Haemostasis Flashcards

1
Q

What are the elements of the haemostatic response? (5)

A
  1. Blood vessels - vasoconstriction
  2. Platelets - platelet plug formation
  3. Clotting factors - coagulation phase
  4. Coagulation inhibitors
  5. Fibrinolysis
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2
Q

What does haemostasis balance?

A

Excessive bleeding Vs excessive clotting

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3
Q

What is the most immediate protection against blood loss?

A

Vasoconstriction

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4
Q

How long does vasoconstriction last?

A

A few seconds - minute

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5
Q

What chemical is released from platelets?

A

Serotonin

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6
Q

Where are platelets produced?

A

Bone marrow

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7
Q

What are platelets made from?

A

Fragments of megakaryocyte cytoplasm (1 makes 4000)

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8
Q

What is platelet production controlled by?

A
  • Number of circulating platelets (negative feedback)

- Thrombopoietin (TPO) released (increases platelet numbers)

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