Haematology Flashcards
Most common cause of osteomyelitis in SCD
Salmonella
Most common human platelet antigen in NAIT
HPA-1a
Extrinsic Pathway (factors and test)
Tissue factor and Factor 7, PT
Intrinsic Pathway (factors and test)
Factors 12, 11, 9, 8 (aPTT)
What is FFP usually given for?
DIC - all factors effected (extrinsic and intrinsic. Preferred option over cryoprecipitate)
What is the most sensitive test for Vit B12 deficiency?
Elevated serum (or urine) MMA (methylmalonic acid)
Cryoprecipitate is indicated for replacement of:
Fibrinogen. Cryoprecipitate is FFP that has been centrifuged and contains F8, fibrinogen, fibronectin and F13 (in greater concentrations than those in plasma)
Prolonged aPTT which normalises with mixing study is most likely a diagnosis of?
Haemophilia
Bone marrow failure, oral leukoplakia and a lacy appearance to skin
Dyskeratosis congenita
What is the mechanism of hydroxyurea
Increases HbF production
Reed-Sternberg Cells
Hodgkin Lymphoma
Auer Rods
AML
Spherocytes and DAT neg
Hereditary Spherocytosis
Spherocytes and DAT positive
AIMA
What is the genetic mutation causing SCD?
Missense mutation on the surface os Hb S molecule in the beta globin chain. This mutation results in a substitution of valine (in) for glutamic acid (out) i.e. GTG to GAG.
Bite cells, Blister cells and Heinz Bodies
G6PD
Tear drop cell
Vit B12 def
Elliptocyte/Pencil cell
IDA
What is Haemophilia C and how is it inherited?
Factor 11 def. Autosomal recessive inheritance
What is the reason for a high serum homocysteine but normal serum MMA?
Folate def (they would both be raised in Vit B12 def)
Microcytic, hypochromic + target cells
Thalassemia
Normocytic, normochromic + spherocytes
HS
Macrocytic, normochromic + ovalcytes
Megaloblastic anaemia
