Haematological malignancy

Question 1

Mutant plasma cell clonal malignancy?

Answer 1

Myeloma

Question 2

Characteristic appearance of myeloma on blood film?

Answer 2

Rouleaux formation

Question 3

10 yr survival of myeloma?

Answer 3

33%

Question 4

Commonest form of acute leukaemia in adults?

Answer 4

Acute myeloid leukaemia

Question 5

Bone pain occurs in which acute leukaemia?

Answer 5

ALL only

Question 6

Skin infiltration (leukaemia cutis) occurs in which acute leukaemia?

Answer 6

AML only

Question 7

Monitoring of patients with CLL?

Answer 7

6-monthly FBC

Question 8

Chromosomal abnormality in CML?

Answer 8

philadelphia chromosome t(9;22)

Question 9

Management of chronic-stage CML?

Answer 9

Tyrosine kinase inhibitors

Question 10

JAK2 mutation is associated with…?

Answer 10

Polycythaemia vera

Question 11

Progressive accumulation of fibrous tissue in the bone marrow, causing haematopoesis to be taken over by the spleen?

Answer 11

Myelofibrosis

Question 12

Myelofibrosis can progress to..?

Answer 12

AML

Question 13

What are the four myeloproliferative disorders?

Answer 13

CLM
Myelofibrosis
Polycythaemia vera
Thrombocythaemia

Question 14

Malignancy (classically) defined by presence of Reed-Sternberg cells?

Answer 14

Hodgkin’s lymphoma