Gyn Flashcards

1
Q

Absent or rudimentary uterus and upper vagina (“short vagina”)
Normal ovaries
Normal breast development
Normal axillary and public hair

A
Mullerian agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome)
46XX

Don’t got tubes! But gonads ok

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Absent uterus and upper vagina
Cryptorchid testes
Normal breasts
Minimal-absent axillary/pubic hair

A

Completely androgen insensitivity syndrome
46 XY

Just a woman with blind pouch vagina with hidden testes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Normal uterus and vagina
Streak ovaries
Breasts are variable
Normal axillary/pubic hair

A

45X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Persistent, eczematous or ulcerative rash on nipple->areola

+/- vesicles, bloody discharge, nipple retraction

A

Paget disease (Adenocarcinoma)

From migration of cancer cells from ducts to nipple surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Palpable, mobile, rubbery, firm breast mass.

No nipple changes

A

Fibroadenoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Unilateral bloody nipple discharge but no nipple lesions

A

Breast papilloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Mobile, soft nontender, well-circumscribed mass behind labium majus
Can cause discomfort

A

Bartholin cysts
(the bartholin glands provide lubrication and are not palpable unless duct is blocked)

Can evolve into abscess (localized erythema, induration, fluctuancy, +/- fever)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Thin white crinkly skin over labia
or “thin dry, white plaque-like vulvar skin” with loss of labia minora
can have clitoral hood retraction

A

Lichen sclerosus
chronic inflammatory condition, can coexist with other autoimmune conditions

dx: punch biopsy to rule out SCC
tx: high-potency topical steroids on genitals!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Bright red autoimmune ulcers and erosions around vulvovaginal area

A

Lichen planus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Leathery skin from chronic scratching

A

Lichen simplex chronicus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Recurrent mild and unilateral mid-cycle pain prior to ovulation. Lasts hours-days

A

Mittelschmerz

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Sudden-onset, severe, unilateral lower abd pain, N/V. Unilateral, tender adnexal mass on exam

A

Ovarian torsion

Ultrasound: enlarged ovary with decreased or absent blood flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

sudden-onset, severe, unilateral lower abd pain immediately following strenous or sexual activity. second half of menstrual cycle.

can result in pelvic free fluid or hemoperitoneum if anticoagulated.

A

ruptured ovarian cyst

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Primary amenorrhea with no breast development

What to get next?

A

FSH

If FSH decreased -> pituitary MRI
if FSH increased -> karyotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Fishy odor
Clue cells
+Whiff test

Tx?

A

BV (gardnerella vaginosis)

tx: metronidazole or clinda

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

yellow-green frothy discharge
pH>4.5
motile tear-shaped organisms

A

trichomoniasis

tx: metronidazole. treat sexual partner too!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

thick, cottage-cheese discharge

A

candida

+pseudohyphae. normal pH

tx: fluconazole

18
Q

Precocious puberty in child
Or bleeding/endometrial hyperplasia in postmenopausal women
Large adnexal mass
Increased estrogen

A

Granuloma cell tumor of ovary

19
Q

Ovarian tumor in women <30yo

Secretes LDH or B-hCG

A

Dysgerminoma

20
Q

Mature teratoma (dermoid cyst)

A

Common, benign ovarian tumor that is not hormonally active

21
Q

Serous cystadenoma

A

Benign ovarian neoplasm. Hormonally inactive and do not cause precocious puberty.

22
Q

Ovarian tumor that produce androgens
Defeminization -> masculinization
-> flattening of breasts and scanty, irregular menstruation -> amenorrhea
Hirsutism, coarsening of facial features, voice depending, clitoral enlargement

A

Sertoli-Leydig cell tumors

23
Q

Ovarian mass

Ultrasound shows hyperechoic nodules and calcifications

A

Mature dermoid cyst (teratoma)

Usually do not rupture, but do increase risk of torsion

24
Q

Uterine cancer following pregnancy that tends to be metastatic on presentation (eg presents with lung nodules)

A

Choriocarcinoma

25
Ovarian masses On ultrasound, bilateral multiseptated cystic masses Induced by high hcg during pregnancy (eg molar pregnancy) Can cause virilization
Theca lutein cysts Should regress spontaneously
26
Pregnant Yellow ovarian masses (half are bilateral) Virilization
Luteoma (High risk of fetal virilization) Should regress spontaneously
27
RUQ pain with PID symptoms (fever, lower abd pain)
perihepatitis (fitz-hugh-curtis disease)
28
How does tamoxifen/raloxifene work? (and what if risk of tamoxifen therapy?)
selective estrogen receptor modulator (SERM) estrogen receptor antagonist in the breast estrogen agonist in the uterus (thus associated with endometrial polyps in premenopausal women, and endometrial hyperplasia/cancer in postmenopausal women)
29
Precocious puberty Bone age > chronological age Low basal LH GnRH stim -> LH still low
Peripheral precocious puberty (GnRH independent) - ADRENAL things (CAH, adrenal tumors) - GONADAL things (gonadal tumors, ovarian cysts) - exogenous (estrogen, etc) - McCune albright (triad: cafe au lait spots, precocious puberty, bone probs)
30
Precocious puberty Bone age > chronological age High basal LH
Central precocious puberty - Idiopathic - Hypothalamic lesions and other CNS tumors
31
Precocious puberty Bone age > chronological age Low basal LH GnRN stim -> LH rises
Central precocious puberty (GnRH dependent) - Idiopathic - Hypothalamic lesions and other CNS tumors
32
Delayed/absent puberty Anosmia Low FSH, LH
Kallman syndrome X-linked recessive defect in migration of fetal GnRH and olfactory neurons -> hypogonadotropic hypogonadism
33
turmor in men b-HCG elevated AFP normal
seminoma
34
tumor in men AFP elevated b-HCG can be elevated
nonseminomatous germ cell tumor (yolk sac, choriocarcinoma, embryonal carcinoma)
35
Condyloma lata vs acuminata
Lata is secondary syphilis, is flat Acuminata is hpv (warts); cauliflower like, usually asymptomatic but can bleed
36
side effect of trastuzumab (herceptin)
cardiotoxicity | Get echo before starting
37
side effect of cisplatin, carboplatin etc
ototoxicity | get baseline audiometry
38
side effect of aromatase inhibitors (anastrozole, letrozole)
(used in tx of postmenopausal estrogen-receptor+ breast cancer) increases risk of osteoporosis get baseline bone density scans
39
side effect of tamoxifen
increases risk of venous thromboembolism maybe get test for factor V leiden and endometrial cancer
40
side effect of bleomycin
pulmonary fibrosis | get baseline PFTs
41
side effect of TNA alpha inhibitors
reactivation of latent TB | get TB skin test
42
how does obesity lead to premature puberty
increased insulin -> adrenal androgen production (->adrenarche), ovarian estrogen production (->thelarche) increased leptin -> premature HPGA axis