Haematolgy 2

Question 1

Multiple Myeloma

Answer 1

plasma cell proliferation

B-lymphocyte > mature plasma cells

Question 2

diagnostic criteria for MM?

Answer 2

major :
plasmacytoma
30% plasma cells in bone marrow sample
elevated levels of M protein in blood / urine

Minor:
10% - 30% plasma cells in bone marrow sample

osteolytic lesions on XR
low levls fo antibodies in blood

Question 3

1st line imaging in MM?

Answer 3

whole body MRI

Question 4

mx of tumour lysis syndrome?

Answer 4

IV fluids
IV rasburicase
>manages uric acid levels

Question 5

most likely cause of burkitts?

Answer 5

viral : EBV

Question 6

autoimmune haemolytic anaemia + DAT

mx?

Answer 6

corticosteroids to reduce circulating antibodies

= reduces haemolysis

Question 7

IgA deficiency can lead to a common blood transfusion reaction?

Answer 7

anaphylactic reaction due to low igA = high anti-IgA abs

Question 8

parovirus in sickle cell

Answer 8

drop in haemoglobin but also markedly low reticulocyte count

> aplastic crisis

Question 9

anaemia of chronic disease

Answer 9

reduced iron release from marrow

inadequate EPO
reduced red cell

Question 10

hereditary haemochromatosis?

Answer 10

raised ferrit, low tibc

iron levels abnormal

Question 11

before starting rituximab what should be screened?

Answer 11

hepatitis B
Cd20 monoclonal antibody

used in Mx diffuse large cell lymphoma

Question 12

myelofibrosis blood film?

Answer 12

tear drop poikolcytes