Gynecologic malignancy - endometrial Flashcards
risk factors for disease development
prevention and screening methods
clinical features
principles of management
objectives
what is the most common gynecologic malignancy?
Endometrial cancer
Risk factors for endometrial cancer
- obesity
- OCPs, exercise, diet
- Unbalanced HRT
what are the warning symptoms for endometrial cancer?
- post-menopausal bleeding (15% chance)
- irregular bleeding
- bloating, pain, bowel symptoms
what is the test of choice for women with irregular vaginal bleeding
- endometrial biopsy
NOT ULTRASOUND
Type 1 endometrial cancer is
Endometrioid carcinoma
- high gland to stroma ratio
what is the prognostic factor in endometrioid carcinoma
Grade
Higher grade - More solid areas -less glands, less differentiated
Do the variants of endometrioid ca have prognostic significance?
NO
Endometrioid cancer is dependent on
Estrogen
In endometrioid ca, complex hyperplasia with atypia results in
50% risk of concurrent cancer or progression
Type 2 endometrial cancers are
- Serous papillary carcinomas
- clear cell carcinoma
Classic appearance of women with Type 1 vs Type 2 endometrial cancers
Type 1 - obese, PCOS
Type 2 - Old, thin, not estrogen dependent
Which type of endometrial cancer is more aggressive?
Type 2
is there a grading system for Type 2 carcinomas ?
NO - ALL HIGH grade
-
Precursor lesions for
1) endometrioid carcinoma
2) serous carcinoma
3) clear cell ca
1) Hyperplasia
2) Endometrial intrapithelial carcinoma
3) NO precurosor identified
