Haemopoiesis Flashcards

1
Q

Causes of massive splenomegaly

A

Chronic myeloid leukaemia
Myelofibrosis
Malaria
Schistosomiasis

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2
Q

Moderate

A
Lymphoma 
Leukaemia 
Myeloproliferative disorders 
Liver cirrhosis - portal hypertension 
Glandular fever - EBV
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3
Q

Mild splenomegaly

A

Infective hepatitis
Endocarditis
Infiltrative disorders - sarcoidosis
Autoimmune- autoimmune haemolytic anaemia, SLE

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4
Q

Globing Gene

A

Chromosome 11 and 16

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5
Q

Red blood cell structure

A

Ankyrin connects Band 3 to spectrin to prevent flip flop

Band 4.1 connects spectrin to glycophorin A - restricts lateral movement and flip flop

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