Haematological malignancy 3

Question 1

A 60 year old man presents with a painless, rubbery lump in his neck. He mentions he has lost 3kg over the last month and finds he drenches the bed with sweat at night.

Further examination reveals splenomegaly and axillary lymphadenopathy.

What it the most likely diagnosis?

Answer 1

Non-Hodgkin lymphoma

Question 2

Clinical features of non-Hodgkin lymphoma

Answer 2

• Symptoms
  
  • B symptoms
    
    • Fever
    • Weight loss
    • Night sweats
• Signs
  
  • Lymphadenopathy
    
    • Painless
    • Hard
    • Rubbery
    • Fixed
    • Non-contiguous spread unlike in HL
  • Splenomegaly
    
    • More common in NHL compared to HL
  • Extranodal disease: bone marrow, thyroid, salivary gland, GI tract, CNS