Gyne Onc Flashcards
Most common histologic types cx ca
69% squamous cell
25% adenocarcinoma
Mean age cervical cx
51
Risk factors cx ca
Early onset sexual activity Multiple sexual partners High risk sexual partner Hx of STIs Immunosupp Hx of VIN or VAIN
Which two HPV viruses ae responsible for most of the cx ca?
16
(50% SCC cx, 36% adenocarcinoma)
18
(13% SCC and 37% adenocarcinoma)
Which HPV oncogenes are responsible for inactivating human tumor suppressor genes?
E6-e7
How common are distant mets in cx ca?
Rare (0.5-1%)
What elements are essential for a good screening test?
Used to ID asx ppl in an at risk population
Condition screened for must have significant burden and incidence
High sensitivity and specificity
Tx exists
Early intervention improves outcomes
Screening test is acceptable to population
When is reflex HPV typing useful?
Age >30 and ASCUS
Should not be used if <age 30 or Pap smear worse than ASCUS
Which viral particle is used in the HPV vaccine?
L1 protein
Pap smears - what type of prevention is this?
Secondary prevention
What potential nn complication can occur from nn Hpv infection?
Recurrent respiratory papillomatosis
Risk <1%
