Gynaecology Flashcards
Gynae
- Benign
- Oncology
Gynae
- Benign
1. Fibroids
2. Pelvic pain
3. Menstrual problems - Oncology
1. Cervical screening
2. Colposcopy
3. Postmenopausal bleeding
4. Cancers
Obstetrics
- Care indications
Obstetrics
- Care indications
- Pre-conceptual/Antenatal
- High risk pregnancy
- Labour and delivery
- Puerperium
- Emergencies
Gynae History
- Structure
Gynae History
- Structure
- Reason for attendance
- Menstrual history
- First day of LMP
- Number of days and flow
- Cycle
- Bleeding (inter/post coit)
- Menarche age
- Pain - Contraception/HRT
- Previous gynae history
- Smear and result
- Problems and treatments/operations
- (PID, STI, cysts, smear, myomectomy/hysterectomy/prolapse) - Obstetric history
- Gravidity and parity
- Pregnancy outcomes/modes
- Birth weights - Medical and surgical
- Blood transfusion/complication
- Anaesthesia/complication - Medications/allergies
- Social history
- Support
- Social services, domestic violence, MH
- Smoking/drugs/alcohol - Sexual
- STI
- Partners - FH
- Cancers
- DM, HTN, CVD, VTE
Gynaecology
- Common complaints
Gynaecology
- Common complaints
- Periods
- painful/heavy/irregular - Pain
- Pelvic/on intercourse - Urinary incontinence
- Prolapse
- Infertility/Sterilisation
- Bleeding
- Pregnancy/postmenopausal - PID/discharge
Menstrual cycle
- HPA Hormones
Menstrual cycle
- Hormones
- GnRH
- Hypothalamus - LH/FST
- Pituitary - Oestrogen/progesterone
Menstrual cycle
- Start event
Menstrual cycle
- Start event
- First day of menses
Menstrual cycle
- Phases
Menstrual cycle
- Phases
- Follicular
- proliferative - Luteal
- Secretory
Follicular phase
- Development of….
Follicular phase
- Development of….
- Dominant follicle
Luteal phase
- Development of…
Luteal phase
- Development of
- Corpus luteum
Menstrual hormone peaks
- FSH
- LH
- E2
- P
Menstrual hormone peaks
- FSH
- First day of menses (day 0)
- Ovulation (14) - LH
- Ovulation (14) - E2
- Before ovulation (before 14)
- before menses - P
- Luteal phase
Normal cycles
- Length
- Regularity
- MBL
Normal cycles
- Length
1. 24-32 - Regularity
2. Best aged 20-40y
3. Shorter pre-menopause, longer post- - MBL
- 37-43ml
- 9-14% >80ml (likely anaemic)
Menstrual blood loss
- Factors
Menstrual blood loss
- Factors
- Age - increases
- Genetics (twin-studies)
- Parity (+ve correlation)
Menstrual acronyms
- HMB
- Metro
- IMB
- PCB
- Oligo
- Amen
Menstrual acronyms
- HMB
- menorrhagia - Metrorrhagia
- irregular - IMB
- Inter-menstrual - PCB
- Post-coital - Oligomenorrhea
- Infrequent - Amenorrhoea
- Absent
DUB
- 60% is…
- Definition
DUB
- Heavy menstrual bleeding
- no recognisable pelvic pathology
- no pregnancy/bleeding disorders
- Exclusion - 60% is Primary Menorrhagia
AUB/HMB
- Pathologies
- Medical/clotting
- Other
AUB/HMB
- Pathologies
1. Fibroids
2. Adenomyosis/endometriosis
3. IUCD
4. PID
5. Polyps - Medical/clotting
1. Hypothyroid
2. Liver
3. Von Willebrand’s
4. Thrombocytopenia/ leukaemia
5. Platelets/coags - Other
1. Cancer
2. Hyperplasia
AUB
- Clinical Assessment
AUB
- Clinical Assessment
Subjective
1. Only 50% have greater than normal loss
2. Only 60% with MBL<80ml consider them heavy
Best measure
1. QoL
- Work/social/clothing/bedding/sleep
- Anaemia
HMB
- Assessment
HMB
- Assessment
- Low risk
1. <45y, No IMB, No RFs for endometrial cancer
2. History +Exam + FBC
3. First line treatment - High risk
1. >45y, IMB, Suspicious, RFs
2. Hx + Ex + FBC + USS + Hysteroscopy & Biopsy
3. First line treatment
HMB
Medical Mx
HMB Medical Mx
- Symptomatic
1. Tranexamic acid
2. mefenamic acid - Fibroids
1. GnRH analogues
2. Esmya (ulipristal acetate) - Hormonal control
1. POP
2. LARC (long-acting reversible)
eg. Mirena (prog)
3. Implant
4. Depo-Provera - Hormonal control-combined
1. COCP
HMB
- Surgical Mx
HMB Surgical Mx
- Polyps
1. Hysteroscopic removal
(MYOSURE) - Fibroids
1. Myomectomy
2. Uterine artery embolization - Family complete
1. Endometrial ablation
(NOVAURE)
2. Hysterectomy
(Lap or open)
HMB
- Emergency management
HMB
- Emergency management
- Tranexamic acid
- Norethisterone
- 5mg po dts
- up to 7 days or 3 weeks on, 1 week off - GnRH analogues
- Monthly injection
- downregulate cycle (medical menopause)
Tranexamic acid
- effects
Tranexamic acid (anti-fibrinolytic)
- effects
- Plasminogen inhibition (tPA)
- Reduces MBL by 50%
- ADRs
- Nausea, abdo cramp
- Dizziness, tinnitus
- Rash
Mefenamic acid
- Effects
Mefenamic acid
- Effects
- NSAID
- Inhibit PG production - Reduces MBL by 20-44%
- ADRs
- GI
- Dizziness/headaches
- Liver
- Asthma & Renal
Infrequent/absent periods
- Definitions
Infrequent/absent periods
Oligomenorrhea
1. Cycle is slow
- 35 days - 6 months
Amenorrhoea
1º No menarche by 16
2º Absent for 3/12 if regular
- Absent for 6/12 if oligomenorrheic
Oligomenorrhea
- Causes
Oligomenorrhea
- Causes
- Constitutional
- Anovulation
1. PCOS
2. Thyroid
3. Prolactinoma
4. CAH
Amenorrhoea
- Causes
Amenorrhoea
- Causes
- Physiological
1. Pre-pubertal
2. Pregnancy
3. Menopause
Pathological
1. Cryptomenorrhea
- Hematocolpos
- Hematometra
- Uterine/endometrial cause
- Ovarian
- Pituitary/hypothalamic
Amenorrhoea
- Primary causes
Amenorrhoea
- Primary causes
- Delayed puberty
- Imperforate hymen
- Absent vagina
- Mullerian agenesis
- Turner
- PCOS (rare primary)
- CAH
Amenorrhoea causes
- Secondary
Secondary amenorrhoea
- Pregnancy
- PCOS
- Premature menopause
- Prolactinoma
- Thyroid disease
- Cushing’s
- EDs
- Syndromes
- Asherman (scarring)
- Sheehan (bleeding)
Amenorrhoea
- FSH investigation
Amenorrhoea
- FSH investigation
- Pituitary/hypothalamus
- Low FSH - Ovary
- High FSH
Primary Amenorrhoea
- Primary Ix pathway
Primary Amenorrhoea
- Ix
- Pregnancy test
- TSH
- Prolactin
- LH/FSH
a. Low FSH
- constitutional delay, ED, exercise, stress, illness
b. High FSH
- Uterus? (Mullerian agenesis XX, androgen insensitivity XY)
- Karyotyping? (Turner Xo, Premature menopause XX)
Secondary Amenorrhoea
- Ix
Secondary Amenorrhoea
- Ix
- Pregnancy
- TSH
- Prolactin
- High FSH
- Premature menopause
- Turner mosai - Normal FSH
- PCOS
- Uterine adhesions - Low FSH
- ED, exercise, stress, illness, sheehan
PCOS
- Features
PCOS
- Features
- Hyperandrogenism
- Acne
- Hirsutism
- Obesity - Anovulation
- Oligo/amenorrhoea
- Multiple follicles on US (12+ in one or both ovaries)
and/or
- Increased ovarian volume (>10cm3)
Rotterdam criteria
- PCOS
Rotterdam criteria
- PCOS
Two or more of:
- Clinical/biochemical signs of hyperandrogenism
- Oligo/amenorrhoea
- US features
PCOS
- DDx
PCOS
- DDx
- Obesity
- Premature ovarian failure
- Thyroid
- Prolactinoma
- CAH/ Androgen tumour/ Cushing’s
PCOS
- Ix
PCOS
- Ix
- SHBG
- Sex hormone binding globulin - Total testosterone
- FAI
- Free androgen index - FSH/LH
- TFT
- Prolactin
PCOS
- General Mx
PCOS
- General Mx
- Weight loss
- Healthy lifestyle
- Glucose tolerance screening
- MH screening