Haemostasis and Thrombosis

Question 1

What is the proportion of blood cells and plasma in blood?

Answer 1

45% blood cells - out of which, 99% erythrocytes

55% blood plasma - out of which, 90% water

Question 2

In a rest scenario, does blood lean towards clotting or bleeding?

Answer 2

Clotting

Question 3

What are the constituents of blood?

Answer 3

Blood cells

Plasma clotting factors: pro and anti coagulants

Question 4

***What is haemostasis

Answer 4

Physiological blood clotting process

Question 5

What is the pathophysiology of thrombosis

Answer 5

Initial stages:
Molecular level - small scale thrombin production
1. Tissue factor
TF bearing cells activate factors X and V forming prothrombinase complex
2. Prothrumbinase complex activates factor II (prothrombin) creating factor IIa (thrombin)
3. Antithrombin (AT-III) inactivates thrombin by breaking it back down to prothrombin