Gynaecology Flashcards
28 years old girl complaining of severe abdominal pain during her periods for the last 6 months.
What are the differential diagnosis?
- Endometriosis
- PID
- Fibroids
- IUCD
28 years old girl complaining of severe abdominal pain during periods.
What is the diagnosis?
Condition: Endometriosis
Cause: Unknown
Commonality: very common 1 in 100 women have it.
Most common site of endometriosis- walls of the uterus, ovaries, fallopian tubes, uterine ligaments, and other pelvic organs.
Clinical features:
1. Dysmenorrhea
2. Dyspareunia
3. Dyschazia
4. Menorrhagia
Signs: in DRE - nodularity and tenderness in the pouch of Douglas and uterosacral ligament
Complications:
1. Menorrhagia
2. Infertility
28 years old girl complaining of severe abdominal pain during periods.
Investigations and Management
Investigations:
1. FBE with ESR and CRP
2. UEC
3. Coagulation profiles
4. USG of the lower tummy - to rule out fibroids
5. Transvaginal USG and laparoscopy (CONFIRMATORY)
Treatment
1. Panadol for the pain
2. Refer to specialist
Medical treatment:
1. OCP - taken for 6 months
2. Progestens like Depoprovera and Mirena
3. GnRh analagues -intra-nasally or injections 3 or 6 monthly
- cannot be taken for more than six months
- induce severe postmenopausal symptoms like hot flushes, heavy, sweatings mood, swings, joint pain, muscle, pain, and osteoporosis 
- Danazol - for 3-6 months
- cannot be taken more than six months
- mail characteristics like voice change, increased hair growth
Surgical:
-If medical management fails
- infertility
- severe symptoms
1. Laparoscopy cutting away of the deposits
2. Endometrial ablation by laser or electrocautery
17 year old Maya has not started her periods yet.
What can be the probable causes?
Hypothalamic causes:
1. Eating disorders
2. Exercise related
3. Stress related
4. Chronic illnesses - long term renal or liver problems, DIABETES, severe depression)
5. Kalman’s Syndrome
Pituitary causes:
1. Hyperprolactinoma
Ovarian causes:
1. PCOS
2. POF
3. Turners syndrome
4. Chemotherapy or radiotherapy to the ovaries
Uterine causes:
1. Pregnancy
2. Mullerian Agenesis
3. Androgen Insensitivity Syndrome
Vaginal causes:
1. Imperforate hymen
2. Transverse vaginal septum
Other hormonal causes:
1. Hyper/Hypothyroidism
2. Cushing syndrome
17 years old Maya has not started her periods yet.
What investigations will you do?
Blood :
FBE with ESR and CRP
S. UEC
LFT
TFT
S. Prolactin level
LH, FSH
Oestrogen and Progesterone level
Urine: UPT
Imaging: Pelvic USG
Karyotyping : Turners and Kallman’s Syndrome
20 years old Maria presents to the GP with absence of periods for the last 6 months.
What can be the causes?
Causes of secondary amenorrhea:
- Pregnancy
- Post-pill amenorrhea
- PCOS
- POF
- HyperProlactinaemia
- Asherman syndrome
- Thyroid disorders
- Eating disorders
**9. Exercise induced amenorrhea - Stress related
A ballat dancer has not had her periods for 6 months .
What is the condition and what is its management?
Condition: Exercise Induced Amenorrhea
Cause: HPO axis dysfunction
Complications:
1. Infertility
2. Decrease in bone density, bones become brittle and break easily
3. Increased cholesterol levels
4. Premature aging
Investigations:
1. FBE
2. UEC
3. LFT
4. TFT
5. Serum prolactin
6. Vitamin D and calcium levels
7. Hormones: GnRh, LH, FSH, oestrogen and progesterone
8. Pelvic USG
Management:
1. Refer to specialist
2. Adopt healthy lifestyle:
- put on 2-3kg weight
- limit exercise to 8 hours/week
3. Refer to dietician for dietary advice
4. Prescribe, vitamin D and calcium supplements
If these are not working in six months, we can put you on OCP.
A 30 years old woman, having OCP did not have her periods follow the last two courses of pills.
- What is the diagnosis?
- Management of this condition.
- Key point in this case
Diagnosis: Post-pill amenorrhea
Management:
1. Do a UPT to rule out pregnancy
2. Periods will become normal once you discontinue the pill.
3. Prescribe another pill with a higher dose of oestrogen
OR, 4. Prescribe a triphasic pill
OR, 5. Stop OCP and try other methods of contraception
Key point and critical error:
Must do a Urine Pregnancy Test
38 years old Susan is complaining of heavy menstrual bleeding for the last 4 months.
What are the possible causes?
- Endometriosis
- Fibroids
- PID
- Ovarian tumours/cysts
- Thyroid disorders (hyperthyroidism)
- Bleeding disorders
- Blood thinners
**8. DUB
38 years old Susan is complaining of heavy menstrual bleeding for the last 4 months.
What investigations will you do?
- FBE : to see Hb and Platelet count
- If Hb is low: Iron profile
- Blood grouping and cross matching
- Coagulation profiles
- LFT
- TFT
- UEC
- Pelvic USG
- Endometrial sampling (must in women >35years to rule out malignant changes)
Management of DUB
- Refer to the specialist
Give iron tablets - Conservative - for 6 months
•Non Hormonal management:
1. Tranexamic acid
2. Mefenamic acid• Hormonal management: 1. OCP 2. Mirena 3. IUCD 4. GnRh analogue, Danazol
- Surgical:
1. Endometrial ablation
2. Hysterectomy (if family complete)
13 years old Maria has been brought by her mother due to heavy bleeding during her first period.
What can be the possible causes?
- Pubertal Menorrhagia
- Pregnancy
- Thyroid disorders
- Bleeding disorders
- Blood thinners
25 year old Isa presented with lower abdominal pain for the past one hour.
What can be the causes?
- Mittleschmerz
- Ectopic pregnancy
- PID
- Ovarian cyst
- Acute appendicitis
- Bowel obstruction
- Acute pyelonephritis
- Renal stones
Contraindications of combined OCP
Absolute contradictions:
1. DVT
2. Breast cancer
3. Active liver disease or previous cholestatic jaundice
4. Unexplained vaginal bleeding
5. Migraine
Relative contraindications:
1. HTN
2. DM
3. Severe depression
4. Very irregular periods and oligomenorrhoea
Mechanism of action of OCP
Contains two female hormones: Oestrogen and Progesterone
(That are normally present in the body and which regulate our menstrual cycle)
Mechanism of action:
1. Preventing ovulation/stopping the release of eggs from the ovaries
2. Make the cervical secretions thick so that sperm cannot enter
3. Thinning of the endometrium which prevents fertilisation
Side effects of OCP
- Nausea/vomiting and diarrhoea
- Abdominal distension or bloating
- Breast soreness - in just the first 1-2cycles
- Breakthrough bleeding/Bleeding in between periods - usually settles in 3-4 months
Major side effects (rare with low dose pills)
1. Stroke
2. DVT
3. MI
Advantages of OCP
- Periods become more regular, lighter and shorter
- Less pain during periods
- Decreased incidence of :
benign breast lumps
PID
Thyroid disorders
Endometrial and ovarian cancers
Which OCP to start with and How to take it
Start with low dose oestrogen pill
- less breakthrough bleeding
- low failure rate
Better to choose a triphasic pill
- less post-pill amenorrhoea
How to take:
From a 28pack pill
21 pills - hormonal
7 pills - sugar coated or dummy
• Start from the first day of your next period,
• 1 tablet each day and at the same time every day.
• then take the 7 sugar pills and you will get your periods
• Contraceptive efficacy comes after 7 pills.
So use condoms until that time
Must remember about OCPs
- Contraceptive efficacy takes around 7 pills to become satisfactory. So use condoms as well till then.
- OCPs do not give protection against STI. Use condoms if STI is a concern.
- If diarrhoea or vomiting occurs within 2 hours of taking the pill, then take a pill again and keep going with the rest.
Use condoms until diarrhoea and vomiting lasts. - If you go to a doctor or pharmacist for any condition, let them know that you are taking OCP because there are many medicines that interfere with it
- Follow up in 3 months to check your
-BP
- pills are working properly or not
- any problems due to which the pills need to be changed
25 year old Maria has given birth 2 weeks ago and is exclusively breastfeeding her child. She wants to know the contraceptive options available for her.
- Barrier methods : Condoms and Vaginal rings or diaphragms
- Progesterone only pills
- Depo-Provera or medroxyprogesterone acetate
- Implanon
- IUCD
Contraindicated in breast feeding mothers:
1. Combined OCPs
2. Lactational amenorrhoea - not much safe or reliable