Gynaeoncology Flashcards
Which ovarian tumour has transitional epithelium from Wolffian remnants?
Brenner tumour
Which ovarian tumour has no stromal invasion?
Borderline serous
Which ovarian tumour is Mullerian in origin with a poor prognosis?
Clear cell
Which ovarian tumour is associated with Meig’s syndrome?
Fibroma, thecoma
Which ovarian tumour is associated with schiller-duval bodies
Endodermal
What ovarian tumour is associated with Inhibin B
Granulosa cell
What are the side effects of
Cyclophosphamide
Alkylating agent
Haemorrhagic cystitis - as acrolein excreted in the urine
Alopecia
What are the side effects of
Paclitaxel
binds to microtubules
neutropenia, arrhythmias, sensory peripheral neuropathy, alopecia, hypersensitivity
What are the side effects of
Vincristine
binds to tubulin
neurotoxicity - parasthesia, motor weakness, CN palsy
myelosuppression
What are the side effects of
Cisplatin
Nephrotoxic
Peripheral neuropathy
Middle ear hearing loss and tinnitis
What are the side effects of
Methotrexate
mucositis nausea, vomiting photosensitivity nephrotoxicity hepatotoxicity
Tell me about..
Mucinous tumours - cystadenoma
Cystadenoma - multilocular
Rupture may cause pseudomyxoma peritonei and SBO
Tell me about..
Mucinous tumours - cystadenocarcinoma
Usually solid
Can be associated with appendicular cancer
Inc CEA and CA125
Tell me about..
Clear cell carcinoma
Mullerian origin
Poor prognosis
10% are bilateral
15% primary in the uterus
Tell me about..
Brenner tumours
Transitional epithelium from Wolffian remnants
Fibrous elements
Usually benign (99%)
Tell me about..
Borderline tumours
Low malignant potential No stromal invasion May have extra ovarian spread in 20% serous - 50% bilateral mucinous - 5% bilateral
Tell me about..
Endometrioid carcinoma
May be secondary from endometrial cancer
Can arise in endometriosis
Tell me about..
Granulosa cell tumours
Solid 75% endocrine function Usually over 60 years old, can be prepubescent PMB/precocious puberty Juvenile - 5% malignant and aggressive
Tell me about..
Androblastoma
Sertoli - most common and usually benign
70% oestrogen, 20% androgen, 10% no hormones
Tell me about..
Germ cell tumours
2-3% malignant
30% if woman aged less than 20
Tell me about..
Dysgerminoma
10-15% bilateral
Not associated with hirsutism
Secretes: LDH, pALP, b-hCG(30%)
Histology: “lymphoid infiltration of the stroma”
Tell me about..
Embryonic tumours
Dermoids - usually benign
1% change to malignant
If immature teratoma - often in first 2 decades of life and often malignant. unilateral. Thyroid hormones - struma ovarii or serotonin - carcinoid
Embryonal carcinoma - secretes b-hCG and AFP
Tell me about..
Yolk sac/endodermal sinus tumour
secretes AFP
presents 14-20 years
unilateral
Tell me about..
Malignant ovarian choriocarcinoma
secrete b-hCG
may present with precocious puberty
poor prognosis
