Haematological malignancies- Lymphomas Flashcards
What are lymphomas?
roup of cancers that affect the lymphocytes inside the lymphatic system. These cancerous cells proliferate within the lymph nodes and cause the lymph nodes to become abnormally large (lymphadenopathy).
cancer of the lymphatic system which starts in the lymph nodes and involves lymphocytes. can spread to bone marrow, spleen and other parts of the body
B, T and NK cells
two main categories of lymphomas
Hodgkin’s lymphoma
(nodular sclerosis, mixed cellularity, lymphocyte rich, lymphocyte depleted)
Non Hodgkin’s lymphoma
(all other lymphomas)
What is Hodgkin’s lymphoma?
1 in 5 lymphomas
proliferation of lymphocytes
bimodal age distribution
peaks around 25 and 75 y/o
Risk factors: HIV Epstein-Barr Virus Autoimmune conditions such as rheumatoid arthritis and sarcoidosis Family history
Hodgkin’s lymphoma clinical features
lymphadenopathy (enlarged lymph nodes in neck, axilla, inguinal region)
non tender
ruberry
pain (when they drink alcohol)
B symptoms are the systemic symptoms of lymphoma:
Fever
Weight loss
Night sweats
Fatigue Itching Cough Shortness of breath Abdominal pain Recurrent infections
Hodgkin’s lymphoma investigations
Lactate dehydrogenase (LDH) is a blood test that is often raised in Hodgkin’s lymphoma but is not specific and can be raised in other cancers and many non-cancerous diseases.
Lymph node biopsy is the key diagnostic test.
The Reed-Sternberg cell is the key finding from lymph node biopsy in patients with Hodgkin’s lymphoma. They are abnormally large B cells that have multiple nuclei that have nucleoli inside them. This can give them the appearance of the face of an owl with large eyes. The Reed-Sternberg cell is a popular feature in medical exams.
CT, MRI and PET scans can be used for diagnosing and staging lymphoma and other tumours.
Ann Arbor Staging
The Ann Arbor staging system is used for both Hodgkins and non-Hodgkins lymphoma. The system puts importance on whether the affected nodes are above or below the diaphragm. A simplified version is:
Stage 1: Confined to one region of lymph nodes.
Stage 2: In more than one region but on the same side of the diaphragm (either above or below).
Stage 3: Affects lymph nodes both above and below the diaphragm.
Stage 4: Widespread involvement including non-lymphatic organs such as the lungs or liver.
Management of lymphoma
The key treatments are chemotherapy and radiotherapy. The aim of treatment is to cure the condition. This is usually successful however there is a risk of relapse, other haematological cancers and side effects of medications.
Chemotherapy creates a risk of leukaemia and infertility.
Radiotherapy creates a risk of cancer, damage to tissues and hypothyroidism.
Non-Hodgkin lymphoma
Burkitt lymphoma is associated with Epstein-Barr virus, malaria and HIV.
MALT lymphoma affects the mucosa-associated lymphoid tissue, usually around the stomach. It is associated with H. pylori infection.
Diffuse large B cell lymphoma often presents as a rapidly growing painless mass in patients over 65 years.
risk factors for non-Hodgkin’s lymphoma
HIV Epstein-Barr Virus H. pylori (MALT lymphoma) Hepatitis B or C infection Exposure to pesticides and a specific chemical called trichloroethylene used in several industrial processes Family history
The presentation is similar to Hodgkin’s lymphoma and often they can only be differentiated when the lymph node is biopsied.
Management of Non-Hodgkin’s lymphoma
Management involves a combination of treatments depending on the type and staging of the lymphoma:
Watchful waiting Chemotherapy Monoclonal antibodies such as rituximab Radiotherapy Stem cell transplantation
