Gynecology Flashcards
Regulation by gonadal sex of the differentiation of the genital apparatus
Phenotypic or genital sex
Established by genetic inheritance at the moment of fertilization
Chromosomal sex
Establishment of gender role, role gender identity or sexual orientation
Psychological sex
Single most consistent determinant of maleness
Presence of y chromosome
Responsible for sex determination
SRY gene
One of the 2 copies of x chromosome present in females is inactivated
Lyon hypothesis
Tests to determine genetic sex
Sex chromatin test, hair root test, karyotyping
Cells that secrete anti mullerian hormone
Sertoli cells
Enlarges to become testis
Embryonic medulla
Proliferates to become the ovaries
Embryonic cortex
Mesonephric dcg
Wolffian ducts
Paramesonephric ducts
Mullerian ducts
Responsible for differentiation of wolffian ducts
Testosterone
Induces dissolution of mullerian ducts
MIF
Forms the testis
Medulla
Forms the ovaries
Cortex
Dubbed as gay gene
Xq28 of X chromosome
Part of brain larger in homosexual males
Suprachiasmatic
47 xxy
Klinefelter
Most common gynecologic problem in the prepubertal female
Vulvovaginitis
Translucent vertical line at the midline
Adhesive vulvitis
Management for adhesive vulvitis
Topical estrogen cream, BID for 3 weeks
Figure of 8 or hour glass; parchment like appearance of skin
Lichen sclerosus
Mgmt for lichen sclerosus
Sitz bath, avoid trauma; CLOBETASOL
Precocious puberty is defined by the onset of secondary sexual characteristics at what age
Before 8 in girls and 9 in boys
Managment for incomplete isosexual precocious puberty
Conservative management
Premature thelarche is associated with
Extremely low birthweights
Pseudo precocious puberty is due to
Granulosa cell tumor, mc cune albright syndrome
Tx for idiopathic precocious puberty
GnRH
Management for McCune albright syndrome
Aromatase inhibitor
3ps of mc cune albright
Precious puberty, pigmentation, polyostotic fibrous dysplasia (due to somatic mutation of neural crest cells)
Most useful diagnostic tool for premenstrual syndrome
Symtpom diary
What are the indications for endometrial biopsy for AUB
> 35yrs old, obesity, HPN, DM
Ovulatory DUB is due to what
Prostaglandin and fibrinolytic system
Medical managment for DUB
CEE 10mg/day in 4 divided doses;
Tx of choice for anovulatory DUB
Progestin
Androgenic steroid used for DUB
Danazol 200-400mg/day
Inhibits ovarian steroid production
Leuprolide- GnRH agonist
Definitive management for DUB
Hysterectomy
Primary dysmenorrhea is due to increased levels of
Protaglandin F2a
First line for primary dysme
NSAID
Isolated gonadotropin deficiency associated with anosmia
Kallman syndrome
Management for Turner syndrome
Estrogen therapy; cyclic progesterone- endometrial hyperplasia
Failure of ovaries to respond to FSH and LH secondary to receptor defect
Savage syndrome
Cessation of ovarian function in patients <40 yo
Premature ovarian failure
Management for mayer rokitansky kuster hauser syndrome
Neovagina creation
Management for androgen insensitivity
Gonad removal at 18yo; neovagina creation
Incision for imperforate hymen
Cruciate incision
Hematocolpos
Transvaginal septum
Hirsutism, amenorhea, obesity
Stein leventhal syndrome (PCOS)
Pituitary cell destruction as a result of a hypotensive episode during pregnancy
Sheehan’s syndrome
Pituitary cell destruction unrelated to pregnancy
Simmond’s disease
Management for premature ovarian failure
Irradiation, chemotherapy, autoimmunity
Intrauterine adhesions due to curettage
Asherman syndrome
Anovulation can be caused by
Hypothyroidism and prolactinoma
Menopause characterisitcs
51 yo; 12 mos after last; 3 mos with elevated FSH and LH
Menopause is earlier by how many yrs in smokers
2
Coverts androstenedione to estrone
Aromatas
Pathognomonic sign of menopause
Hot flushes/ flashes
Mgmt for hot flushes
Estrogen
Most accurate method to measure bone density
Dual energy xray DEXA
Risks regarding ERT
Heart, breast, stroke
Duration of ERT
6-12 mos, not >4 yrs
Prevents endometrial hyperplasia
Progrsin
Selective receptor modulator
Raloxifene
Herniation of the Pouch of Douglas
Enterovele
Grade: cervix descends halfway to the introitus
I
Grade: cervix descends to the introitus
II
Grade: cervix extends outside introitus
III
Grade: providential
IV
Pelvic strengthening exercise:
Keel’s maneuver
Endopelvic fascial reinforcement
Kelly placation
Obliteretion of vaginal canal
Colpocleisis/ effort procedure
Urethrovesicular suspension via abdominal apporach
Burch/ marshallarchetti krantz procedure
Elevation of bladder neck and urethra via vaginal and abdominal approaches
Sling procedure
Mgmt for rectocele
Posterior repair
Mgmt enterocele
Moschvitz repair
Mgmt for PCOS
OCP
Mgmt for late onset congenital adrenal hyperplasia
Glucocorticoid
Management for hair follicle and androgen sensitivity
Spironolactone
Double cervix, double vagina
Bicollis
Mucous retention cyst of endocervical columnar cells occuring when a cleft has been covered by squamous metaplasia
Nabothian cyst
Most common cervical cyst
Nanothiam cust
Cervical polyp
Most common lesion of the cervix
HPV types related with cervical CA
16,18,31,33
Mainstay tx for menopause
Estrogen replacement therapy
Example of a selective receptor modulator
Raloxifen
Pelvic strengthening exercise
Keel’s maneuver
Drugs for ovulation induction
Clomiphene citrate, metformin, hMG, GnRH
75% of ovarian masses in women
Functional cyst
Most common cause of complex adnexal mass
Benign cystic teratoma
Most common cause of a pelvic mass
Pregnancy
HONEYCOMB, straw colored fluid, multicystic, bilateral
Theca lutein cyst
Functional cysts include
Follicular, corpus luteum, theca lutein
Rpt ultrasound for follicular cyst and corpus luteum cyst are done when?
6-8 weeks
Management for premenaechal cyst >2cm
Ex lap
Most frequent ovarian epithelial tumor
Serous cystadenoma
Resembles cells of endocervix or intestinal epithelium
Mucinous cystadenoma
Transitional tumor: coffee bean appearing nucleus
Brenner tumor
Most common neoplasm in prupubertal female
Benign cystic teratoma
Most common benign solid tumor of the ovary
Fibroma
Ovarian fibroma, ascites, hydothorax
Meig’s syndrome
Most common cause of gynecological cancer death
Malignant ovarian tumor
Gene associated with increased risk for ovarian CA
BRCA 1 gene
Most common ovarian carcinoma
Epithelial
Most frequent ovarian eptihelial tumor
Serous
Epithelial cells filled with mucin
Mucinous tumors
Hobnail cells
Clear cell
Resembles transitional cells of urinary bladder
Brenner
Epithelial cells resembling endometrium
Endometrioid