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Internal Medicine > H77:392-400-Anemia > Flashcards

H77:392-400-Anemia Flashcards

1
Q

4 characteristics to the normal RBC

A

pliable, 8 micrometers in diameter, anucleate and discoid

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2
Q

4 characteristics to the normal RBC

A

pliable, 8 micrometers in diameter, anucleate and discoid

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3
Q

what % of RBC are replaced daily

A

.8 to 1%

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4
Q

avg lifespan of RBC

A

100-120 days

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5
Q

Where is EPO produced

A

small fraction is in hepatocyes the rest is in peritubular capillary

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6
Q

How is EPO produced

A

limited O2 delivery to kidney decreases hydroxylation which then allows HIF-1alpha to initiate cellular cascade to produce EPO

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7
Q

Three ways O2 delivery is impaired

A

anemia, hypoxemia (high affinity), decreased blood flow

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8
Q

At what Hb level is EPO induced

A

10-12 then is log increased

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9
Q

What is the time course and quantity related to EPO induction ?

A

4-5 fold increase in 1-2weeks

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10
Q

A Hct lower than 35 in women and 39 in men has a ___ chance of being abnormal

A

25%

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11
Q

WHO definition of anemia

A
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12
Q

What is a general way to tell if Hb is probably below 8 ?

A

pale palmar creases with hand hyperextended

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13
Q

Condition associated with:

Burr cells

A

uremia

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14
Q

Condition associated with:

target cells

A

thalessemia

live disease

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15
Q

what two correcttoins need to be made for reticulocyte assessment

A

for anemia

for longer life of premature retics

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16
Q

what two correcions need to be made for reticulocyte assessment

A

for anemia

for longer life of premature retics

17
Q

what % of RBC are replaced daily

A

.8 to 1%

18
Q

avg lifespan of RBC

A

100-120 days

19
Q

Where is EPO produced

A

small fraction is in hepatocyes the rest is in peritubular capillary

20
Q

How is EPO produced

A

limited O2 delivery to kidney decreases hydroxylation which then allows HIF-1alpha to initiate cellular cascade to produce EPO

21
Q

Three ways O2 delivery is impaired

A

anemia, hypoxemia (high affinity), decreased blood flow

22
Q

At what Hb level is EPO induced

A

10-12 then is log increased

23
Q

What is the time course and quantity related to EPO induction ?

A

4-5 fold increase in 1-2weeks

24
Q

A Hct lower than 35 in women and 39 in men has a ___ chance of being abnormal

A

25%

25
Q

WHO definition of anemia

A
26
Q

What is a general way to tell if Hb is probably below 8 ?

A

pale palmar creases with hand hyperextended

27
Q

Condition associated with:

Burr cells

A

uremia

28
Q

Condition associated with:

target cells

A

thalessemia

live disease

29
Q

condition associated with:

tear-drop cells

A

myelofibrosis

30
Q

what two correcions need to be made for reticulocyte assessment

A

for anemia

for longer life of premature retics

Internal Medicine (8 decks)

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