Gyne activity questions 5a-6 Flashcards

1
Q

What is the ultrasound appearance of PCO?

A
  • bilaterally enlarged ovaries (>10mL)
  • containing multiple small, 2- to 9-mm follicles (at least 20)
  • increased stromal echogenicity
  • Ovaries are a rounded shape
  • follicles usually located peripherally (“string of pearls”)
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2
Q

What is the classic appearance of a haemorrhagic cyst?

A
  • round
  • heterogenous
  • well defined
  • posterior enhancement
  • May occur in all types of functional cysts
  • Most frequently seen in corpus luteal cysts
  • often accompanied by acute onset of pain
  • variable in appearance due to the nature of blood
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3
Q

What is the classic appearance of an acute haemorrhagic cyst?

A

o usually hyperechoic and may mimic a solid mass
o smooth posterior wall
o shows posterior acoustic enhancement indicating the cystic nature of the lesion.
o Diffuse low-level internal echoes may be appreciated
o although this appearance is more frequently seen in endometriomas

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4
Q

What is the appearance of a haemorrhagic cyst as it haemolyzes?

A

o reticular-type pattern is demonstrated internally
o intertwining linear internal echoes representing fibrin strands
o should not be confused with septations, which are thicker.

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5
Q

What is the appearance of a haemorrhagic cyst as it retracts?

A
  • concave outer margin with angularity
  • compared with a solid mural nodule, which will have a convex outer margin.
  • Color Doppler ultrasound will show no flow within the clot
  • will demonstrate peripheral vascularity within the cyst wall.
  • Care should be taken when assessing for flow in hemorrhagic cysts, because a clot can move and show color without true vascularity.
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6
Q

What questions should you ask yourself when scanning a pelvic mass?

A
  • What neoplasms can I expect at this age? (An adnexal cystic structure may very well look like a functional cyst, but if your patient is 75 years old, it is very unlikely to be a functional cyst!)
  • Which ones are the most common?
  • Do any of the symptoms point in a certain direction? (Think of the patient with sudden onset dyspareunia. She had the diagnosis of hemorrhagic corpus luteum written all over her clinical history!)
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7
Q

Women who have ovarian carcinoma most commonly present with which of the following symptoms?

Select one:

a. Vaginal bleeding and anorexia
b. Weight loss and dyspareunia
c. Nausea and vaginal discharge
d. Constipation and frequent urination
e. Abdominal distension and pain

A

(e) Abdominal distension and pain
- 50 percent of women who have ovarian cancer present with abdominal distension
- 50 percent present with abdominal pain.
- Gastrointestinal symptoms, which occur in about 20 percent of affected women, are often secondary to the development of ascites.
- Urinary tract symptoms, caused by the pressure exerted by a rapidly growing mass 15 percent
- and abnormal vaginal bleeding are the initial symptoms of ovarian cancer in 15 percent of affected women.

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8
Q

The following statements about surface epithelial-stromal tumours are true except:
Select one:
a. They arise from the surface epithelium that covers the ovary and the underlying ovarian stroma.
b. There are five categories based on epithelial differentiation: serous, mucinous, endometroid, clear cell and transitional cell.
c. They are almost always malignant.
d. They are the most common ovarian neoplasm.
e. They account for 80-90 percent of all ovarian malignancies.

A

C
They are almost always malignant.

(they are not)

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9
Q

Serous carcinoma of the ovary can be characterised by all the following statements except:
Select one:
a. It is the most common epithelial carcinoma of the ovary.
b. It is bilateral in approximately half of affected women.
c. They most frequently occur in perimenopausal and postmenopausal women.
d. There is frequently ascites.
e. It is frequently associated with pelvic endometriosis.

A

(Serous carcinoma is not associated with endometriosis)

The correct answer is E: It is frequently associated with pelvic endometriosis.

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10
Q

True statements about mucinous tumours of the ovary include all the following except:
Select one:
a. They are usually benign.
b. They tend to be bilateral.
c. The tumour can grow to enormous proportions.
d. Rupture of the capsule may lead to pseudomyxoma peritonei.
e. They are the second most common ovarian epithelial tumour.

A

(Mucinous tumours are less frequently bilateral than their serous counterparts)

The correct answer is B: They tend to be bilateral.

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11
Q
Germ cell tumours include all the following except:
Select one:
a. Dysgerminoma
b. Granulosa cell tumour
c. Embryonal carcinoma
d. Teratoma
e. Endodermal sinus tumour
A

The correct answer is B: Granulosa cell tumour

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12
Q

True statements about ovarian neoplasms in children include all the following except:
Select one:
a. Ninety percent are malignant.
b. They are most often of germ cell origin.
c. Epithelial tumours are rare in prepubertal girls.
d. Epithelial tumours in prepubertal girls are benign in 90 percent of cases.
e. Tumours of germ cell origin are frequently malignant.

A

The correct answer is A: Ninety percent are malignant.

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13
Q

Endodermal sinus tumours are characterised by all the following statements except:
Select one:
a. They are rare.
b. They are malignant and have a poor prognosis.
c. They secrete alpha-fetoprotein (AFP).
d. They are diagnosed at the median age of 19 years.
e. They secrete hCG.

A

Epithelial tumours of the ovary, which are rare in prepubertal girls, are benign in approximately 90 percent of all cases.

The correct answer is E: They secrete hCG.

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14
Q

Which of the following statements regarding cystic teratomas is UNTRUE?
Select one:
a. They account for 15-20 percent of all ovarian neoplasms.
b. 10-15 percent are bilateral.
c. They are virtually always benign but they can undergo malignant degeneration producing a squamous cell carcinoma.
d. They primarily occur in postmenopausal women.
e. They are almost always asymptomatic.
f. They usually contain hair, sebum and fat.
g. They are also referred to as ‘dermoid cyst’.

A

The correct answer is D: They primarily occur in postmenopausal women.

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15
Q

select the description with which it is most likely to be associated.

Cystic teratoma

A. Frequently associated with virilisation.
B. Can be associated with endometrial carcinoma.
C. Has a low malignancy potential and tends to recur more than five years following the original diagnosis.
D. Primary tumour is from gastric or colonic origin.
E. Most common ovarian neoplasm in the reproductive age group.
F. Large number of signet ring adenocarcinoma cells.
G. Most common ovarian neoplasm in women older than 40.

A

(E)

Germ cell tumours/Cystic Teratomas are the most common tumours in children and young women. Ninety-five percent of germ cell tumours are benign cystic teratomas.

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16
Q

select the description with which it is most likely to be associated.

Sertoli-Leydig cell tumour

A. Frequently associated with virilisation.
B. Can be associated with endometrial carcinoma.
C. Has a low malignancy potential and tends to recur more than five years following the original diagnosis.
D. Primary tumour is from gastric or colonic origin.
E. Most common ovarian neoplasm in the reproductive age group.
F. Large number of signet ring adenocarcinoma cells.
G. Most common ovarian neoplasm in women older than 40.

A

(A)

Sertoli Leydig Cell tumours, which represent less than one percent of ovarian tumours, may produce symptoms of virilisation.

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17
Q

select the description with which it is most likely to be associated.

Granulosa cell tumour

A. Frequently associated with virilisation.
B. Can be associated with endometrial carcinoma.
C. Has a low malignancy potential and tends to recur more than five years following the original diagnosis.
D. Primary tumour is from gastric or colonic origin.
E. Most common ovarian neoplasm in the reproductive age group.
F. Large number of signet ring adenocarcinoma cells.
G. Most common ovarian neoplasm in women older than 40.

A

(B, C)

Granulosa and theca cell tumours often are associated with excessive oestrogen production, which may cause precocious puberty, postmenopausal bleeding or menorrhagia. These tumours are associated with endometrial carcinoma in 15 percent of cases. Because these tumours are quite friable, affected women frequently present with symptoms caused by tumour rupture or intraperitoneal bleeding. They are low-grade malignancies that tend to recur more than five years after the initial diagnosis.

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18
Q

select the description with which it is most likely to be associated.

(d) Krukenberg’s tumour

A. Frequently associated with virilisation.
B. Can be associated with endometrial carcinoma.
C. Has a low malignancy potential and tends to recur more than five years following the original diagnosis.
D. Primary tumour is from gastric or colonic origin.
E. Most common ovarian neoplasm in the reproductive age group.
F. Large number of signet ring adenocarcinoma cells.
G. Most common ovarian neoplasm in women older than 40.

A

(D, F)

Krukenberg’s tumours are typically bilateral solid masses of the ovary that nearly always represent metastasis from another organ usually the stomach or colon. They typically contain ‘signet-ring’ cells.

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19
Q

select the description with which it is most likely to be associated.

(e) Serous tumour

A. Frequently associated with virilisation.
B. Can be associated with endometrial carcinoma.
C. Has a low malignancy potential and tends to recur more than five years following the original diagnosis.
D. Primary tumour is from gastric or colonic origin.
E. Most common ovarian neoplasm in the reproductive age group.
F. Large number of signet ring adenocarcinoma cells.
G. Most common ovarian neoplasm in women older than 40.

A

(G)

Serous tumours are the most common ovarian neoplasm and they occur predominantly in the older than 40 group.

20
Q

What is the appropriate age group for:

(c) Granulosa cell tumour

A

B. Most commonly found in women older than 40.

21
Q

What is the appropriate age group for:

(b) Metastatic tumours

A

B. Most commonly found in women older than 40.

22
Q

What is the appropriate age group for:

(e) Endometroid tumour

A

B. Most commonly found in women older than 40.

23
Q

What is the appropriate age group for:

(d) Cystic teratoma

A

A. Most commonly found in children and young women.

24
Q

What is the appropriate age group for:

(g) Clear cell carcinoma

A

B. Most commonly found in women older than 40.

25
Q

What is the appropriate age group for:

(h) Thecoma and fibroma

A

B. Most commonly found in women older than 40.

26
Q

What is the appropriate age group for:

(i) Dysgerminoma

A

A. Most commonly found in children and young women.

27
Q

What is the appropriate age group for:

(j) Sertoli-Leydig cell tumour

A

A. Most commonly found in children and young women.

28
Q

What is the appropriate age group for:

(k) Yolk sac tumour

A

A. Most commonly found in children and young women.

29
Q

What is the appropriate age group for:

(j) Sertoli-Leydig cell tumour

A

A. Most commonly found in children and young women.

30
Q

What is the appropriate age group for:

(m) Mucinous cystadenoma

A

B. Most commonly found in women older than 40.

31
Q

What is the appropriate age group for:

(n) Brenner tumour

A

B. Most commonly found in women older than 40.

32
Q

What are the usually benign ovarian tumours. List them in each group in order of most common occurrence.

(a) Mucinous tumour
(b) Granulosa cell tumour
(c) Endometroid tumour
(d) Cystic teratoma
(e) Clear cell tumour
(f) Serous cystadenocarcinoma
(g) Brenner tumour
(h) Dysgerminoma
(i) Sertoli-Leydig cell tumour

A

a) cystic teratomas 25%
d) mucinous cystadenomas 20%
g) Brenner Tumours 1-2%
i) Sertoli Leydig Cell tumours <1%

33
Q

What are the usually malignant ovarian tumours. List them in each group in order of most common occurrence.

(a) Mucinous tumour
(b) Granulosa cell tumour
(c) Endometroid tumour
(d) Cystic teratoma
(e) Clear cell tumour
(f) Serous cystadenocarcinoma
(g) Brenner tumour
(h) Dysgerminoma
(i) Sertoli-Leydig cell tumour

A

f) serous cystadenocarcinoma 40-50%
c) endometrioid tumour 20-25%
e) Clear cell tumour 6%
h) dysgerminoma <6%
b) granulosa cell tumours

34
Q

What are the usually malignant ovarian tumours. List them in each group in order of most common occurrence.

(a) Mucinous tumour
(b) Granulosa cell tumour
(c) Endometroid tumour
(d) Cystic teratoma
(e) Clear cell tumour
(f) Serous cystadenocarcinoma
(g) Brenner tumour
(h) Dysgerminoma
(i) Sertoli-Leydig cell tumour

A

f) serous cystadenocarcinoma 40-50%
c) endometrioid tumour 20-25%
e) Clear cell tumour 6%
h) dysgerminoma <6%
b) granulosa cell tumours

35
Q

What does a small amount of complex fluid in the endometrium point to?

A

It is a non specific finding

36
Q

What does a small amount of complex fluid in the endometrium point to?

A

It is a non specific finding

37
Q

which pathology with an impact on implantation can you diagnose with an ultrasound examination?

A
Submucosal fibroids
Polyps
Ashermans syndrome
Congenital abnormalities
Hydrosalpinx
38
Q

How do submucosal fibroids effect implantation?

A

· increases the risk of infertility and pregnancy loss.
· fibroids distort the uterine cavity and make it more difficult for pregnancy to attach itself

39
Q

How do polyps effect implantation?

A
  • location of the polyps could be preventing the embryo from implanting in the uterus
  • can block the cervical canal and even prevent sperm from fertilizing the egg
40
Q

How does ashermans syndrome effect implantation?

A

• the combination of synechiae (endometrial ahesions) that lead to menstrual dysfunction or infertility
• acquired condition
• Makes the walls of the uterus and cervix stick together
Intrauterine adhesions result secondary to trauma to the basal layer of the endometrium
may be from a previous pregnancy, dilation and curettage, surgery, or infection

41
Q

Which congenital abnormalities effect pregnancy and how?

A

• Uterine septum (important diagnosis as can be resected with good outcome)
i. Septate uterus is the most common anomaly associated with subfertility, preterm labour, reproductive failure (67%), affecting ~15% of women with recurrent pregnancy loss
• Unicornate uterus – second worst obstetric outcome)
i. Spontaneous abortion rates are reported to range from 41-62%. Reported premature birth rates range from 10-20%. Fetal survival rate is ~40%
• Bicornate uterus does not effect implantation however
i. common symptomatic presentation is with early pregnancy loss and cervical incompetence.
ii. Infertility is not usually a problem with this type of malformation because implantation of the embryo is not impaired.

42
Q

How does hydrosalpinx effect implantation?

A
  • Pregnancy rates are reduced by half and the rates of spontaneous abortion are more than doubled according to the compiled data.
  • The hydrosalpingeal fluid most likely leaks into the uterus.
  • This fluid may flush embryos back out after embryo transfer or it may be toxic for the embryo.
  • So even in IVF patients, who theoretically don’t need good tubes, a thorough assessment of the tubes is necessary, because a hydrosalpinx may still be the reason that they don’t fall pregnant.
43
Q

What is OHSS?

A

Ovarian hyperstimulation is a frequent iatrogenic condition, most commonly seen after stimulation with recombinant FSH. It is characterised by weight gain, cystic ovarian enlargement, ascites and pleural effusions.

44
Q

How do you assess OHSS on ultrasound?

A

To assess the severity of the syndrome, it is useful for the clinician if ultrasound answers the following questions by checking not only the size of the ovaries but also the presence or absence of ascites and/or pleural effusions:
• What are the size of the ovaries?
• How big are the fluid pockets in the pelvis? (Is there only fluid in the pouch of Douglas? Also, fluid in the anterior pouch? Is the uterus ‘swimming’ in fluid?)
• Is there fluid in the paracolic gutters?
• Is there fluid in the kidney spaces?
• Is there fluid above the diaphragm, in the pleural spaces?

45
Q

A 33-year-old patient is pregnant after IVF. At six weeks gestation she was complaining of discomfort on the right side. A normal singleton intrauterine pregnancy was visualised on ultrasound. Heart activity was present. The patient was reassured. The discomfort was thought to be a sequel of the egg collection. Four days later the patient is admitted to emergency with increasing pain on the right side. The emergency doctor requests another ultrasound examination. Describe your thought process.

A
  • Exclusion of ectopic pregnancy in a general population is often limited to demonstration of a normal intrauterine pregnancy.
  • Despite the fact that you should always check the adnexal regions carefully, it is very likely that an intrauterine pregnancy in a general population excludes an ectopic pregnancy.
  • The incidence of heterotopic pregnancy is only around 1/25000.
  • in an IVF population an incidence as high as 1/100 has been quoted.
  • A very careful inspection of the adnexal regions is always mandatory.
  • If you don’t look actively for a heterotopic pregnancy, it is very easy to miss it.
  • If a patient is complaining of increasing pain, careful follow-up should be organised until one can confidently say that there is no heterotopic pregnancy.