Haloperidol

Question 1

What is the brand/trade name for haloperidol?

Answer 1

• Haldol

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Haloperidol: Drug Information}

Question 2

What is the pharmacologic category/class of haloperidol?

Answer 2

• 1st generation (typical) antipsychotic Antiemetic
• Butyrophenone

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Haloperidol: Drug Information}

Question 3

What is the mechanism of action of haloperidol?

Answer 3

• Blocks dopamine receptors throughout the brain, including at the CTZ/vomiting center

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Haloperidol: Drug Information}

Question 4

What is the standard dose of haloperidol for PONV prophylaxis or rescue therapy?

Answer 4

• 0.5-2 mg

Equal efficacy when administered at beginning or end of surgery

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Haloperidol: Drug Information}

Question 5

What is the onset of action for haloperidol?

Answer 5

• ~5-20 minutes

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Haloperidol: Drug Information}

Question 6

What is the duration of action for haloperidol?

Answer 6

• 3-24 hours

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Haloperidol: Drug Information}

Question 7

The use of haloperidol and other dopamine antagonists should be avoid in patients with ____________

Answer 7

• Parkinson’s disease

Risk for causing or worsening extrapyramidal symptoms

_{Anesthesia Guidebook - Episode 19: Anesthesia Top Drawer Run Down - Part 3
UpToDate - Haloperidol: Drug Information}