HAP - Kidneys up to 48 mins on lecture capture but oh so dull.... Flashcards

1
Q

Name the 3 main parts of the urinary system…

A

Kidneys (renal organs as part of the urinary system)

Bladder

Adrenal glands

[REVISE THE DRAINAGE OF BLOOD AND THE CYCLE OF THE RENAL SYSTEM]

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2
Q

Why is the rib cage situated in front of the kidneys?

A

For protection - the kidneys are SO necessary as they are involved in every process in the body - one of the most important organs. A CORE ORGAN.

NOTE the inferior vena cava is identifiable as a VEIN because of its thinness compared to the descending AORTA which is larger.

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3
Q

Anatomy of kidneys - position and relations…[a transverse cross section]

Why do we have peri-renal fat?

A

Peri-renal fat - provides insulation and protection (eg from a rabbit punch!!)

kidneys sit outside of the peri-tineal cavity (the blue line in the diagram).

Retro = behind.

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4
Q

Why are the kidneys slightly difference in shape?

A

Because the position of the liver on the right side of the body needs to make room so is forced into a different position.

The left kidney shape is slightly different (squished) due to the spleen.

Bottom two ribs protect the kidneys.

The ureters are not protected.

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5
Q

What does caudal mean?

A

Towards the tail [down toward the toes]

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6
Q

What is the hilus?

(sp?)

A

The ureter is connected to the kidneys by the hilus.

” the point at which the stem inserts”

  • The point at which the stem punctures a kidney bean.
  • The point at which the ureter punctures the kidney.
  • The point at which the oesophagus the diaphragm.
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7
Q

Name the 5 layers of the muscles involved with peristalsis and the specialist tissue which lines it…..

A

Muscularis
Circular
Longitudinal muscle layer
Mucosa
Sub mucosal

Uro epithelial (uro - easily replaced) used to pump urine down to the bladder.

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8
Q

Where are the kidneys situated in relation to the spinal veterbrae?

A

Around L2 - T12

remember there re 2 x 2’s!!! —–L2 and T12

Lower end of thoracic and upper end of lumbar.

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9
Q

What is the main function of the ureters?

A

They carry urine from the kidneys to the bladder.

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10
Q

How long are the ureters?

A

They are approx 25cm long.

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11
Q

What makes up the lining of the ureters?

A

Smooth muscle lined with uro-epi-thelium

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12
Q

What are the common layers of the ureter? And where else can we find these layers?

A

Common layers found in the ureters are:

transitional epithelium (lines the lumen and is innermost layer)

Mucosa

Muscularis

Adventitia (outermost layer)

Peristalsis pumps urine into the bladder.

These muscles are also found in the GI tract.

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13
Q

How do the ureters pump urine into the bladder?

A

Peristalsis pumps urine into the bladder.

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14
Q

How long is a ureter?

And which muscle is it lined with?

A

Around 25cm long and straight down, lined with uro epi thelium

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15
Q

Major components of the human kidney

A

Medulla
Pelvis
Hilum
Cortex
Ureter

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16
Q

Define the medulla?

A

Individual lobes within the kidney (triangle)
There is species variation according to their structure.

The main function of the medulla is to regulate concentration of the urine. The urine flows from the collecting ducts into the renal calyces and pelvis, which undergoes unidirectional peristaltic movements to allow drainage of the urine into the downstream ureter and bladder.

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17
Q

KNow the blood supply to the kidneys STEPS
[insert pic from slides]

Nephrons are where the functioning begins….

Names are according to where they are positioned.

Know which lobes are holding which lobes.

A

Blood vessels get smaller the closer they get to the centre of the kidney - this is so that waste is PUSHED out with pressure from being in a smaller space.

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18
Q

Drainage
[pic here]

A

collecting ducts drain through an entire pyramid and drain into minor calyx
(approx 20-25) into major calyx

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19
Q

Nephrons

A

Cortical and Juxtamedullary nephrons (names so as it crosses the border)

Looooops of Hennnnnnnnnnleeeeeeeeeeeeee

20
Q

Why do we have millions of nephrons?

A

Back up!! They have a lot of work to do.

They are the renal version of the alveoli!

Nephrons are little blood vessels that push out stuff into the Bowman’s capsule which drains into the collecting ducts.

21
Q

Epithelial podocytes

A

Filtration goes through the epithelial podocytes

22
Q

Bowman’s SPACE is within the Bowman’s CAPSULE

A

It is a collecting space.

23
Q

Define:

  1. Colloid osmotic pressure
  2. Blood hydrostatic pressure
  3. Capsular hydrostatic pressure
A

Osmosis - how much water is on each side.

Oncotic pressure “osmosis with bits”.

  1. Colloid osmotic pressure - osmosis does not stop just because there are “bits” in the fluid. Oncotic pressure happens and the net pressure is enough to maintain the blood pressure [NOT SURE ABOUT THIS - CHECK RECORDING @1053].
    2.
24
Q

REABSORBTION

A

Pulls back molecules across the membranes

25
Q

The Loop of Henle

A

Water is mediated by sodium chloride (NACl)

LofH determines what will be urine and what will be blood to maintain BP.

Conc urine - salt content is too much.

Can either add more water or can add sodium chloride into urine rather than diluting the salt with water.

26
Q

What is the final stage…..

A

Distal convoluted tubule and collecting duct.

27
Q

Describe diabetes insipidus

A

A water imbalance and excessive amounts of dilute urine.

Nocturesis - wetting the bed.

If there is an excessive amount of water being taken in, there is more output and there is a problem with the collecting ducts. They SHOULD retain water to maintain the pressure.

28
Q

Hypo - too much in

Hyper - too little

Isto - just right

A
29
Q

Pituitary effects ADH

A
30
Q

Label the diagram

A
31
Q

Name the layers of the ureter…

And where else can we find these layers?

A

Common layers of the ureter:

mucosa

muscularis

Where else can we find these layers? GIT

32
Q

Name the 6 major components of the human kidney

A

Medulla

Pelvis

Hilum

Cortex

Capsule

Ureter

33
Q

Pinpoint the following in the diagram:

Diaphragm

Kidney

Inferior vena cava

Adrenals

Descending aorta

A
34
Q

Are kidneys regenerative?

A

Nope.

35
Q

Where do the adrenal glands sit:

lateral to liver

cranial poles

caudal median

A

cranial poles

36
Q

The kidneys are outside of the digestive process. True or false?

A

True

37
Q

The main blood supply to the kidneys is:

A

The abdominal aorta

Paired arteries and renal arteries pair with each side

(????)

Blood into kidneys - reduces blood volume by urinating water and then this lowers blood volume and blood pressure.

38
Q

The kidneys have the ability to change sodium content, blood pressure and water volume. True or false

A

True. BUT it shouldn’t be left to them. It should be done further up the chain.

39
Q

Blood supply to the kidneys…..

A
40
Q

What do the kidneys do best?

A

Filtration

(there is a more detailed answer on this later on….)

41
Q

Name the two types of nephrons

A

Cortical nephron - crosses the border of the cortex and the medulla. The location effects the length of the Loops of Henle.

Juxtamedullary nephron - close to the medulla

42
Q

Drainage of the kidneys

A
43
Q

Which two systems help the kidneys maintain a balance with blood composition, blood pressure, solutes and drug metabolism?

A

Two major pathways:

Hypothalamaus responds and produces ADH in posterior pituitary.

or

Kidneys release renin which goes through the RAS to convert angiotensin 1 or angiotensin 2.

Angiotensin 1 =

Angiotensin 2 =

Renin travels through the system to the adrenal glands, this releases aldosterone in the collecting ducts which then changes the sodium absorption which makes the blood more or less salty and in turn this takes in more or less water.

44
Q

What does ADH stand for?

A

Anti Diuretic Hormone determines how much water needs to be removed and excreted as urine to help control blood volume and pressure.

45
Q

What does RAAS stand for?

A

Renin angiotensin aldosterone system.

46
Q

Name three diuretics….

A

Drugs - px to treat hypertension. The body will take what it needs and excrete the rest.

Coffee - interferes with NA+ absorption

Alcohol - inhibits ADH secretion

47
Q

What do the kidneys actually do?

A

Regulate extracellular fluid volume

Regulate ion concentrations (eg increased levels of potassium can give a heart attack as it overloads the heart. the kidneys will aim to kick out what they can but it’ll be too much to handle)

pH

production of hormones

excretion of waste and toxins

A blood processing centre