Haem: Haematology Quiz Flashcards
1
Q
For each of the following blood cell parameters, state the normal range:
- Haemoglobin
- Mean Cell Volume
- Platelets
- White Blood Cells
- Neutrophils
- Lymphocytes
A
- Haemoglobin
- Men: 135-180 g/L
- Women: 115-160 g/L
- Mean Cell Volume
- 82-100 fL
- Platelets
- 150-400 x 109/L
- White Blood Cells
- 4-11 x 109/L
- Neutrophils
- 2-7 x 109/L
- Lymphocytes
- 1-3 x 109/L
2
Q
Outline the mechanisms by which anaemia of chronic disease causes anaemia.
A
- Reduced red cell lifespan
- Cytokine release (IFN-gamma, IL1, TNF)
- Reduced proliferation of erythroid precursors
- Suppression of endogenous EPO production
- Impaired iron utilisation
3
Q
How is anaemia of chronic disease treated?
A
- Treat underlying disease
- Recombinant EPO
- Transfusion may be considered in severe cases
4
Q
Describe the typical ferritin and transferrin levels you’d expect to see in anaemia of chronic disease.
A
- Ferritin - high or normal (acute phase protein)
- Transferrin - reduced
5
Q
Which HLA genotype is associated with Hodgkin lymphoma?
A
HLA-DPB1
NOTE: EBV is found in >79% of people over 50 years
6
Q
How is Hodgkin lympoma investigated?
A
- Histopathological review
- ESR for prognosis and monitoring
- CT/MRI/PET for staging