GYN Pathology Flashcards
Mullerian ducts
The uterus, fallopian tubes and upper vagina develop from the Mullerian ducts (paramesonephric ducts).
Most uterine and cervical anatomical variants are caused by failure of development of Mullerian ducts at some stage of development
Because of the close developmental relationship between the genital ducts and urinary system, there is a common association of anomalies of both systems.
-Should evaluate the urinary tract in all cases of uterine anomalies!
Uterine agenesis
Failure of the caudal mullerian ducts to develop
Fallopian tubes are present but not uterus
Amenorrhea
Arcuate Uterus
Septum between mullerian ducts is almost completely reabsorbed with only mild indentation of endo of the fundus
Least severe anomaly
Can be asymptomatic or cause infertility
Bicornuate Uterus
Partial fusion of the mullerian ducts
Two uteri in the superior portion of the uterus
Two superior endometrial cavities
Can be asymptomatic or cause infertility and spontaneous abortion
Didelphys Uterus
Complete failure of the mullerian ducts to fuse
Complete duplication of uterus, cervix, and vagina
Asymptomatic
Infertility, spontaneous abortion and vaginal septation can occur
Septate Uterus
Complete fusion of the mullerian ducts with failure to completely reabsorb the septum
Two uterine cavities and one uterine fundus
Asymptomatic
High incidence of infertility and multiple spontaneous abortions
Subseptate Uterus
Complete fusion of the mullerian ducts with partial failure to completely reabsorb the septum
Asymptomatic
Infertility can occur, as well as multiple spontneous abortions
Unicornuate Uterus
Unilateral development of the paired mullerian ducts
Asymptomatic, hypomenorrhea, and infertility can occur
Small uterine size and lateral uterine position
Leiomyoma
Also known as a fibroid, myoma or fibromyoma
Most common tumor of the female pelvis
They are benign, smooth muscle tumors which are usually multiple and have greater incidence in black, nulliparous women
Usually located in uterine corpus but can also be found in the cervix and broad ligament
Described by their location in relationship to uterine wall:
- Submucosal: beneath the endo cavity and often projects into uterine cavity; most commonly produce symptoms (uterine bleeding); distorts endo
- Intramural/ interstitial: within the myometrium; distorts myometrium
- Subserosal: Beneath the perimetrium; distorts uterine contour
- Intraligamentous: between the layers of the broad ligament
- Cervical: uncommon
- Pedunculated: On a pedicle or stalk; only occurs with submucosal and subserosal; torsion may occur
Clinical findings of a leiomyoma
- Often asymptomatic
- Heavy periods (menometrorrhagia) especially with submucosal myomas
- Frequent urination
- Enlarged uterus on pelvic exam
- Increasing pain with degenerative changes
- Infertility or spontaneous abortions
- Alteration in normal menstrual flow
Sonographic findings of leiomyoma
Dependent on amount of degeneration, size and location of fibroid
- Well circumscribed hypoechoic mass
- Lobulated uterine contour
- Shadowing (with increased attenuation and calcific degeneration)
- Displacement of endometrial echoes
- Extrinsic compression of posterior bladder wall
- Pedunculated fibroid may appear as hypoechoic adnexal mass
Adenomyosis
Benign invasion of endometrial glands and stroma into the myometrium
Can be diffuse or focal and most often affects posterior myometrium
Risk factors:
- Multiparity
- Elevated estrogen
- Aggressive curettage
- Women ages 30-50
Clinical findings:
- Pelvic pain/cramping
- Uterine enlargement & tenderness on physical exam
- Menorrhagia
- Dysmenorrhea
Sonographic findings:
- Enlarged uterus with normal contours
- Asymmetric thickening of anterior and posterior uterine wall
- Myometrial cysts (2-6 mm)
- Inhomogeneous myometrium
- “Venetian blind” type shadowing
Cervical carcinoma
Second most common GYN malignancy
Typically seen in women ages 20-30
Symptoms:
- Post-coital vaginal bleeding (most common)
- Palpable mass
- Weight loss
- Vaginal discharge
- Asymptomatic
Risk factors:
- HPV infection
- Early sexual activity
- Multiple sex partners
- Smoking
- OCP use
Sonographic findings:
- Normal appearance in early disease
- Enlarged/ bulky cervix
- May appear similar to cervical myoma
- Hydronephrosis
- Involvement of other pelvic organs
Nabothian cyst
Mucus retention cyst due to obstructed and dilated endocervical glands
Common, benign and of no clinical significance
Sonographic findings:
- Small, well circumscribed, anechoic structure located within cervical wall
- Posterior acoustic enhancement
Hydrometra
Collection of serous fluid within endo cavity
May be secondary to:
- Cervical stenosis (esp. post-menopausal pts)
- Endometrial ablation
- Pelvic radiation therapy
Uterine Arteriorvenous malformation (AVM)
May be congenital but more commonly acquired after surgical procedure or uterine trauma
Associated with heavy vaginal bleeding
Sonographic findings:
- Hypoechoic myometrial abnormality
- Abundant flow on color doppler
- Low resistance, high velocity flow on spectral doppler
Endometrial carcinoma
Most common GYN malignancy
Associated risk factors:
- Obesity
- Postmenopausal (75-80% of cases) with an increased risk if on estrogen replacement therapy
- History of atypical hyperplasia of endo
- History of Tamoxifen therapy
- Strong family history of uterine cancer
Clinical signs:
- Postmenopausal vaginal bleeding
- Hypermenorrhea, intermenstrual flow in patients still having periods
- Pain as result of uterine distension
Sonographic findings:
- Alteration in size, shape, and sono texture of uterine parenchyma
- Increased uterine size
- Inhomogencity and thickening of endo echoes ( >4-5 mm)
- Fluid in endo cavity
Endometrial hyperplasia
Proliferation of endometrial glandular tissue that can be focal or diffuse
25 % of patients with atypical hyperplasia will undergo malignant changes (progressing to endo carcinoma)
Most common cause of abnormal uterine bleeding
Causes:
- Unopposed estrogen hormone replacement therapy
- Persistent anovulatory cycles
- PCOS
- Obesity
- Estrogen producing tumors of the ovary (granulosa cell tumor and thecomas)
Sonographic findings:
- Smooth borders
- Prominent thickening of the endometrium with/without cystic changes
- More homogenous texture
- Premenopausal women thickness >14 mm
- Patient on Tamoxifen >10 mm
- Postmenopausal women on estrogen only >5 mm
- Postmenopausal women in estrogen phase can be up to 8 mm, and when in progesterone phase, will decrease
Endometrial polyps
Localized overgrowths of endometrial tissue which may be pedunculated, broad-based, or have a thin stalk.
-Occasionally, the stalk will be so long that it will prolapse into the cervix or even the vagina
Clinical signs:
- Usually asymptomatic
- Infertility
- Abnormal uterine bleeding
- Usually discovered by accident in D&C
- Occasionally causes postmenopausal bleeding
Sonographic findings:
- Non-specific thickened endo, usually focal but can be diffuse
- Discrete mass in endo, focal, round and echogenic
- Possibly vascular stalk demonstrated with Color Doppler
- May indistinguishable from endometrial hyperplasia
- Sonohysterography is ideal for demonstrating size and location
Endometritis
Causes:
- Pelvic inflammatory disease
- Retained products of conception
- Postprocedural complication
- Vaginitis
Clinical signs:
- Pelvic pain
- Fever
- Leukocytosis
Sonographic findings:
- Thick and irregular endo
- Pronounced endo
- Enlarged, inhomogeneous uterus
- Hypervascular endo and myometrium
Saline Infusion (Sonohysterography- SIS)
A technique of introducing saline into the endo cavity to evaluate the endo with ultrasound.
- Images are obtained in two planes
- External os is cleansed and catheter is placed into cervix
- Sterile saline is infused during TV ultrasound
Indications for exam:
- Infertility and habitual abortion
- Congenital anomalies and/or anatomical variants of uterine cavity
- Pre and post-op evaluation of uterine cavity (esp. w/ myomas, polyps, and cysts)
- Suspected uterine cavity synechiae (scarring associated with Asherman’s syndrome)
- Further evaluation of abnormalities detected by US
***Asherman’s syndrome= adhesions from previous deep curettage or endo infection
Physiologic cysts
Simple (anechoic, unilocular, thin-walled) cystic mass related to either ovary measuring less than 3 cm (WNL)
Approximately 60% of ovarian cysts resolve spontaneously
Functional cysts that are benign:
- Follicular
- Corpus luteal
- Theca lutein
Follicular cysts
Caused by over-stimulation of a follicle that fails to rupture/ involate
Serous fluid-filled cyst that measures 3-8 cm