Hardy Weinburg

Question 1

What assumptions are made in H/W?

Answer 1

• large population with random mating

- genotype frequencies remain constant from one generation to the next (no selection, no migration, no mutation)

Question 2

What is the H/W eqn?

Answer 2

(p+q)^2 = p^2 + 2pq + q^2 = 1

Question 3

What is p in the H/W eqn?

Answer 3

allele frequency of common allele

Question 4

What is p^2 in the H/W eqn?

Answer 4

genotype frequency of common allele homozygotes

Question 5

What is q in the H/W eqn?

Answer 5

allele frequency of rare allele

Question 6

What is q^2 in the H/W eqn?

Answer 6

genotype frequency of rare allele homozygotes

Question 7

What is 2pq in the H/W eqn?

Answer 7

gentoype frequency of heterozygotes

Question 8

What assumption should be made in x-linked recessive diseases?

Answer 8

q = disease freq. in males

Question 9

T or F: H/W is good for autosomal dominant diseases?

Answer 9

False - good for autosomal recessive diseases

Question 10

What assumption is made for rare alleles in H/W eqn?

Answer 10

p ~ 1