gyn Flashcards
definition of primary amenorrhea
absence of menses by age 16
deginition of secondary amenorrhea
in a woman who has previously had mesnes it is the absences by 3 months
primary amenorrhea is divided into these four categories
gonadal dysgenesis (turner)
hypothalamic pit insufficiency
androgen insensitivity
imperforate hymen
in a women with normal estrogen the most likely secondary cause of amenorrhea i
asherman’s syndrome (intrauterine synechiae)
or
PCOS
in women with hypoestrogen secondary amenorrhea is most likely due to these three casues
CNS tumor
hyperprolactinemia
or
PCOS
diagnostic studies for secondary amenorrhea
first line is b HCG fr pregnancy
TSH
and prolactin
secondary tests ordered for secondary amenorrhea
FSH
estrogen
LH
and testosterone
primary dysmenorrhea is caused by
Primary is painful mensuration caused by
excess prostaglandin and leukotriene levels leading to painful uterine contractions nausea vomiting and diarrhea
onset is usually within 2 years of menarche
NO PATHOLOGICAL ABNORMALITY
Secondary dysmenorrhea (4)
painful mensuration caused by an identificale clinical condition usually of the uterus or the pelvis
endometriosis
adenomyosis (growth of endometrial tissue in the wall of the uterus)
uterine fibroids
PID
and IUD
primary dysmenorrhea usually peaks during
late teens and early 20s and incidence of secondary dysmenorrhea increases with age
what is the karyotype of turners
what are the hormones associated
45 XO
high FSH
What is the treatment for tuenr’s syndrome
cyclic estrogen and progesterone
what is the hypo pit insufficiency look like in a pt with primary dysmenorrhea
what is the treatment
NO breast development
46 XX
low FSH
low LH
give cyclic estrogen and progesterone
what does androgen insensitivity look like in a pt with primary dysmenorrhea
46 XY
normal breast development
high testosterone
what is the treatment for androgen insensitivity
remove the testes and start estrogen
how does sxs of secondary dysmenorrhea differe from sxs of primary dysmenorrhea
secondary symptoms are more likely to
include bloating
menorrhagia
dysparunia
and less likely related to the first day of lfow
primary dysmenorrhea treatmetn
start NSAIDS just before the expected menses and continue for 2-3 days
OCP vitamin B magnesium ancupuncture application of heat regular exercise also help to reduce pain
for resistant cases of primary dysmenorrhea try
tocolytic agents
CCB
progestogens
what are the tests done for evaluating secondary casuses of dysmenorrhea
hysteroscopy
D and C
larproscopy
what is PMS syndrome what is the hypothesized cause
abnormal levels of estrogen, progesteron cortisone prolactin and antidiuretic hormone as well s endogenous opiates melatonin serotinonin prostaglandins vitamin and mineral deficiencies reactive hypoglycemia menstural toxins pyschological social evolutionary and genetic factors
the reported incidence of PMS is
10-90% with 10% debilitated
prevalence is greatest during the fourth and fifth decade
association exists between PMS and
postpartum depression
perimenopausal depression
other affective disorders
clinical features of PMS
Associated with the menstrual cycle and being 1 to 2 weeks before menses during the leutal phase and end 1 to 2 days after the onset of menses
what must exist in order to have PMS
a monthly symptom free period during the follicular phase from day 1 to ovulation
most common complaints with pms are
mood changes and psychological affects
PMS symptoms outside of mood changes
fluid retention edema weight gain breast pain
backache, constipation
lifestyle modifications for PMS
caffeine reudction salt restriction low fat high complec carb intake magnesium vitamin B relaxation stress reduction
drug treatment for PMS
pyridoxine (vitamin B6) and evening primrose oil show NO BENEFIT over placebo in clinical trial but relieve breast tenderness and depression in some women
calcium carbonate
magnesium
B6 and vitamin E supplementation have been shown to benefit some women
nsaids
SSRI
what can be used to relieve breast tenderness in PMS
spironilactones
bromocroptine may relieve mastalgia
what antianxiety medications can people use from PMS
buspirone or alprazolam
vasomotor symptoms with menopause usually resolve within
2 to 3 years
3 to 6 weeks with estrogen replacement therapy
urogenital atrophy can cause what kind of incontinence
urge incontinence
can also cause atrophic cystitis and easy bleeding
other than hot flashes and vaginal atrophy what other sxs do you see with menopause
changes in sleep cycle skin becomes thin and loses elasticity increased facial hair hair lose nails become brittle confusion nloss of mempry
diagnostic studies for menopause
increased FSH greater than 30
menopause management
regular exercise
HRT but this increases the risk of cardiovascular disease breast cancer and cognitive changes
other potential risks include gallbladder disease and migraines
CI to HRT (4)
Undiagnosed vaginal bleeding
acute vascular thrombosis
liver disease
history of endometrial of breast cancer
what meds can be described for women at risk of steoperosis
Ca and vitamin D
bisphosphinates
SERMS (selective estrogen recpetor medulators)
or calcitonin
what alternative treatments are available for women in menopause
soy
black cohosh
ginseng can help relieve symptoms
DUB is defined as
abnormal bleeding in the absences of an anatomic lesion usually caused by a problem with the hypo pit ovarian system
when is DUB most liekly to occur
shortly after menarch or in peri-menopause other causes include PCOS exogenous obesity and adrenal hyperplasia
diagnostic studies for DUB
b hcg CBC PT PTT documentation of ovulation TSH serum progesterone LFT prolactin serum FSH levels
what would be done to investigate DUB
pap endometrial biopsy ultrasonography hyterosalpingography hysteroscopy and or Dand C
management of DUB
observation iron therapy and volume replacement may be needed
oral high dose estrogens might ald=so be indicated
a progesterin trial should be performed and if the bleeding stops the cycles are confirme d
OCP for DUB
older women without risk factors can be prescriped OCP SHOULD NOT be used in women who smoke have hypertension DM hx of vascular disease breast cancer liver disease focal headaches
what can you use in younger pts with DUB
cyclic progestins
refractory cases of DUB might require
endometrial ablation of vaginal hysterectomy
leiomyoma are most common during
uterine fibroids are most common in the fourth decade of life in black women and those with positive family hx
fibroids depend on
estrogen and appear with increased frequency in
women with endometrial hyperplasia,
anovulatory states,
and estrogen producing ovarian tumors
fibroids can be classified by
their location
subserous (deforming external serosa)
intramural (within uterine wall)
submucous (deforming the uterine cavity) .
what kind of fibroids cause bleeding
submucousa
bleeding is the most common symprom
what are the clinical features of fibroids
msot have no sxs
sometimes you can feel a enlarged uterine mass
some will have symptoms of a full pelvis
menorrhagia
metrorrhagia
intermenstural bleeding
dysmenorrhea
what is the risk to pregnant women with leiomyoma
spontaneous abortion
diagnostics for fibroids
D&C
saline hysteroscopy
hysterosalpinography
laparascopy
why would you get LFTs in a pt with dub
You rule out liver disease that would cause them to not make clotting factors. So the bleeding is because of coagulopathy issues.
why are OCP CI with livr disease
The liver metabolizes estrogen, so its CI with liver disease.Is the bottom line
liver disease that happens in pregnancy
Cause also in pregnancy when estrogen levels are extremely high it can precipitate intrahepatic cholestasis of pregnancy (ICP)
managment of leiomyoma
observation
symptomatic pts can undergo myomectomy, hysterectomy or D and C
can also do endometrial ablation
how to use gnrh for leiomyoma
gnrh agonists and mifepristone may reduce tumor size in women with small leiomyoma
gnrh agonist may restore fertility
treatment is limited to 6 mo
Medroxyprogesterone acetate what is it and how do we use it in PCOS
depot medroxyprogesterone acetate (DMPA) and sold under the brand name Depo- Provera
Medroxyprogesterone acetate given on the first 10 days of each month will promote regular shedding of the endometrium. If contraception is desired, a low dose oral contraceptive can be used.
_________ is the most common type of endometrial carcinoma.
Adenocarcinoma is the most common type of endometrial carcinoma. In the US, 80% of endometrial carcinomas are of this type. Longer exposure to estrogen (i.e., early menarche, late menopause, and diabetes) is a risk factor for carcinoma.
_______ is a choice for a patient with symptomatic fibroids who would like to maintain fertility
Myomectomy is a choice for a patient with symptomatic fibroids who would like to maintain fertility and retain the uterus. There is, however, a significant risk for recurrence of leiomyomas
HSIL is associated with a high risk of ____
what is the managment
HSIL is associated with a high risk of CIN 2,3 or cervical cancer. In women 25 and older management with immediate colposcopy or LEEP is based upon these risks.
Immediate cervical ablation should not be performed because ablative procedures do not provide a specimen for diagnostic evaluation.
at what age group would you not do diagnostic procedure for HSIL
the recommendations for follow-up for abnormal cervical screening results differ for women ages 21 to 24 years from those for women 25 and older.
They advise a diagnostic excisional procedure only if abnormal results are severe or recurrent.
)________ is the safest and most effective method for termination of pregnancies up to 12 weeks. The majority of induced abortions in the US are via suction curettage.
Suction curettage is the safest and most effective method for termination of pregnancies up to 12 weeks. The majority of induced abortions in the US are via suction curettage.
when can you use misoprostil for an TAB
This patient is at 10 weeks and is therefore not eligible for medical abortion which is appropriate when a woman presents less than 49 days from LMP
first line treatment for HTN in pregnancy
methyldopa has the benefit of more research/studies and is recommended as the first-line treatment for hypertension in pregnancy.
first-line treatment for hypertension in pregnancy.
Methyldopa has the benefit of more research/studies and is recommended as the first-line treatment for hypertension in pregnancy.
how can you differentiate cervical insufficiency vs SAB
his patient presents with cervical insufficiency. This is still a viable pregnancy because she has no abdominal cramping and she is now in the 2nd trimester but she is starting to dilate. A cervical cerclage is recommended between 13-16 weeks’ gestation
when would you do a cervical cerclag
A cervical cerclage is recommended between 13-16 weeks’ gestation
what is the workup for infertility in female
In the initial evaluation of the female partner, noninvasive procedures, such as the measurement of LH and mid-luteal phase progesterone (to determine ovulatory function) and TVUS (to rule out the possibility of fibroids or polycystic ovaries), are first-line investigations.
CI to cerclage
placement include bleeding of unknown etiology, infection, labor, ruptured membranes and fetal anomalies.
In patients with irregular cycles, secondary to chronic anovulation, or oligo-ovulation, combined oral contraceptive (COC) pills help to ….
In patients with irregular cycles, secondary to chronic anovulation, or oligo-ovulation, combined oral contraceptive (COC) pills help to prevent the risks associated with prolonged unopposed estrogen stimulation of the endometrium.
what would you do for a pt with anovulatory cycles and a CI to COC
Treatment with cyclic progestins for days 16 through 25 following the first day of the most recent menstrual flow is preferred when OCP use is contraindicated, such as in smokers older than age 35 and women at risk for thromboembolism.
how to treay leiomyoma bleeding
The heavy bleeding that typically accompanies fibroid tumors can be minimized by using intermittent progestin supplementation (depot methodroxyprogesterone acetate 150 mg IM every 28 days) and/or prostaglandin synthetase inhibitors.
treatment form chlamydial PID
One recommended outpatient treatment is Ofloxacin 400 mg once daily for 14 days; with or without metronidazole 500 mg twice daily for 14 days.
what are symptoms of a ovarian cyst and what is indicated
Symptoms associated with a functional ovarian cyst include mild to moderate unilateral pain and alteration in the menstrual cycle. On occasion, rupture of the follicular cyst causes acute pelvic pain and may need laparoscopic surgery for complete evaluation. In most cases, pain control for 4 to 5 days is what is indicated as well as the consideration of contraception to suppress future ovarian cyst formation.
A very firm ovarian mass estimated at 8 cm is found in a 33-year-old woman at her annual examination. what would you expect
The size and firmness of the ovarian mass suggests endometrioid carcinoma, a tumor in which the potential for malignancy is 100%
Based on the latest ASCCP guidelines women ages 21-24 years of age with LSIL should undergo repeat cytology at
Based on the latest ASCCP guidelines women ages 21-24 years of age with LSIL should undergo repeat cytology at 12 months. Those 25 and up with LSIL should undergo colposcopy.
what is the diagnosis of atrophy
ph
apperance
discharge
Atrophy is diagnosed by the presence of a thin, clear, or bloody discharge;
a vaginal pH of 5 to 7;
loss of vaginal rugae; and
the finding of parabasal epithelial cells on microscopic examination of a wet-mount preparation. These symptoms are all due to estrogen depletion
AUB mneumonic
PALM COEIN
structural- polyp adenomyosis Leiomyoma Malignancy
non structural - coagulopathy Ovulatory dysfunction endometrial iatrogenic not otherwise classified
what falls under the heading of irregular bleeding
any change from normal HMB HPMB IMB PMB
risk factors for endometrial can
nulliparity infertility late meno DM unopposed estrogen hypertension gallbladder disease chronic tamoxifen use
NOT RELATED TO SEXUAL HX
to OCP have protective risk factors for endometrial Ca
yes
what are the clincal features of endometrial ca aside from pmb
Obesity
htn
dm
with PMB what tests should you run
ULS (Look at stripe)
pap
EMB (endometrial biopsy)
what is the definitive choice for endometrial cancer diagnostic
endocervical curretage
but EMB has an accuracy of 90-95%
management of endometrial cancer
total hysterectomy combined with b/l salpingo-oopherectomy drives treatment and staging
radiotherapy may be indicated and chemo is used at advanced stages
reoccurrence is treated with high dose progestins and antiestrogen
how does endometriosis manifest
deep thrust dyspareunia dyschezia dysmenorrhea intermitten spotting pelvic pain infertility
signs of endometriosis
tender nodularity of the cul-de-sac and uterine ligaments and a fixed uterus
the degree of symptoms does not correlate with the degree of disease
how do you diagnose endometriosis
usually it is a diagnosis of exclusion using the ULS to rule out other pathology but you can get a definitive diagnosis laparoscopically
treatment for the relief of sxs in endometriosis
NSAIDs and prostoglandin synthesis
OCP
or progestins may relieve symptoms
surgical options for endometriosis
can resect larger endometriomas
can treat with danzol or a gnrh agonist around the time of surgery fro improved fertility
predisposing factors to prolapse
white hispanic obesity chronic cough constipation repetitive heavy lifting
(anything that increases intra abdominal pressure)
COPD
asthma
ascites
pelvic tumors
non surgical management of prolapse includes
weight reduction
smoking cessation
pelvic muscle exercises
use of vaginal pessary
surgical option for uterine prolapse
hysterectomy
name three different types of functional cysts
follicular
corpus luteum
lutein cysts
clinical features of cysts
pain with menstruation
hemorrhage secondary to rupture
or
asymptomatic
management of cysts
follow for one or two cycles if small than 8cm
with large or persistent laprascopic evaluation
cysts in postmenopausal women are
malignant until proven otherwise
PCOS pts are at increased risk for
endometrial cancer because of unopposed estrogen and endometrial hyperplasia
how people describe uLS of PCOS
String of pearls or
oyster ovaries
who is at risk of ovarian ca
family jc white older than 69 nulliparious positive hx of endometrial cancer
90% of cases are sporadic
OCP are have or have not been proven to be preventative in ovarian cancer
have been preventative
5th MCC of cancer and the 2nd most common gynecological malignancy
symptoms of ovarian cancer
ascites abdominal distention early satiety changes in bowel habits fixed mass
what is a sister mary joseph node
metastatic implant in the umbilicus can be associated with ovarian cancer
diagnostic studies for suspected ovarian cancer
BRCA1 gene associated in 5% of cases
cancer antigen 125 can be used to follow
p53 tumor supressor gene
transvaginal or abdominal ultrasound is useful in distinguishing benign from potentially malignant masses
definitive diagnoses of ovarian ca
biopsy but usually oophorectomy if you think it is malignant
management of ovarian cancer
surgery
chemo
radiation
what HPV strains are likely to be linked to condylomata acuminata
6 and 11
also known as genital warts
what also plays a role in the development of cervical carcinoma
intrepehtial neoplasm
risk factors for cervical cancer
early age at first intercourse multiple sexual partners or high risk sexual partner history of sexually transmitted disease low socioeconomic status cigarette smoking
stages of cervical dysplasia
mild (CIN 1
Mod CIN2
and severe CIN 3
how many pts with CIN 3 progress to frank carcinoma
about 1/3 develop microinvasive or frank carcinoma
difference between occurrence of CIN CIS and cancer
CIN 20s
CIS (in situ) 25-35
cervical cancer age 40