Head and Neck cancers Flashcards
Erythroplakia
Pre-malignant condition with red patch or plaque that cannot be rubbed off and cannot be characterized clinically as another disease
Red color due to vascular submucosal tissue shining through under-keratinized mucosa
Erythroplakia is how many times more likely malignant than Leukoplakia
17
Treatment/Intervention for Erythroplakia
Excision biopsy
Leukoplakia
white mouth lesions
can be cancerous or pre cancerous
Head and neck cancers are typically what type of cancer
Squamous cell carcinoma
Categories of Head and Neck Cancer
• paranasal sinuses, oral cavity, nasopharynx, oropharynx, and larynx
(Oral, pharynx, and larynx cancers
At what stage are head and neck cancers usually diagnosed
advanced - further debilitating with treatment
RISK FACTORS for head and neck cancers
- 85% caused by tobacco
- Alcohol use
- Advanced age (50 or greater); Males
- Younger than 50: associated with HPV
- Poor oral hygiene
- Sun exposure
- Occupational exposure: asbestos, cement dust
CLINICAL MANIFESTATIONS of head and neck cancer
- Vary with location of tumor
- Non-specific: sore throat; sore mouth (does not get better); burning when drinking hot liquids or orange juice
- Voice changes; lump in throat; enlarged cervical lymph nodes
- Hoarseness more than 2 weeks
- Leukoplakia (white patch) or erythroplakia (fiery red patch) on mouth or tongue
- Ulcer that do not heal: lip or tongue with thickening
- Change in fit of dentures
LATE:
• Coughing up blood; Increased salivation
• Slurred speech
• Dysphagia; difficulty moving tongue or jaw
• Swelling of neck; toothache; earache
• Difficulty breathing; partially or fully airway obstruction
DIAGNOSTIC STUDIES FOR HEAD AND NECK CANCER
- Early detection – key to survival
- History and physical examination
- Pharyngoscopy or laryngoscopy
- Endoscopy
- Chest x-ray
- Barium swallow
- Biopsy
- TNM staging
- Oral exfoliative cytology
- Toluidine blue test
- CT; MRI; position emission tomography (PET)
TREATMENT OF HEAD AND NECK CANCER
- Surgery
- Radiation therapy
- Chemotherapy
- Target therapy
- Combination of modalities
- Considerations: location of tumor, TNM stage, age and overall health, urgency, residual from treatment
- Patient’s choice
Two types of oral cancer
• Oral cavity cancer (develops in the mouth)
Oropharyngeal cancer (develops in throat just beyond the mouth)
TREATMENT OF ORAL CANCER
- Partial mandibulectomy
- Hemi glossectomy; glossectomy
- Resections of buccal mucosa and of the floor of mouth;
- Radical neck dissection: removal of primary lesion, lymph nodes, sternocleidomastoid muscle, internal jugular vein, mandible, submaxillary gland, spinal accessory nerve: may involve removal of mandible, submaxillary gland, patient of thyroid and parathyroid)
- Radiation
- Chemotherapy
LARYNX CANCER
• Most common upper respiratory malignancy
• Subglottic: involves the epiglottis and false cords; likely to produce no symptoms until advanced
Glottic – effects true vocal cords; occurs most frequently; produces early symptoms
TREATMENT OF LARYNX CANCER
Radation
chemotherapy/targeted therapy
Surgery
- partial laryngectomy
- total laryngectomy
- Radial neck dissection