Haematology and oncology

Question 1

Acute intermittent porphyria inheritance

Answer 1

AD

Question 2

Antithrombin III deficiency inheritance

Answer 2

AD

Question 3

1. Beta-thalassaemia major
2. ALL good and poor prognostic mutations
3. AML good and poor prognostic mutations
4. Alpha-thalassaemia
5. Burkitt’s lymphoma

Answer 3

1. Beta-thalassaemia major - chromosome 11
2. ALL del(9p) - good prognosis
   Philadelphia translocation, t(9;22) - poor prognosis
3. AML APML M3 t(15;17) - good prognosis
   AML del chr 5 or 7 - poor prognosis
4. Alpha-thalassaemia - chromosome 16
5. Burkitt’s lymphoma - t(8:14).

Question 4

Beta-thalassaemia trait inheritance

Answer 4

AR