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oncogenes and tumor suppresor genes > Hard Things To Remember > Flashcards

Hard Things To Remember Flashcards

1
Q

MEN 1

A

Pituitary adenoma
Pancreatic adenoma
Parathyroid adenoma

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2
Q

MEN2A

A

Parathyroid hyperplasia
Thyroid (medullary thyroid carcinoma)
Pheochromocytoma

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3
Q

MEN2B

A

Thyroid (medullary carcinoma)
Pheochromocytoma
Mucosal neuromas

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4
Q

ALK

A

Thyrosin kinase

Lung adenocarcinoma

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5
Q

BCL-2

A

Antiapoptotic molecule

Follicular lymphoma
Diffuse large B cell lymphoma

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6
Q

C-KIT

A

Cytokine receptor

GIST

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7
Q

C-myc

A

Transcription factor

Burkitt lymphoma

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8
Q

HER-2/neu

A

Thyrosin kinase

Breast cancer Gastric carcinoma

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9
Q

MYCL-1

A

Transcription factor

Lung cancer

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10
Q

MYCN

A

Transcription factor

Neuroblastoma

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11
Q

RET

A

Thyrosin kinase
Medullary thyroid carcinoma
MEN2A MEN2B

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12
Q

BRAF

A

Serine threonin kinase
Malona
Non hodkings lymphoma

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13
Q

KRAS

A

GTPase
Colon
Lung. Cancer
Pancreatic

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14
Q

JAK-2

A

Thyrosin kinase

Chronic myeloproliferative disorder

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15
Q

BCR-ABL

A

Thyrosin kinase

CML/ ALL

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16
Q

APC

A

Tumor suppressor gene
Familiar adenomatous polyposis
(Colorectal cancer - brain tumors- Desmoid and osteomas)

17
Q

BRCA1/ BRCA2

A

Tumor suppressor gene

Breast ovarian cancer

18
Q

CDKN2A

A

Tumor suppressor gene
Pancreatic cancer
Melanoma

19
Q

DCC

A

Tumor suppressor gene

Colon cancer

20
Q

DPC4/SMAD 4

A

Tumor suppressor gene

Pancreatic cancer

21
Q

PTEN

A

Tumor suppressor gene
Breast cancer
Prostate cancer
Endometrial cancer

22
Q

Rb

A

Retinoblastoma

Osteosarcoma

23
Q

TP53

A

Tumor suppressor gene

Li-Fraumeni syndrome (sarcoma breast cancer brain tumor adrenocortical carcinoma leukemia)

24
Q

VHL

A

Tumor suppressor gene

von-Hippel-lindau ( hemangioblastoma renal cell carcinoma pheochromosytoma )

25
Q

MSH2/MLH1

A

Lynch syndrome ( colorectal cancer endometrial cancer ovarian cancer )

oncogenes and tumor suppresor genes (1 decks)

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