Haematology Flashcards
What clotting factor is abnormal in Haemophilia A?
Factor VIII (8)
What is the genetic inheritance pattern for Haemophilia A?
X linked recessive
What coagulation measurement is abnormal in haemophilia A and why?
APTT is prolonged. APTT is a measurement of the intrinsic pathway which factor VIII is part of
A patient requires immediate blood. He is found to be B+. What blood products is he able to receive? He requires packed RBC and FFP.
He is able to receive
RBC: B+/B- and O+/O-
FPP: B+/B- or AB
B symptoms are a constellation of symptoms typically found in lymphomas. What are these?
Fevers, night sweats, weight loss (>10% over 6 months)
The presence of these at the time of presentation typically indicate a worse prognosis
What is the most common subtype of Hodgkins Lymphoma?
What subtype of lymphoma offers the best prognosis?
Nodular Sclerosis: accounts for 70%
Lymphocyte rich
What is the virus that is most commonly associated with triggering an aplastic crisis?
Parovirus-19
A known sickle cell patient presents with acute shortness of breath. O2 sats are decreased and CXR demonstrates bilateral infiltrates. What type of sickle crisis is he/she experiencing?
Acute chest syndrome
Which blood type is the universal donor?
O-
How is the severity of haemophilia assessed?
The severity of the disease is dependent in the levels of each of the factors.
Mild >5%-50%,
Mod <5%
Severe <1%
Which is the key clotting factor involved in the intrinsic pathway?
Factor VII (7)
What is the difference between Hodgkins and Non-Hodgkins Lymphoma
The only difference is the presence or absence of Reed-Steinberg cells
Staging of HL is done via which imaging modality? What is assessed when looking at the scan?
CT Scan. Looking for the presence of abnormal lymph nodes, whether or not they’re in more than one region and whether they are on one or two sides of the diaphragm.
What clotting factor is abnormal in Haemophilia B?
Factor IX (9)
What age do homozygous sickle cells patients typically present and why?
they don’t tend to develop symptoms until after 4 months due to the presence of foetal Hb.
