Gynae Cancers Flashcards

1
Q

A 46-year-old woman with a history of cervical carcinoma treated by radiotherapy presents with a history of constant leaking of urine. She is required to wear a pad day and night. Choose the most appropriate diagnosis

a) Atrophic vaginitis

b) Carcinoma of the bladder

c) Detrusor instability

d) Vesicovaginal fistula

e) Urinary infection

A

d) Vesicovaginal fistula

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2
Q

Characteristic symptoms of ovarian carcinoma include

a) abdominal pain

b) weight change

c) abnormal uterine haemorrhage

d) vaginal discharge

e) none of the above

A

e) none of the above

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3
Q

The following statements relating to gynaecological cancer is CORRECT

a) 75% of patients with cancer of the vulva are under 50 years old

b) Nulliparous are at higher risk of Endometrial cancer than in parous women

c) Ovarian cancer presents characteristically with post-menopausal bleeding

d) Carcinoma of the vagina is a disease of the elderly woman only

e) Cervix cancer is the major cause of cancer related death in women

A

b) Nulliparous are at higher risk of Endometrial cancer than in parous women

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4
Q

Which of the following statements concerning ovarian carcinoma is CORRECT

a) Classically it presents early with bleeding

b) It occurs more commonly before the menopause

c) Human papilloma virus is implicated aetiologically

d) There is a lower incidence in women who have taken the combined oral contraceptive pill

e) There is a recognised association with high parity

A

d) There is a lower incidence in women who have taken the combined oral contraceptive pill

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5
Q

Risk factors for cervical intraepithelial neoplasia (CIN) include all of the following except

a) early age of first intercourse

b) smoking

c) presence of HPV on previous smears

d) more than one sexual partner

e) family history of cervical cancer

A

e) family history of cervical cancer

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6
Q

Serum CA125 is typically raised in association with:

a) Candidal vaginitis

b) Epithelial ovarian cancer

c) Spina bifida

d) Utero-vaginal prolapse

e) Vulvar carcinoma

A

b) Epithelial ovarian cancer

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7
Q

Which of the following are risk factors for endometrial cancer?

a) Type 1 Insulin dependent diabetes

b) Early menopause

c) Oral contraceptive pill

d) Combined oestrogen and progesterone HRT

e) Hereditary non polyposis coli cancer syndrome

A

e) Hereditary non polyposis coli cancer syndrome

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8
Q

Which of the following is NOT a risk factors for ovarian cancer?

a) Nulliparity

b) Smoking

c) Low socio economic class

d) Oral contraceptive pill

e) Non insulin dependent diabetes

A

d) Oral contraceptive pill

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9
Q

Which of the following is a risk factors for mucinous ovarian cancer?

a) Nulliparity

b) Smoking

c) Low socio economic class

d) Oral contraceptive pill

e) Non insulin dependent diabetes

A

b) Smoking

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10
Q

Which of the following is a risk factors for mucinous ovarian cancer?

a) Age

b) Smoking

c) Family History

d) Oral contraceptive pill

e) Pregnancy

A

b) Smoking

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11
Q

Which of the following statements is true regarding the investigation of women with post menopausal bleeding?

a) Vaginal ultrasound scan and dilatation and curettage have similar sensitivity for the detection of endometrial cancer

b) A woman with post menopausal bleeding who has an endometrial thickness of less than 4 mm has less than 1 chance / 1000 of having endometrial cancer

c) Approximately 1 / 10 women with endometrial cancer have an endometrial thickness of 4 mm or less

d) A, b + c are false

e) A, b, + c are true

A

e) A, b, + c are true

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12
Q

Which of the following statements regarding tumour markers are true?

a) Postmenopausal women with a complex ovarian mass with solid and cystic areas and a CA 125 of greater than 35 have a greater than 75% risk of having ovarian cancer

b) Serum alpha Fetoprotein is markedly elevated in young women with endodermal sinus tumours.

c) CA125 levels may be elevated in the presence of pregnancy, endometriosis and pelvic inflammation

d) a, b + c are false

e) a, b + c are true

A

e) a, b + c are true

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13
Q

The following are NOT common problems in the palliative care of women with advanced epithelial ovarian cancer

a) Abdominal discomfort due to ascites

b) Breathlessness and chest pain due to pleural effusion

c) Depression

d) Pain due to bony metastasis

e) Vomiting and abdominal pain due to small bowel obstruction

A

d) Pain due to bony metastasis

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14
Q

Ms NW, aged 19 years, has never been pregnant. She complains of sudden onset of pain with nausea. She is taking the combined oral contraceptive pill. On pelvic examination there is tender fullness of the right fornix and ultrasound examination shows an 8cm cystic and solid mass replacing the right ovary. Indicate the most likely diagnosis.

a) Corpus luteum cyst

b) Cystadenocarcinoma

c) Benign cystic teratoma

d) Follicular cyst

e) Granulosa cell tumour

A

c) Benign cystic teratoma

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15
Q

The following is true of invasive cancer of the vulva.

a) Melanoma is more common than adenocarcinoma

b) Squamous carcinomas of the vulva arise in approximately 3% of women following treatment of VIN3

c) It has a bimodal distribution by age

d) Is diagnosed in approximately 5% of women on removal of a VIN3 lesion

e) All of the above are correct

A

e) All of the above are correct

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16
Q

About the HPV vaccine

a) The vaccine is safe in pregnancy

b) Girls up to 18 years old are eligible for free immunisation

c) Gardasil and Cervarix are included in the NZ Immunisation Schedule.

d) Studies have shown that the vaccine used in NZ is effective in preventing persistent infection with HPV in 96% of women

e) HPV types covered by the Gardasil vaccine are 16, 18, 31 and 35.

A

d) Studies have shown that the vaccine used in NZ is effective in preventing persistent infection with HPV in 96% of women

17
Q

Which one is NOT a function of the National Cervical Screening Programme?

a) A reminder is sent to a woman who is overdue for her smear

b) Monitors the screening register

c) Send a results letter to the woman

d) Sends annual reports to smear-takers about the quality of the smears performed by them

e) Audits DHBs performance and adherence to the programme’s policies and standards

A

c) Send a results letter to the woman

18
Q

Screening is effective in:

a) Endometrial cancer

b) Ovarian cancer

c) Cervical cancer

d) Vulval cancer

e) Fallopian tube cancer

A

c) Cervical cancer

19
Q

Which of the following has no premalignant risk for vulval cancer?

a) Lichen Sclerosus

b) Lichen Planus

c) Usual type VIN

d) Differentiated VIN

e) Lichen Simplex

A

e) Lichen Simplex

20
Q

Genetic mutations (BRCA and HNPCC) do not raise the risk of:

a) Breast cancer

b) Bowel cancer

c) Cervical cancer

d) Endometrial cancer

e) Ovarian cancer

A

c) Cervical cancer

21
Q

Which of the following is not used to calculate RMI (risk of malignancy index) for ovarian masses?

a) Menopausal status

b) Ca125

c) Ultrasound findins of bilateral tumours

d) Ultrasound findings of ascites

e) CT findings of solid tumour

A

e) CT findings of solid tumour

22
Q

Which of the following tumour markers are not useful in ovarian malignancies?

a) Ca 15-3

b) CEA

c) Ca 125

d) hCG

e) Inhibin

A

a) Ca 15-3

23
Q

Cervical cytolgical screening in New Zealand:

a) The primary aim is to detect early cancers

b) Thinprep is proven to prevent more cervical cancers than conventional cytology

c) HPV testing is likely to become a useful adjunct to cytology in screening women under 30

d) Approximately 72% of eligible women in New Zealand have had a smear in the last 3 years

e) All of the above are correct

A

d) Approximately 72% of eligible women in New Zealand have had a smear in the last 3 years

24
Q

The following statement is true regarding cervical HPV infection.

a) A minority sexually active women contract cervical HPV infection in their lifetime

b) The peak incidence of HPV infection is in The 30–35 yr age group

c) Cervical infection with “high risk” HPV is normally transient lasting less than 12 months.

d) Smoking does not influence the likely hood of development of CIN in HPV positive women

e) All of the above are correct.

A

c) Cervical infection with “high risk” HPV is normally transient lasting less than 12 months.

25
Q

Which of the following statements is FALSE regarding the investigation of women with post menopausal bleeding (PMB)?

a) Vaginal ultrasound scan and dilatation and curettage have similar sensitivity for the detection of endometrial cancer

b) A woman with post menopausal bleeding who has an endometrial thickness of less than 4 mm has less than 1 chance / 1000 of having endometrial cancer

c) Approximately 1 / 10 women with endometrial cancer have an endometrial thickness of 4 mm or less

d) A pipelle sample showing cancer avoids the need for a hysteroscopy and curettage

e) A woman with PMB should be advised that cancer is the reason for the bleeding in 8/10 cases

A

e) A woman with PMB should be advised that cancer is the reason for the bleeding in 8/10 cases

26
Q

Which of the following statements regarding tumour markers is FALSE?

a) Postmenopausal women with a complex ovarian mass with solid and cystic areas and a CA 125 of greater than 35 have a greater than 75% risk of having ovarian cancer

b) Serum alpha Fetoprotein is markedly elevated in young women with endodermal sinus tumours.

c) CA125 levels may be elevated in the presence of pregnancy, endometriosis and pelvic inflammation

d) A woman with an RMI (risk of malignancy index) of 200 or more should have a referral sent to a gynae-oncology service

e) CA125 should be arranged as a first line investigation for a woman with pelvic pain and a possible adnexal fullness on examination.

A

e) CA125 should be arranged as a first line investigation for a woman with pelvic pain and a possible adnexal fullness on examination.