Gynae cancers! Flashcards

1
Q

What is passing vaginal blood post-menopaus until proven otherwise?

A

Endometrial cancer

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2
Q

What is clinically significant about pyometra in relation to endometrial cancer?

A

It can hide occult malignancy

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3
Q

What are the symptoms associated with endometrial cancer?

A
  • Post-menopausal bleeding

* Inter-menstural bleeding

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4
Q

What are the risks associated with developing endometrial cancer?

A
  • Weight → obesity ↑↑ risk
  • Null parity
  • Late menopause
  • Unopposed exposure to oestrogen → HRT,
  • Tamoxifen
  • Combination pill
  • Smoking
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5
Q

What type of cancer is endometrial cancer?

A

Adenocarcinoma

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6
Q

What is the triple investigation for uterine/endometrial cancer?

A

• clinical Hx and examination + Transvaginal USS scan + Hysteroscopy

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7
Q

What is the best mode of imagine to stage uterine/endometrial cancer?

A

MRI

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8
Q

What is the treatment for Uterine/endometrial cancer?

A

Treatment is stage dependent.

Surgery ± chemotherapy ± radiotherapy

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9
Q

What are the diagnostic tests for uterine/endometrial cancer?

A

triple investigation → clinical Hx and examination + Transvaginal USS scan + Hysteroscopy

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10
Q

What is the first line treatment for Ovarian cancer?

A

Ultrasound

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11
Q

What cancer marker can be used to detect ovarian cancer?

A

Ca-125

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12
Q

What is the most common cause of gynecological cancer deaths?

A

ovarian cancer

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13
Q

Which genes are associated with a raised risk of contracting Ovarian cancer?

A

BRCA 1 + BRCA 2

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14
Q

What is the major problem with developing Ovarian cancer?

A

It is incredibly hard to detect unitil it at an advanced stage

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15
Q

What are the symptoms of Ovarian cancer?

A
  • Persistent bloating and vague abdominal pain
  • Feeling of pressure in the pelvic area
  • Loss of appetite
  • Weight loss
  • Lower back pain
  • Dyspareunia
  • Altered bowel habit
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16
Q

What are the risk factors for developing ovarian cancer?

A
  • Age (75% occurring in over 55’s)
  • HRT and endometriosis
  • Smoking and asbestos
  • Diabetes
  • Family Hx (7% cases positive family Hx) and BRCA1 and BRCA2 mutations
  • High BMI and being very tall
  • Previous Ca and previous radiotherapy
17
Q

What does RMI stand for in relation to cancer?

A

Risk of Malignancy Index → Menopausal score x USS score x Ca-125=

18
Q

What is the first line of imaging for a suspected ovarian cancer?

A

Ultra sound scan

19
Q

What conditions other than ovarian cancer can give a raised CA-125?

A

endometriosis, viral illness, cirrhosis

20
Q

What is a colposcopy?

A

Magnified, lit view of the top of the vagina and lower end of the cervix.

21
Q

What is cervical cancer directly related to?

A

Human papilloma virus (HPV)

22
Q

What are the symptoms of cervical cancer?

A
  • Abnormal vaginal bleeding
  • Vaginal discomfort
  • Malodorous discharge
  • Dysuria
23
Q

What is the leading cause of cancer-related death for women in developing countrie?

A

Cervical cancer

24
Q

Where do cervical cancers form in the cervix?

A

The transformational zone → squamocolumnar junction