Handout Part 4 (Hydrolysis) Flashcards
1
Q
What is hydrolysis?
A
A chemical reaction in which water reacts with a compound to produce other compounds.
2
Q
What does hydrolysis involve?
A
Splitting of a chemical bond and the addition of the proton (H+) and the hydroxide anion (HO-) from the water.
3
Q
Order these in the quickest rate of hydrolysis to the slowest:
Ester, Amide, Carbamate, Carbonate
A
Ester
Carbonate
Carbamate
Amide
4
Q
What factors affect the Hammett sigma parameter?
A
Resonance and inductive effects on X
5
Q
The smaller the sigma value the _____ the pKa will be compared to the reference. The more ____ the smaller the sigma value.
A
Greater
Basic
6
Q
According to the Hammett equation Rho is in reference to what?
A
The reaction constant.
