Haematology Crash Course Flashcards
Unexplained iron-deficiency anaemia
Causes a microcytic anaemia with low ferritin
Men and post-menopausal women - urgent gastroscopy and colonoscopy
Microcytic anaemia causes
Iron deficiency
Chronic disease
Thalassaemia
Recurrent nosebleeds and new red lesions on the skin and lips?
What investigations?
Full blood count - platelets!
Most likely diagnosis is…
ITP is due to the formation of auto-antibodies against…
Platelet antigens
It is an acquired bleeding disorders due to low platelets
May be primary or secondary
Low platelets lead to petechiae, purpura and recurrent bleeding
ITP vs TTP
Most likely diagnosis? - Hodgkin? AML? ALL? CML? CLL?
Chronic lymphocytic leukaemia
Malignant clonal disorders of B cells that causes high white cells and lymphadenopathy
Malignant clonal disorders of B cells that causes high white cells and lymphadenopathy?
Chronic lymphocytic leukaemia
Commonest leukaemia - 60-80years old
Generally slow and indolent malignancy of unknown aetiology
Watch and wait
Leukaemia overview
ALL typically in
Children
Treatment for CML
TKI (e.g. imatinib)
AML vs CML
Massive splenomegaly, lethargy and night sweats…
CML
Bone marrow failure (adults?)
AML
A
Sickle cell disease
Autosomal recessive inherited
Sickle Hb is due to a point mutation in the beta-glob in gene