Haemolytic Anaemias Flashcards
1
Q
What are the causes of hereditary haemolytic anaemias?
A
- Hereditary spherocytosis
- G6PD deficiency
- haemoglobinopathies: sickle cell, thalassaemia
2
Q
What are acquired immune causes of haemolytic anaemias?
A
- Autoimmune: warm/cold antibody
- alloimmune: transfusion reaction, haemolytic disease newborn
- Drugs: methyldopa, penicillin
3
Q
What are haemolytics anaemias caused by?
A
The increased destruction of red cells
4
Q
What are the sites of haemolysis?
A
- extravascular (more common)
* intravascular
5
Q
What evidence demonstrates haemolysis?
A
*
6
Q
What are acquired non-immune causes of haemolytic anaemias?
A
- Pre-eclampsia
- DIC
- Malignancy
- Prosthetic cardiac valves
- Malaria
- HUS
7
Q
What is the difference between warm and cold autoimmune haemolytic anaemia?
A
- According to what temperature the antibodies haemolyse
- Warm = haemolyse best at body temp
- cold haemolyse best at 4degrees
