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HEMATOLOGY 2 > HARR_2.1 Coagulation and Fibrinolytic Systems/Reagents and Methods > Flashcards

HARR_2.1 Coagulation and Fibrinolytic Systems/Reagents and Methods Flashcards

1
Q

Which of the following initiates in vivo coagulation by activation of factor VII?

A. Protein C
B. Tissue factor (TF)
C. Plasmin activator
D. Thrombomodulin (TM)

A

Tissue factor (TF)

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2
Q

Which of the following clotting factors plays a role in clot formation in vitro, but not in vivo?
A. Factor VIIa
B. Factor IIa
C. Factor XIIa
D. Factor Xa

A

Factor XIIa

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3
Q

The anticoagulant of choice for most routine coagulation studies is:

A. Sodium oxalate
B. Sodium citrate
C. Heparin
D. Ethylenediaminetetraacetic acid (EDTA)

A

Sodium citrate

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4
Q

Which anticoagulant:blood ratio is correct for coagulation procedures?

A. 1:4
B. 1:5
C. 1:9
D. 1:10

A

1:9

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5
Q

Which results would be expected for PT and APTT in a patient with polycythemia?
A. Both prolonged
B. Both shortened
C. Normal PT, prolonged APTT
D. Both normal

A

Both prolonged

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6
Q

Which reagents are used in the PT test?
A. Thromboplastin and sodium chloride
B. Thromboplastin and potassium chloride
C. Thromboplastin and calcium
D. Actin and calcium chloride

A

Thromboplastin and calcium

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7
Q

Which test would be abnormal in a patient with factor X deficiency?
A. PT only
B. APTT only
C. PT and APTT
D. Thrombin time (TT)

A

PT and APTT

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8
Q

Which clotting factor is not measured by the PT and APTT tests?
A. Factor VIII
B. Factor IX
C. Factor V
D. Factor XIII

A

Factor XIII

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9
Q

A modification of which procedure can be used to measure fibrinogen?
A. PT
B. APTT
C. TT
D. Fibrin degradation products

A

TT

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10
Q

Which of the following characterizes vitamin K?
A. It is required for biological activity of fibrinolysis
B. Its activity is enhanced by heparin therapy
C. It is required for carboxylation of glutamate residues of some coagulation factors
D. It is made by endothelial cells

A

It is required for carboxylation of glutamate residues of some coagulation factors

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11
Q

Which fragments of fibrin clot degradation are measured by the D-dimer test?
A. Fragments X and Y
B. Fibrinopeptide A and B
C. Fragments D and E
D. The D-D domains

A

The D-D domains

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12
Q

Which of the following clotting factors are measured by the APTT test?
A. Factors II, VII, IX, X
B. Factors VII, X, V, II, I
C. Factors XII, XI, IX, VIII, X, V, II, I
D. Factors XII, VII, X, V, II, I

A

Factors XII, XI, IX, VIII, X, V, II, I

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13
Q

Which coagulation test(s) would be abnormal in a patient with vitamin K deficiency?
A. PT only
B. PT and APTT
C. Fibrinogen level
D. TT

A

PT and APTT

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14
Q

Which of the following is correct regarding the international normalized ratio (INR)?
A. It uses the international sensitivity ratio (ISR)
B. It standardizes PT results
C. It standardizes APTT results
D. It is used to monitor heparin therapy

A

It standardizes PT results

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15
Q

Which of the following is referred to as an endogenous activator of plasminogen?
A. Streptokinase
B. Transamidase
C. Tissue plasminogen activator (tPA)
D. tPA inhibitor

A

Tissue plasminogen activator (tPA)

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16
Q

Which protein is the primary inhibitor of the fibrinolytic system?

A. Protein C
B. Protein S
C. α2-Antiplasmin
D. α2-Macroglobulin

A

α2-Antiplasmin

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17
Q

Which of the following statements is correct regarding the D-dimer test?
A. Levels are decreased in DIC
B. Test detects polypeptides A and B
C. Test detects fragments D and E
D. Test has a negative predictive value

A

Test has a negative predictive value

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18
Q

A protein that plays a role in both coagulation and PLT aggregation is:
A. Factor I
B. Factor VIII
C. Factor IX
D. Factor XI

A

Factor I

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19
Q

A standard 4.5-mL blue-top tube filled with 3.0 mL of blood was submitted to the
laboratory for PT and APTT tests. The sample is from a patient undergoing surgery the
following morning for a tonsillectomy. Which of the following is the necessary course of
action by the medical laboratory scientist?
A. Run both tests in duplicate and report the average result
B. Reject the sample and request a new sample
C. Report the PT result
D. Report the APTT result

A

Reject the sample and request a new sample

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20
Q

Which statement is correct regarding sample storage for the PT test?
A. Stable for 24 hours if the sample is capped
B. Stable for 24 hours if the sample is refrigerated at 4°C
C. Stable for 4 hours if the sample is stored at 4°C
D. Should be run within 8 hours

A

Stable for 24 hours if the sample is capped

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21
Q

In primary fibrinolysis, the fibrinolytic activity results in response to:
A. Increased fibrin formation
B. Spontaneous activation of fibrinolysis
C. Increased fibrin monomers
D. DIC

A

Spontaneous activation of fibrinolysis

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22
Q

Plasminogen deficiency is associated with:
A. Bleeding
B. Thrombosis
C. Increased fibrinolysis
D. Increased coagulation

A

Thrombosis

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23
Q

Which of the following clotting factors are activated by thrombin that is generated by
tissue pathway (TF-VIIa)?
A. Factors XII, XI
B. Factors XII, I
C. Factors I, II
D. Factors V, VIII

A

Factors V, VIII

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24
Q

Which substrate is used in a chromogenic factor assay?
A. p-nitroaniline (pNa)
B. Chlorophenol red
C. Prussian blue
D. Ferricyanide

A

p-nitroaniline (pNa)

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25
Q

Which substrate is used in a chromogenic factor assay?
A. p-nitroaniline (pNa)
B. Chlorophenol red
C. Prussian blue
D. Ferricyanide

A

p-nitroaniline (pNa)

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26
Q

Which of the following antibodies is used in the D-dimer assay?
A. Polyclonal antibody directed against X and Y fragments
B. Polyclonal antibody directed against D-dimer
C. Monoclonal antibody against D and E fragments
D. Monoclonal antibody against D-dimer

A

Monoclonal antibody against D-dimer

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27
Q

Thrombotic thrombocytopenic purpura (TTP) is characterized by:
A. Prolonged PT
B. Increased PLT aggregation
C. Thrombocytosis
D. Prolonged APTT

A

Increased PLT aggregation

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28
Q

Thrombocytopenia may be associated with:
A. Splenectomy
B. Hypersplenism
C. Acute blood loss
D. Increased proliferation of pluripotent stem cells

A

Hypersplenism

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29
Q

Aspirin prevents PLT aggregation by inhibiting the action of which enzyme?
A. Phospholipase
B. Cyclo-oxygenase
C. Thromboxane A2 (TXA2) synthetase
D. Prostacyclin synthetase

A

Cyclo-oxygenase

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30
Q

Normal PLT adhesion depends on:
A. Fibrinogen
B. Glycoprotein Ib
C. Glycoprotein IIb–IIIa complex
D. Calcium

A

Glycoprotein Ib

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31
Q

Which of the following test results is normal in a patient with classic von Willebrand
disease?
A. PLT aggregation
B. APTT
C. PLT count
D. Factor VIII:C and von Willebrand factor (VWF) levels

A

PLT count

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32
Q

Bernard–Soulier syndrome is associated with:
A. Decreased factor IX
B. Decreased factor VIII
C. Thrombocytopenia and giant PLTs
D. Abnormal PLT function test results

A

Thrombocytopenia and giant PLTs

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33
Q

When performing PLT aggregation studies, which set of PLT aggregation results would
most likely be associated with Bernard–Soulier syndrome?
A. Normal PLT aggregation to collagen, adenosine diphosphate (ADP), and ristocetin

B. Normal PLT aggregation to collagen, ADP, and epinephrine (EPI); decreased aggregation to ristocetin

C. Normal PLT aggregation to EPI and ristocetin; decreased aggregation to collagen and ADP

D. Normal PLT aggregation to EPI, ristocetin, and collagen; decreased aggregation to ADP

A

Normal PLT aggregation to collagen, ADP, and epinephrine (EPI); decreased aggregation to ristocetin

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34
Q

Which set of PLT responses would be most likely associated with Glanzmann thrombasthenia?
A. Normal PLT aggregation to ADP and ristocetin; decreased aggregation to collagen

B. Normal PLT aggregation to collagen; decreased aggregation to ADP and ristocetin

C. Normal PLT aggregation to ristocetin; decreased aggregation to collagen, ADP, and EPI

D. Normal PLT aggregation to ADP; decreased aggregation to collagen and ristocetin

A

Normal PLT aggregation to ristocetin; decreased aggregation to collagen, ADP, and EPI

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35
Q

Which of the following is a characteristic of acute immune thrombocytopenic purpura?
A. Spontaneous remission within a few weeks
B. Predominantly seen in adults
C. Nonimmune PLT destruction
D. Insidious onsent

A

Spontaneous remission within a few weeks

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36
Q

TTP differs from DIC in that:
A. APTT is normal in TTP but prolonged in DIC
B. Schistocytes are not present in TTP but are present in DIC
C. PLT count is decreased in TTP but normal in DIC
D. PT is prolonged in TTP but decreased in DIC

A

APTT is normal in TTP but prolonged in DIC

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37
Q

Several hours after birth, a baby boy develops petechiae and purpura and hemorrhagic diathesis. The PLT count is 18 × 109/L. What is the most likely explanation for the low
PLT count?
A. Drug-induced thrombocytopenia
B. Secondary thrombocytopenia
C. Neonatal alloimmune thrombocytopenia
D. Neonatal DIC

A

Neonatal alloimmune thrombocytopenia

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38
Q
  1. Which of the following is associated with post-transfusion purpura (PTP)?
    A. Nonimmune thrombocytopenia/alloantibodies
    B. Immune-mediated thrombocytopenia/alloantibodies
    C. Immune-mediated thrombocytopenia/autoantibodies
    D. Nonimmune-mediated thrombocytopenia/autoantibodies
A

Immune-mediated thrombocytopenia/alloantibodies

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39
Q

Hemolytic uremic syndrome (HUS) is associated with:
A. Fever, thrombocytosis, anemia, and renal failure
B. Fever, granulocytosis, and thrombocytosis
C. Escherichia coli 0157:H7
D. Leukocytosis and thrombocytosis

A

Escherichia coli 0157:H7

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40
Q

Storage pool deficiencies are defects of:
A. PLT adhesion
B. PLT aggregation
C. PLT granules
D. PLT production

A

PLT granules

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41
Q

Lumi-aggregation measures:
A. PLT aggregation only
B. PLT aggregation and adenosine triphosphate (ATP) release
C. PLT adhesion
D. PLT glycoprotein Ib

A

PLT aggregation and adenosine triphosphate (ATP) release

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42
Q

Neurological findings may be commonly associated with which of the following disorders?
A. HUS
B. TTP
C. ITP
D. PTP

A

TTP

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43
Q

Which of the following is correct regarding acquired TTP?
A. Autoimmune disease
B. Decreased VWF
C. Decreased PLT aggregation
D. Decreased PLT adhes

A

Autoimmune disease

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44
Q

Hereditary hemorrhagic telangiectasia is a disorder of:
A. PLTs
B. Clotting proteins
C. Fibrinolysis
D. Connective tissue

A

Connective tissue

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45
Q

Which of the following prevents PLT aggregation?
A. TXA2
B. Thromboxane B2
C. Prostacyclin
D. Antithrombin (AT)

A

Prostacyclin

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46
Q

Which defect characterizes Gray syndrome?
A. PLT adhesion defect
B. Dense granule defect
C. Alpha granule defect
D. Coagulation defect

A

Alpha granule defect

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47
Q

The P2Y12 ADP receptor agonist assay may be used to monitor PLT aggregation
inhibition to which of the following drugs?
A. Warfarin
B. Heparin
C. Low-molecular-weight heparin (LMWH)
D. Clopidogrel (Plavix)

A

Clopidogrel (Plavix)

48
Q

Which of the following instruments can be used to evaluate PLT function?
A. PLT aggregometer
B. VerifyNow
C. PFA-100
D. All of the above

A

All of the above

49
Q

Which of the following PLT aggregating agents demonstrates a monophasic aggregation curve when used in the optimal concentration?
A. Thrombin
B. Collagen
C. ADP
D. EPI

50
Q

The APTT is sensitive to a deficiency of which clotting factor?
A. Factor VII
B. Factor X
C. PF3
D. Calcium

51
Q

Which test result would be normal in a patient with dysfibrinogenemia?
A. TT
B. APTT
C. PT
D. Immunologic fibrinogen level

A

Immunologic fibrinogen level

52
Q

A patient with a prolonged PT is given intravenous vitamin K. PT is corrected to normal after 24 hours. Which clinical condition most likely caused these results?
A. Necrotic liver disease
B. Factor X deficiency
C. Fibrinogen deficiency
D. Obstructive jaundice

A

Obstructive jaundice

53
Q

Which factor deficiency is associated with prolonged PT and APTT?
A. Factor X
B. Factor VIII
C. Factor IX
D. Factor XI

54
Q

Prolonged APTT is corrected with factor VIII–deficient plasma but not with factor IX–deficient plasma. Which factor is deficient?
A. Factor V
B. Factor VIII
C. Factor IX
D. Factor X

55
Q

Which of the following is a characteristic of classic hemophilia A?
A. Abnormal PLT aggregation
B. Autosomal recessive inheritance
C. Mild to severe bleeding episodes
D. Prolonged PT

A

Mild to severe bleeding episodes

56
Q

Refer to the following results:
PT = prolonged
APTT = prolonged
PLT count = decreased
Which disorder may be indicated?

A. Factor VIII deficiency
B. von Willebrand disease
C. DIC
D. Factor IX deficiency

57
Q

Which of the following is a predisposing condition for the development of DIC?

A. Adenocarcinoma
B. Idiopathic thrombocytopenic purpura (ITP)
C. Post transfusion purpura (PTP)
D. Heparin-induced thrombocytopenia (HIT)

A

Adenocarcinoma

58
Q

Factor XII deficiency is associated with:
A. Bleeding episodes
B. Epistaxis
C. Decreased risk of thrombosis
D. Increased risk of thrombosis

A

Increased risk of thrombosis

59
Q

The following results were obtained on a patient: normal PLT count and function, normal PT, and prolonged APTT. Which of the following disorders is most consistent
with these results?
A. Hemophilia A
B. Bernard–Soulier syndrome
C. von Willebrand disease
D. Glanzmann thrombasthenia

A

Hemophilia A

60
Q

The following laboratory results were obtained from a 40-year-old woman: PT = 20 sec; APTT = 50 sec; TT = 18 sec. What is the most probable diagnosis?

A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor X deficiency
D. Hypofibrinogenemia

A

Hypofibrinogenemia

61
Q

When performing a factor VIII activity assay, a patient’s plasma is mixed with:
A. Normal patient plasma
B. Factor VIII–deficient plasma
C. Plasma with a high concentration of factor VIII
D. Normal control plasma

A

Factor VIII–deficient plasma

62
Q

The most suitable product for treatment of factor VIII deficiency is:
A. Fresh frozen plasma (FFP)
B. Factor VIII concentrate
C. Prothrombin complex concentrate
D. Factor V Leiden

A

Factor VIII concentrate

63
Q

Which of the following is associated with an abnormal PLT aggregation test result?

A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Afibrinogenemia

A

Afibrinogenemia

64
Q

Refer to the following results:
PT = normal
APTT = prolonged
PLT count = normal
PLT aggregation to ristocetin = abnormal
Which of the following disorders may be indicated?

A. Factor VIII deficiency
B. DIC
C. von Willebrand disease
D. Factor IX deficiency

A

von Willebrand disease

65
Q

Which results are associated with hemophilia A?
A. Prolonged APTT, normal PT
B. Prolonged PT and APTT
C. Prolonged PT, normal APTT
D. Normal PT and APTT

A

Prolonged APTT, normal PT

66
Q

Fibrin monomers are increased in which of the following conditions?
A. Primary fibrinolysis
B. DIC
C. Factor VIII deficiency
D. Fibrinogen deficiency

67
Q

Which of the following is associated with multiple factor deficiencies?

A. An inherited disorder of coagulation
B. Severe liver disease
C. Dysfibrinogenemia
D. Lupus anticoagulant

A

Severe liver disease

68
Q

Normal PT and APTT results in a patient with poor wound healing may be associated with:
A. Factor VII deficiency
B. Factor VIII deficiency
C. Factor XII deficiency
D. Factor XIII deficiency

A

Factor XIII deficiency

69
Q

Fletcher factor (prekallikrein) deficiency may be associated with:
A. Bleeding
B. Thrombosis
C. Thrombocytopenia
D. Thrombocytosis

A

Thrombosis

70
Q

One of the complications associated with a severe hemophilia A is:
A. Hemarthrosis
B. Mucous membrane bleeding
C. Mild bleeding during surgery
D. Immune-mediated thrombocytopenia

A

Hemarthrosis

71
Q

The most common subtype of classic von Willebrand disease is:
A. Type 1
B. Type 2A
C. Type 2B
D. Type 3

72
Q

Prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient?
A. Factor VIII
B. Factor V
C. Factor XI
D. Factor IX

73
Q

Which characteristic describes antithrombin (AT)?
A. It is synthesized in megakaryocytes
B. It is activated by protein C
C. It is a cofactor of heparin
D. It is a pathological inhibitor of coagulation

A

It is a cofactor of heparin

74
Q

Which laboratory test is affected by heparin therapy?
A. Thrombin time
B. Fibrinogen assay
C. Protein C assay
D. Protein S assay

A

Thrombin time

75
Q

Abnormal APTT caused by a pathological circulating anticoagulant is:
A. Corrected with factor VIII–deficient plasma
B. Corrected with factor IX–deficient plasma
C. Corrected with normal plasma
D. Not corrected with normal plasma

A

Not corrected with normal plasma

76
Q

The lupus anticoagulant affects which of the following tests?
A. Factor VIII assay
B. Factor IX assay
C. VWF assay
D. Phospholipid-dependent assays

A

Phospholipid-dependent assays

77
Q

Which statement about warfarin (Coumadin) is accurate?
A. It is a vitamin B antagonist
B. It is not recommended for pregnant and lactating women
C. It needs AT as a cofactor
D. APTT test is used to monitor its dosage

A

It is not recommended for pregnant and lactating women

78
Q

Which statement regarding protein C is correct?
A. It is a vitamin K–independent zymogen
B. It is activated by fibrinogen
C. It activates cofactors V and VIII
D. Its activity is enhanced by protein S

A

Its activity is enhanced by protein S

79
Q

Which of the following is an appropriate screening test for the diagnosis of lupus anticoagulant?
A. Thrombin time
B. Diluted Russell viper venom test (DRVVT)
C. D-dimer test
D. Fibrinogen assay

A

Diluted Russell viper venom test (DRVVT)

80
Q

Which of the following is most commonly associated with activated protein C resistance
(APCR)?
A. Bleeding
B. Thrombosis
C. Epistaxis
D. Menorrhagia

A

Thrombosis

81
Q

A 50-year-old man has been on heparin for the past 7 days. Which combination of tests
is expected to be abnormal?
A. PT and APTT only
B. APTT, TT only
C. APTT, TT, fibrinogen assay
D. PT, APTT, TT

A

PT, APTT, TT

82
Q

Which of the following drugs inhibits ADP-mediated PLT aggregation?
A. Heparin
B. Warfarin
C. Aspirin
D. Prasugrel

83
Q

Thrombin–TM complex is necessary for activation of:
A. Protein C
B. AT
C. Protein S
D. Factors V and VIII

84
Q

Which test is used to monitor heparin therapy?
A. INR
B. Chromogenic anti–factor Xa assay
C. TT
D. PT

A

Chromogenic anti–factor Xa assay

85
Q

Which test is commonly used to monitor warfarin therapy?
A. INR
B. APTT
C. TT
D. Ecarin time

86
Q

Which clotting factors (cofactors) are inhibited by protein S?
A. Factors V and X
B. Factors Va and VIIIa
C. Factors VIII and IX
D. Factors VIII and X

A

Factors Va and VIIIa

87
Q

Which drug promotes fibrinolysis?
A. Warfarin
B. Heparin
C. Urokinase
D. Aspirin

88
Q

Diagnosis of lupus anticoagulant is confirmed by which of the following criteria?
A. Decreased APTT
B. Correction of APPT by mixing studies
C. Neutralization of the antibody by high concentration of phospholipids
D. Confirmation that abnormal coagulation tests are related to factor deficiencies

A

Neutralization of the antibody by high concentration of phospholipids

89
Q

Which of the following abnormalities is consistent with the presence of lupus
anticoagulant?
A. Decreased APTT/bleeding complications
B. Prolonged APTT/thrombosis
C. Prolonged APTT/thrombocytosis
D. Thrombocytosis/thrombosis

A

Prolonged APTT/thrombosis

90
Q

Which of the following is a characteristic of LMWH?
A. Generally requires monitoring
B. Specifically acts on factor Va
C. Has a longer half-life compared with unfractionated heparin (UFH)
D. Can be used as a fibrinolytic agent

A

Has a longer half-life compared with unfractionated heparin (UFH)

91
Q

Which of the following tests is most likely to be abnormal in patients taking aspirin?
A. PLT morphology
B. PLT count
C. PLT aggregation
D. PT

A

PLT aggregation

92
Q

Which of the following is associated with AT deficiency?
A. Thrombocytosis
B. Thrombosis
C. Thrombocytopenia
D. Bleeding

A

Thrombosis

93
Q

Which of the following may be associated with thrombotic events?
A. Decreased protein C
B. Increased fibrinolysis
C. Afibrinogenemia
D. Idiopathic thrombocytopenic purpura

A

Decreased protein C

94
Q

Aspirin resistance may be associated with:
A. Bleeding
B. Factor VIII deficiency
C. Thrombosis
D. Thrombocytosis

A

Thrombosis

95
Q

Prolonged TT is indicative of which of the following antithrombotic agents?
A. Prasugrel
B. Clopidogrel
C. Aspirin
D. Heparin

96
Q

Screening tests for thrombophilia should be performed on:
A. All pregnant women because of the risk of thrombosis
B. Patients with a negative family history
C. Patients with thrombotic events occurring at a young age
D. Patients who are receiving anticoagulant therapy

A

Patients with thrombotic events occurring at a young age

97
Q

Prothrombin G20210A is characterized by which of the following causes and
conditions?
A. Single mutation of prothrombin molecule/bleeding
B. Single mutation of prothrombin molecule/thrombosis
C. Decreased levels of prothrombin in plasma/thrombosis
D. Increased levels of prothrombin in plasma/bleeding

A

Single mutation of prothrombin molecule/thrombosis

98
Q

Factor V Leiden promotes thrombosis by preventing:
A. Inactivation of factor Va
B. Activation of factor V
C. Activation of protein C
D. Activation of protein S

A

Inactivation of factor Va

99
Q

What is the approximate incidence of antiphospholipid antibodies in the general
population?
A. Less than 1%
B. 1%–2%
C. 3%–8%
D. 10%–15%

100
Q

Which of the following laboratory tests is helpful in the diagnosis of aspirin resistance?
A. APTT
B. PT
C. PLT count and morphology
D. PLT aggregation

A

PLT aggregation

101
Q

Which of the following complications may occur as a result of decreased tissue factor
pathway inhibitor (TFPI)?
A. Increased episodes of hemorrhage
B. Increased risk of thrombosis
C. Impaired PLT plug formation

A

Increased risk of thrombosis

102
Q

Factor VIII inhibitors occur in
__________
of patients with factor VIII deficiency.
A. 40%–50%
B. 30%–40%
C. 25%–30%
D. 20%–25%

103
Q

Which therapy and resulting mode of action are appropriate for the treatment of a
patient with a high titer of factor VIII inhibitors?
A. Factor VIII concentrate to neutralize the antibodies
B. Recombinant factor VIIa (rVIIa) to activate factor X
C. Factor X concentrate to activate the common pathway
D. FFP to replace factor VIII

A

Recombinant factor VIIa (rVIIa) to activate factor X

104
Q

The Bethesda assay is used for which determination?
A. Lupus anticoagulant titer
B. Factor VIII inhibitor titer
C. Factor V Leiden titer
D. Protein S deficiency

A

Factor VIII inhibitor titer

105
Q

Hyperhomocysteinemia may be a risk factor for:
A. Bleeding
B. Thrombocythemia
C. Thrombosis
D. Thrombocytopenia

A

Thrombosis

106
Q

Which drug may be associated with DVT?
A. Aspirin
B. tPA
C. Oral contraceptives
D. Clopidogrel (Plavix)
Hemostasis/Appl

A

Oral contraceptives

107
Q

Argatroban may be used as an anticoagulant drug in patients with:
A. DVT
B. Hemorrhage
C. TTP
D. Thrombocytosis

108
Q

Heparin-induced thrombocytopenia (HIT) results from:
A. Antibodies to heparin
B. Antibodies to PLTs
C. Antibodies to PF4
D. Antibodies to heparin–PF4 complex

A

Antibodies to heparin–PF4 complex

109
Q

Which laboratory test is used to screen for APCR?
A. Mixing studies with normal plasma
B. Mixing studies with factor-deficient plasma
C. Modified APTT with and without APC
D. Modified PT with and without APC

A

Modified APTT with and without APC

110
Q

Ecarin clotting time may be used to monitor:
A. Heparin therapy
B. Warfarin therapy
C. Fibrinolytic therapy
D. Bivalirudin

A

Bivalirudin

111
Q

Which of the following may interfere with the APCR screening test?
A. Lupus anticoagulant
B. Protein C deficiency
C. AT deficiency
D. Protein S deficiency

A

Lupus anticoagulant

112
Q

Thrombophilia may be associated with which of the following disorders?
A. Afibrinogenemia
B. Hypofibrinogenemia
C. Factor VIII inhibitor
D. Hyperfibrinogenemia

A

Hyperfibrinogenemia

113
Q

Which of the following anticoagulant drugs can be used in patients with HIT?
A. Warfarin
B. Heparin
C. Aspirin
D. Argatroban

A

Argatroban

114
Q

Which of the following is the preferred method to monitor heparin therapy at the point
of care during cardiac surgery?
A. APTT
B. ACT
C. PT
D. TT

115
Q

Mrs. Smith has the following laboratory results and no history of bleeding:
APTT = prolonged
APTT results on a 1:1 mixture of the patient’s plasma with normal plasma:
Preincubation: prolonged APTT
2-hour incubation: prolonged APTT
These results are consistent with:

A. Factor VIII deficiency
B. Factor VIII inhibitor
C. Lupus anticoagulant
D. Protein C deficiency

A

Lupus anticoagulant

116
Q

Which test may be used to monitor LMWH therapy?
A. APTT
B. INR
C. Anti–factor Xa heparin assay
D. ACT

A

Anti–factor Xa heparin assay

HEMATOLOGY 2 (3 decks)

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