Haemopoiesis Flashcards
What is haemopoiesis?
The process through which the formed elements of the blood develop
Where do the adult stem cells which differentiate into blood cells reside?
The red bone marrow
How does ageing affect the number of haemopoetic stem cells?
Ageing decreases the number of haemopoetic stem cells
The common myeloid progenitor cell eventually gives rise to which types of blood cells?
Erythrocytes Monocytes Neutrophils Eosinophils Basophils Megakaryocyte
What is the name of the stem cell from which all blood cells arise?
Multipotent haemopoietic stem cell
What are the different cells in the stages of erythropoiesis, in order from least differentiated to most differentiated?
Multipotent haemopoietic stem cell Myeloid progenitor Pronormoblast/proeryhtroblast Early normoblast/basophilic erythroblast Intermediate normoblast/ polychromatic erythroblast Late normoblasts/ orthochromatic eryhtroblasts Reticulocytes Erythrocytes
At which stage of differentiation are erythrocytes released into the blood stream?
At the reticulocyte stage
What hormone regulates erythropoiesis?
Erythropoietin (EPO)
At what point in haemopoiesis does the developing red blood rid itself of organelles?
At the reticulocyte stage
What is the name of the stem cell from which B lymphocytes, T lymphocytes and NK cells arise from?
Common lymphoid progenitor cell
What two types of cell can monocytes differentiate into?
Macrophages
Dendritic cells
What is the name of the process in platelet production where the megakaryocyte undergoes DNA replication without cell division?
Endomitosis
Where is EPO mainly synthesised?
The kidneys
