless, slowly enlarging lump in the retromandibular region

23
Q

Why must benign pleomorphic adenomas be surgically removed?

A

As they have a 10% malignant transformation potential

24
Q

Whats the most common salivary gland cancer?

A

Mucoepidermoid tumour - most commonly in parotid gland

25
Big risk factor for carcinoma of the lip?
Sun exposure
26
Where is carcinoma of the nasopharynx high in incidence?
North and South Asia. - rare here
27
Biggest risk factor for carcinoma of the nasopharynx?
EBV
28
Presentation of carcinoma of the nasopharynx?
Cervical lymphadenopathy Ear pain, secretory otitis media, hearing loss, CN palsies Epistaxis, discharge from nose, changes in smell, nasal obstruction
29
What are carcinomas of the oropharynx most associated with?
Smoking Alcohol HPV 16 and 18
30
Which region of the larynx is most common for carcinoma of the larynx?
Glottis region
31
Premalignant lesions of oral cancers?
Leukoplakia Erythroplakia
32
What is leukoplakia?
A pre malignant condition which presents as white, hard spots on the mucous membranes of the mouth
33
Who is leukoplakia common in?
Smokers
34
How do we diagnose leukoplakia?
It’s a diagnosis of exclusion Biopsy
35
Differential diagnosis of leukoplakia?
Candidiasis - esp if can be rubbed off Lichen planus - esp if can be rubbed off Squamous cell carcinoma
36
What is the rate of malignant transformation of leukoplakia to SCC?
1%
37
What is erythroplakia?
A red lesion in the mucous membranes A pre-malignant lesion of SCC
38
What can Fanconi anaemia be a pre malignant condition of?
Oral SCC
39
What can Plummer-Vinson syndrome be a pre malignant condition of?
Cricopharyngeal carcinoma