Haem: Haematology Quiz Flashcards

1
Q

For each of the following blood cell parameters, state the normal range:

  1. Haemoglobin
  2. Mean Cell Volume
  3. Platelets
  4. White Blood Cells
  5. Neutrophils
  6. Lymphocytes
A
  1. Haemoglobin
    • Men: 135-180 g/L
    • Women: 115-160 g/L
  2. Mean Cell Volume
    • 82-100 fL
  3. Platelets
    • 150-400 x 109/L
  4. White Blood Cells
    • 4-11 x 109/L
  5. Neutrophils
    • 2-7 x 109/L
  6. Lymphocytes
    • 1-3 x 109/L
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2
Q

Outline the mechanisms by which anaemia of chronic disease causes anaemia.

A
  • Reduced red cell lifespan
  • Cytokine release (IFN-gamma, IL1, TNF)
  • Reduced proliferation of erythroid precursors
  • Suppression of endogenous EPO production
  • Impaired iron utilisation
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3
Q

How is anaemia of chronic disease treated?

A
  • Treat underlying disease
  • Recombinant EPO
  • Transfusion may be considered in severe cases
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4
Q

Describe the typical ferritin and transferrin levels you’d expect to see in anaemia of chronic disease.

A
  • Ferritin - high or normal (acute phase protein)
  • Transferrin - reduced
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5
Q

Which HLA genotype is associated with Hodgkin lymphoma?

A

HLA-DPB1

NOTE: EBV is found in >79% of people over 50 years

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6
Q

How is Hodgkin lympoma investigated?

A
  • Histopathological review
  • ESR for prognosis and monitoring
  • CT/MRI/PET for staging
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