H E M A Flashcards
1
Q
- In patients with infectious mononucleosis,
which blood cells are infected by the
causative agent?
A. Monocytes
B. T lymphocytes
C. B lymphocytes
D. Histiocytes
A
C. B lymphocytes
2
Q
- Which of the following statements about
hairy cell leukemia is true?
A. It is an acute disease, primarily
affecting young adults.
B. Splenomegaly is an unusual finding.
C. Hairy cells contain tartrate-resistant
acid phosphatase.
D. Hairy cells are abnormal T lymphocytes
A
C. Hairy cells contain tartrate-resistant
acid phosphatase
3
Q
- Based on the WHO classification
system, B cell ALL (FAB type L3) and
represent different
clinical presentations of the same
disease entity.
A. Burkitt lymphoma
B. Hodgkin lymphoma
C. Mycosis fungoides
D. Small lymphocytic lymphoma
A
A. Burkitt lymphoma
4
Q
- The presence of both immature neutrophils
and nucleated erythrocytes in the peripheral blood is most accurately called a
A. Neutrophilic left shift
B. Regenerative left shift
C. Neutrophilic leukemoid reaction
D. Leukoerythroblastic reaction
A
D. Leukoerythroblastic reaction
5
Q
- In which anomaly is a failure of granulocytes to divide beyond the band or twolobed stage observed?
A. Pelger-Huet
B. May-Hegglin
C. Alder-Reilly
D. Chediak-Higashi
A
A. Pelger-Huet
6
Q
- In which of the following are eosinophils
not increased?
A. cushing syndrome
B. Allergic disorders
C. Skin disorders
D. Parasitic infection
A
A. Cushing syndrome
7
Q
- Which of the following represents the
principal defect in chronic granulomatous
disease (CGD)?
A. Chemotactic migration
B. Phagocytosis
C. Lysosomal formation and function
D. Oxidative respiratory burst
A
D. Oxidative respiratory burst
8
Q
- The blood shown in Color Plate 11 * is from
a leukemia patient following treatment.
These findings are most suggestive of
therapy with
A. Corticosteroids (e.g., prednisone)
B. A folate antagonist (e.g., methotrexate)
C. Recombinant erythropoietin
D. Chloramphenicol
A
B. A folate antagonist (e.g., methotrexate)
9
Q
- A patient with normal hemoglobin and
WBC count values, a persistently elevated
platelet count (over 1000 X 109/L),
increased marrow megakaryocytes, and a
history of frequent bleeding and clotting
episodes most likely has
A. Polycythemia vera
B. Chronic myelofibrosis
C. Essential thrombocythemia
D. Chronic myelogenous leukemia
A
C. Essential thrombocythemia
10
Q
- An adult patient with massive
splenomegaly has mild anemia, a slightly
elevated WBC count, and an LAP score of 170. The blood smear shows teardrop
erythrocytes and leukoerythroblastosis.
These findings are most consistent with
A. Chronic myelogenous leukemia
B. Idiopathic myelofibrosis
C. Primary polycythemia
D. Primary thrombocythemia
A
B. Idiopathic myelofibrosis
11
Q
- Which of the following infections does not
reveal a blood picture as seen in Color
Plate 12B?
A. Epstein-Barr virus (EBV)
B. Bordetellapertussis (whooping cough)
C. Cytomegalovirus (CMV)
D. Toxoplasma gondii (toxoplasmosis)
A
B. Bordetellapertussis (whooping cough)
12
Q
- The most common type of chronic
lymphocytic leukemia (CLL) in the
United States involves the
A. Bcell
B. NKcell
C. Tcell
D. Plasma cell
A
A. B cell
13
Q
- Which of the following are characteristic
findings in Waldenstrom disease?
A. Increased IgA and
hepatosplenomegaly
B. Increased IgE and renal failure
C. Increased IgG and hypercalcemia
D. Increased IgM and blood hyperviscosity
A
D. Increased IgM and blood hyperviscosity
14
Q
- Which of the following would not cause a
total WBC count of 62.2 X 109/L (62.2 X
103/jjLL) and the blood findings seen in
Color Plate 13B?
A. Treatment with myeloid growth factors
B. Gram-negative septicemia
C. Human immunodeficiency virus (HIV)
D. Systemic fungal infection
A
C. Human immunodeficiency virus (HIV)
15
Q
- The peripheral blood shown in Color Plate
14B is from a 69-year-old female. Her
WBC count was 83.0 X 109 cells/L (83.0 X
103/(xL) and her platelet count was
normal. Based on the cell morphology and
this information, what is the most likely
diagnosis?
A. Acute lymphoblastic leukemia
B. Chronic lymphocytic leukemia
C. Waldenstrom macroglobulinemia
D. Viral infection
A
B. Chronic lymphocytic leukemia
16
Q
- In which of the following is progression to
acute leukemia least likely?
A. Chronic myelogenous leukemia (CML)
B. Refractory anemia with excess blasts
(RAEB)
C. Refractory anemia with ringed
sideroblasts (RARS)
D. Chronic lymphocytic leukemia (CLL)
A
D. Chronic lymphocytic leukemia (CLL)
17
Q
- A Gaucher cell is best described as a
macrophage with
A. “Wrinkled” cytoplasm due to an
accumulation of glucocerebroside
B. “Foamy” cytoplasm filled with
unmetabolized sphingomyelin
C. Pronounced vacuolization and
deposits of cholesterol
D. Abundant cytoplasm containing
storage iron and cellular remnants
A
A. “Wrinkled” cytoplasm due to an
accumulation of glucocerebroside
18
Q
- Which of the following suggests a
diagnosis of Hodgkin disease rather than
other lymphoproliferative disorders?
A. Presence of a monoclonal population
of large lymphoid cells
B. Predominance of immature B cells
with irregular nuclear clefts
C. Circulating T cells with a convoluted,
cerebriform nucleus
D. Presence of giant binucleated Reed-Sternberg cells with prominent
nucleoli
A
D. Presence of giant binucleated Reed-Sternberg cells with prominent
nucleoli
19
Q
- In a patient with fever of unknown origin,
which of the following findings is not
consistent with an inflammatory process?
A. Increased C-reactive protein
B. Increased albumin level
C. Increased fibrinogen level
D. Increased erythrocyte sedimentation
rate
A
B. Increased albumin level
20
Q
- The presence of the chromosomal
abnormality t(15;17) and a high incidence
of disseminated intravascular coagulation
(DIG) is diagnostic of
A. Acute myeloblastic leukemia without
maturation (FAB type Ml)
B. Acute myeloblastic leukemia with
maturation (FAB type M2)
C. Acute promyelocytic leukemia (FAB
type M3)
D. Acute myelomonocytic leukemia
(FAB type M4)
A
C. Acute promyelocytic leukemia (FAB
type M3)