H. Pylori

Question 1

Which virulence factor that cause the inflammatory response of the gastric linings?

Answer 1

Cag, cytotoxin proteins

Question 2

Which virulence factor that cause the perforation?

Answer 2

The VacA which cause the erosin of the stomach wall and eventually perforation

Question 3

Which part of h.pylori help in its movement& mention its role?

Answer 3

Flagella, (lopopharphocius), (2_6) at one side, helps the h pylori in swimming into less acidic compartment to cause infection

Question 4

An enzyme, that produce ammonia and has major role in pathogenesis, mention it and it’s tests?

Answer 4

UREASE, which use urea + h2o?+ O2 to produce Co2& amonia & hco3 to neurilize the acidic environment at stomach
Can be detected at 2 tests,
1. UREASE + (biochemical test)
2. Using rapid test ( breath test after ingesting urea by measuring the co2 level)

Question 5

Is h pylori a catalase (+)?

If yes, mention its role

Answer 5

H pylori is catalase (+) and it’s function beside the superoxide dismutase is to inhibit or prevent phagocytosis.

Question 6

Mention the biochemical tests of h pylro?

Then the first test should be done?

Answer 6

Catalase (+)
Oxidase)(+)
UREASE (+)
The first test is endoscopy and biopsy, which histologically should shows inflammatory cella