Haematology Crash Course Flashcards

1
Q

Unexplained iron-deficiency anaemia

A

Causes a microcytic anaemia with low ferritin

Men and post-menopausal women - urgent gastroscopy and colonoscopy

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2
Q

Microcytic anaemia causes

A

Iron deficiency
Chronic disease
Thalassaemia

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3
Q

Recurrent nosebleeds and new red lesions on the skin and lips?
What investigations?

A

Full blood count - platelets!

Most likely diagnosis is…

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4
Q

ITP is due to the formation of auto-antibodies against…

A

Platelet antigens
It is an acquired bleeding disorders due to low platelets
May be primary or secondary
Low platelets lead to petechiae, purpura and recurrent bleeding

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5
Q

ITP vs TTP

A
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6
Q
Most likely diagnosis?
- Hodgkin?
AML?
ALL?
CML?
CLL?
A

Chronic lymphocytic leukaemia

Malignant clonal disorders of B cells that causes high white cells and lymphadenopathy

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7
Q

Malignant clonal disorders of B cells that causes high white cells and lymphadenopathy?

A

Chronic lymphocytic leukaemia
Commonest leukaemia - 60-80years old
Generally slow and indolent malignancy of unknown aetiology
Watch and wait

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8
Q

Leukaemia overview

A
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9
Q

ALL typically in

A

Children

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10
Q

Treatment for CML

A

TKI (e.g. imatinib)

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11
Q

AML vs CML

A
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12
Q

Massive splenomegaly, lethargy and night sweats…

A

CML

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13
Q

Bone marrow failure (adults?)

A

AML

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14
Q
A

A

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15
Q

Sickle cell disease

A

Autosomal recessive inherited

Sickle Hb is due to a point mutation in the beta-glob in gene

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16
Q

Sickle Hb polymerises at … tension, which distorts its shape and causes ….

A

Sickle Hb polymerises at low O2 tension, which distorts its shape and causes vaso-occlusion

17
Q
Low Hb
High urea and creatinine
High K+ and calcium
High CRP
Para protein detected on protein electrophoresis
What next?
A

Bone marrow biopsy

Myeloma

18
Q

Multiple myeloma

A

Malignant disorder of plasma cells (mature b lymphocytes)
Characterised by excess secretion of a monoclonal antibody
CRAB (high calcium, renal impairment, anaemia, boney disease)

19
Q

Definitive diagnosis of multiple myeloma

A

Bone marrow biopsy

20
Q

Diagnostic criteria

MGUS, smouldering, myeloma

A
21
Q

High Hb + stroke

What investigation to confirm cause of stroke?

A

JAK2 mutation

Polycythaemia vera - myeloproliferative disorder characterised by an elevated red cell mass

22
Q

Polycytheamia Vera

A
23
Q

What is found in 98% of people with primary polycythaemia Vera?

A

JAK2

24
Q

Complications of polycythaemia

A
25
Q

What next?

A

Arrange an US doppler of the left leg

26
Q

DVT suspected

A

Deep veins of lower limb
Wells score - risk of DVT
If likely >2, straight to US within 4 hours
D diner if less than 1

27
Q
A

Vitamin B12/folate deficiency likely

28
Q

Macrocytic anaemia

A
29
Q
CLL
FL
MS
HL
Aplastic anaemia?
A

Hodgkin lymphoma

30
Q

Hodgkin lymphoma

A

Reed stern burg cells

31
Q

Aplastic anaemia

A

Abnormal EPO in bone marrow, reduced red cells

32
Q

Lymphoma

A

Hodgkin’s and non-hodgkins
Hodgkins - reed sternberg cells
Painless lymphadenopathy and B symptoms
Lymph node biopsy to diagnose!