Gynaecology Flashcards

1
Q

Definition of primary amenorrhea

A

By 13 years with no other evidence of pubertal development
By 15 years with some other signs of puberty

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2
Q

Age of puberty onset in girls

A

8-14 years

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3
Q

Age of puberty onset in boys

A

9-15 years

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4
Q

Structural causes of amenorrhoea

A

Imperforate hymen
Transverse vaginal septae
Vaginal agenesis
Absent uterus
FGM

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5
Q

Causes of secondary amenorrhoea

A

Pregnancy
Menopause
Hormonal contraception
Hypothalamic/pituitary pathology
PCOS
Ashermann’s syndrome
Thyroid pathology
Hyperprolactinaemia

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6
Q

Hormone tests for secondary Amenorrhoea

A

bHCG
FSH - high in primary ovarian failure
LH - high in PCOS
Prolactin
TFTs
Testosterone - PCOS, androgen insensitivity, congenital adrenal hyperplasia

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7
Q

Causes of menorrhagia

A

Dysfunctional uterine bleeding
Extremes of reproductive age
Fibroids
Endometriosis
PID
Copper coil
Anticoagulants
Bleeding disorders
PCOS
Connective tissue disorders

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8
Q

Management of menorrhagia

A

Tranexamic acid
Mefenamic acid
Mirena coil
COCP

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9
Q

Types of uterine fibroid

A

Intramural
Subserosal
Submucosal
Pedunculated

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10
Q

Presentation of uterine fibroids

A

Asymptomatic
Heavy menstrual bleeding
Abdominal pain, worse during menstruation
Bloating
Urinary/bowel symptoms
Deep dyspareunia
Reduced fertility

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11
Q

Management of fibroids <3cm

A

Mirena coil
Symptomatic management
COCP
Endometrial ablation
Resection during hysteroscopy

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12
Q

Management of fibroids >3cm

A

Symptomatic management
Mirena coil
Uterine artery embolisation
Myomectomy

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13
Q

Complications of uterine fibroids

A

Heavy menstrual bleeding
Reduced fertility
Miscarriage
Premature labour
Constipation
Urinary outflow obstruction
Torsion of fibroid

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14
Q

Potential aetiologies for endometriosis

A

Retrograde menstruation
Embryonic cells remaining outside the uterus
Lymphatic spread of endometrial cells

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15
Q

Presentation of endometriosis

A

Cyclical pelvic pain
Deep dyspareunia
Dysmenorrhoea
Infertility
Urinary symptoms
Bowel symptoms

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16
Q

Examination findings in endometriosis

A

Endometrial tissue visible on speculum examination
Fixed cervix
Tenderness in vagina, cervix & adnexa

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17
Q

Gold standard diagnostic investigation for endometriosis

A

Laparoscopy

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18
Q

Management of endometriosis

A

Analgesia
COCP
Medroxyprogestrone acetate injection
GnRH agonists
Laparoscopic ablation
Hysterectomy

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19
Q

Sex hormone profile in menopause

A

Oestrogen & progestrone low
LH & FSH high

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20
Q

Risks of HRT

A

Breast cancer
Endometrial cancer
VTE
Stroke & CAD

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21
Q

Contraindications for HRT

A

Undiagnosed abnormal bleeding
Endometrial hyperplasia
Breast cancer
Uncontrolled HTN
VTE
Liver disease
Active angina
Pregnancy

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22
Q

Which type of HRT for peri-menopausal women

A

Cyclical combined

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23
Q

Which type of HRT in post-menopausal women

A

Continuous combined

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24
Q

Types of ovarian cyst

A

Follicular cyst
Corpus luteum cyst
Serous cystadenoma
Mucinous cystadenoma
Endometrioma
Dermoid cyst
Sex cord-stromal tumour

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25
Q

Risk factors for ovarian malignancy

A

Increased age
Postmenopause
Early menarche
Late menopause
Nulliparity
Obesity
HRT
Smoking
BRCA1/BRCA2

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26
Q

Causes of raised CA125

A

Endometriosis
Fibroids
Adenomyosis
Pelvic infection
Liver disease
Pregnancy

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27
Q

Meig’s Syndrome triad

A

Ovarian fibroma
Pleural effusion
Ascites

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28
Q

What is Asherman’s Syndrome

A

Adhesions that form within the uterus

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29
Q

Presentation of Asherman’s Syndrome

A

Post recent dilatation & curettage, uterine surgery to endometriosis
Secondary amenorrhoea
Significantly lighter periods
Dysmenorrhoea

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30
Q

Gold standard investigation for Asherman’s syndrome

A

Hysteroscopy

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31
Q

What is cervical ectropion

A

Columnar epithelium of the endocervix extends out into the ectocervix

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32
Q

Presentation of cervical ectropion

A

Increased vaginal discharge
Vaginal bleeding
Dyspareunia
Postcoital bleeding

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33
Q

Management of cervical ectropion

A

Cautery with silver nitrate if problematic bleeding

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34
Q

What is vault prolapse

A

Occurs in women that have had a hysterectomy. The top of the vagina descends into the vagina

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35
Q

What is rectocele

A

Defect in the posterior vaginal wall that allows the rectum to prolapse forward into the vagina

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36
Q

What is cystocele

A

Defect in the anterior vaginal wall, allowing the bladder to prolapse backwards into the vagina

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37
Q

Risk factors for pelvic organ prolapse

A

Multiple vaginal deliveries
Instrumental/traumatic delivery
Advanced age
Obesity
Chronic respiratory disease
Chronic constipation

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38
Q

Presentation of pelvic organ prolapse

A

Dragging sensation in the pelvis
Feeling of something coming down into the vagina
Incontinence
Urgency
Retention
Constipation
Reduced sexual enjoyment
Altered sexual sensation
Painful intercourse

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39
Q

Grade 1 uterine prolapse

A

The lowest part is more than 1cm above the introitus

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40
Q

Grade 2 uterine prolapse

A

The lowest part is within 1cm of the introitus

41
Q

Grade 3 uterine prolapse

A

The lowest part is more than 1cm below the introitus, but not fully descended

42
Q

Grade 4 uterine prolapse

A

Full descent with eversion of the vagina

43
Q

Conservative management of pelvic organ prolapse

A

Physiotherapy
Weight loss
Reduced caffeine intake
Vaginal oestrogen cream

44
Q

Pathophysiology of urge incontinence

A

Overactivity of the detrusor muscle of the bladder

45
Q

Symptoms of urge incontinence

A

Sudden need to pass urine
Having to rush to the bathroom
Not making it to the toilet in time
Avoidance of activities that reduce bathroom access

46
Q

Symptoms of stress incontinence

A

Urinary leakage when coughing, laughing or surprised

47
Q

Risk factors for urinary incontinence

A

Increased age
Postmenopausal status
Increased BMI
Previous pregnancy
Previous vaginal delivery
Pelvic organ prolapse
Pelvic floor surgery
Multiple sclerosis
Dementia

48
Q

Investigations for urinary incontinence

A

Bladder diary
Urine dipstick
Post-void bladder scan
Urodynamic testing

49
Q

Non surgical management of stress incontinence

A

Avoid caffeine & diuretics
Avoid excessive fluid intake
Weight loss
Supervised pelvic floor exercises
Duloxetine

50
Q

Surgical management of stress incontinence

A

Tension free vaginal tape
Intramural urethral bulking
Colposuspension

51
Q

Non-surgical management of urge incontinence

A

Bladder retraining
Oxybutynin
Tolterodine
Mirabegron

52
Q

Surgical management options for urge incontinence

A

Botox injections
Percutaneous sacral nerve stimulation
Augmentation cystoplasty

53
Q

Presentation of atrophic vagintitis

A

Postmenopausal women
Itching
Dryness
Dyspareunia
Bleeding
Recurrent UTI

54
Q

Features of atrophic vaginitis on examination

A

Pale mucosa
Thin skin
Reduced skin folds
Erythema & inflammation
Dryness
Sparse pubic hair

55
Q

Management of atrophic vaginitis

A

Vaginal lubricants
Estriol cream
Estriol pessaries

56
Q

Which diseases are associated with Lichen Sclerosus

A

Type 1 diabetes
Alopecia
Hypothyroid
Vitiligo

57
Q

Presentation of lichen sclerosus

A

Itching
Soreness
Skin tightness
Painful sex
Erosions
Fissures

58
Q

Appearance of lichen sclerosus

A

Porcelain white
Shiny
Tight
Thin
Slightly raised
Papules/plaques

59
Q

Management of lichen sclerosus

A

Referral to dermatology/gynaecology
Dermovate
Emollients

60
Q

Complications of lichen sclerosus

A

Squamous cell carcinoma of the vulva
Sexual dysfunction
Narrowing of vaginal/urethral openings

61
Q

Type 1 FGM

A

Removal of part or all of the clitoris

62
Q

Type 2 FGM

A

Removal of part or all of the clitoris and labia minora

63
Q

Type 3 FGM

A

Narrowing or closing of the vaginal space

64
Q

Type 4 FGM

A

All other unnecessary procedures to the female genetalia

65
Q

Short term complications of FGM

A

Pain
Bleeding
Infection
Swelling
Retention
Urethral damage
Incontinence

66
Q

Inheritance pattern of androgen insensitivity syndrome

A

X-linked recessive

67
Q

Features of androgen insensitivity syndrome

A

Genetically male
Female phenotype
Female external genitalia & breast tissue
Abdominal/inguinal testes
Taller than average
Infertile

68
Q

Hormone test results in androgen insensitivity syndrome

A

Raised LH
Normal/raised FSH
Normal/raised testosterone
Raised oestrogen

69
Q

Management of androgen insensitivity syndrome

A

Bilateral orchidectomy
Oestrogen therapy
Vaginal dilators

70
Q

Most common subtype of cervical cancer

A

Squamous cell carcinoma

71
Q

Which types of HPV are associated with cervical cancer

A

16 & 18

72
Q

Risk factors for developing cervical cancer

A

Early sexual activity
Increased number of sexual partners
Unprotected sex
Non-engagement with cervical screening
Smoking
HIV
Increased number of full term pregnancies
Family history

73
Q

Cervical appearance consistent with cervical cancer

A

Ulceration
Inflammation
Bleeding
Visible tumour

74
Q

CIN 1?

A

Mild dysplasia, 1/3 thickness of epithelial layer
Likely to return to normal spontaneously

75
Q

CIN II?

A

Moderate dysplasia, 2/3 thickness of epithelial layer
Likely to progress to cancer if untreated

76
Q

CIN III?

A

Severe dysplasia
Very likely to progress to cancer

77
Q

Management of CIN / early stage cervical cancer

A

LLETZ
Cone biopsy

78
Q

Management of stage 1B-2A cervical cancer

A

Radical hysterectomy + lymph node removal
Chemotherapy
Radiotherapy

79
Q

Management of stage 2b - 4A cervical cancer

A

Chemotherapy
Radiotherapy

80
Q

Which strains of HPV cause genital warts

A

6 & 11

81
Q

Risk factors for endometrial cancer

A

Increased age
Early onset of menstruation
Late menopause
Oestrogen only HRT
No/few pregnancies
Obesity
PCOS
Tamoxifen
T2DM
Lynch syndrome

82
Q

Protective factors against endometrial cancer

A

COCP
Mirena coil
Increased pregnancies
Smoking

83
Q

Presentation of endometrial cancer

A

Postcoital bleeding
Intermenstrual bleeding
Heavy menstrual bleeding
Abnormal vaginal discharge
Haematuria
Anaemia
Raised platelet count

84
Q

Investigating suspected endometrial cancer

A

Transvaginal US for endometrial thickness (<4mm)
Pipelle biopsy
Hysteroscopy with endometrial biopsy

85
Q

Stages of endometrial cancer

A

1 - Confined to uterus
2 - Invades cervix
3 - Invades ovaries, fallopian tubes, vagina or lymph nodes
4 - Invades bladder, rectum or beyond pelvis

86
Q

Management for endometrial cancer

A

Total abdominal hysterectomy with bilateral salpingo-oophorectomy

87
Q

Types of ovarian cancer

A

Serous tumours
Endometrioid carcinomas
Clear cell tumours
Mucinous tumours
Undifferentiated tumours
Teratomas
Sex cord stromal tumours

88
Q

Risk factors for ovarian cancer

A

Age (peaks at 60)
BRCA1/BRCA2
Obesity
Smoking
Recurrent clomifene
Early onset of periods
Late menopause
Nulliparity

89
Q

Protective factors against ovarian cancer

A

COCP
Breast feeding
Pregnancy

90
Q

Presentation of ovarian cancer

A

Abdominal bloating
Early satiety
Loss of appetite
Pelvic pain
Urinary symptoms
Weight loss
Abdominal/pelvic mass
Ascites
Referred hip/groin pain

91
Q

Which tumour markers are relevant for ovarian cancer

A

CA125
a-FP
HCG

92
Q

Stage 1 ovarian cancer

A

Confined to the ovary

93
Q

Stage 2 ovarian cancer

A

Spread past the ovary but confined to the pelvis

94
Q

Stage 3 ovarian cancer

A

Spread past the pelvis but within the abdomen

95
Q

Stage 4 ovarian cancer

A

Distant metastases

96
Q

Most common subtype of vulval cancer

A

Squamous cell carcinoma

97
Q

Risk factors for vulval cancer

A

Advanced age
Immunosuppression
HPV
Lichen sclerosus

98
Q

Management of vulval intraepithelial neoplasia

A

Watch & wait
Wide local excision
Imiquimod cream
Laser ablation

99
Q

Presentation of vulval cancer

A

Vulval lump
Ulceration
Bleeding
Itching
Pain
Groin lymphadenopathy