Gyn And GU cancers Flashcards
Ovarian Cancer risk factors
Age
Early menarche (<12)
Late menopause>52
HRT or fertility drugs
1st pregnancy > 30 years
Obesity
Factors that decrease endocrine/repro cancers
Multiparity
Breast feeding
Oral contraceptives
Oopherectimy
Tubal ligation
Genes that salpingo oophorectomy are removed
BRCA1/2
LYNCH
BRIP1
RAD51C
RAD51D
Uterine/endocrine cancer risk factors
Obesity
Age
Class, race, fhx
Irregular periods
Early period, late menopause
Low or nulliparity
Infertility
Diabetes
Hypertension
Estrogen replacement therapy and/or tamoxifen
Hereditary predisposition
Symptoms of uterine/endometrial cancer
Unusual vaginal spotting
Bleeding
Discharge
Pain in the pelvic region
Presence of a lump
Genes associated with prostate cancer
Brca 1/2
Lynch
ATM
CHEK2
BHOXB13
TP53
PALB2 & RAD51D
Three types of Burt Hogg Dube lesions
Folliculomas
Trichodiscomas
Acrochordons (skin tags)
Birt Hogg Dube gene affected, inheritance, on what chromosome
AD, FLCN, Chromosome 17
Additional BHD symptoms
Oral mucosal polyps and lipomas
Multiple renal carcinomas 15-30% (chromophobe and oncocytic)
Pulmonary cysts 70%
Spontaneous pneumothorax 25%
Renal cancers in BHD and %
Chromophobe 34%
Oncocytoma 5%
Hybrid chromophobe oncocytoma 50%
Clear cell 9%
Papillary 2%
Features of Hereditary Leiomyomatosis and Renal Cell Cancer
Cutaneous leiomyomata
Renal cancer
Uterine fibroids
HLRCC gene affected and inheritance
Fumarse hydratase (FH)
AD
Tuberous Sclerosis genes affected and inheritance
TSC1 or 2
AD
Tuberous Sclerosis percentage of sporadic (new mutations)
~60-70%
Kidney findings in TSC
Angiomyolipomas (80%)
Benign hematomas
PKD <5§)
Simple cysts (20%)
Renal cell carcinoma (<1%
