Gyn 2 Quiz Flashcards
What 3 conditions constitute primary amenorrhea?
lack of menarche at age of 16, >2 years after onset of puberty or no signs of puberty by age 14
Define secondary amenorrhea.
menses cease >3-6 and the woman is not pg, lactating or menopausal
What are the most common cause of anovulatory amenorrhea?
functional causes (endocrine or genetic)
What is generally occurring with ovulatory amenorrhea?
anatomical genital abnormality with normal hormonal function
Give 3 examples of acquired uterine abnormalities causing ovulatory amenorrhea?
asherman’s syndrom
endometrial tb
obstructive fibroids and polyps
yes
Give 3 examples of congenital genital abnormalities that may result in ovulatory amenorrhea?
cervical stenosis
imperforate hymen
transverse vaginal septum
Give 4 examples of hypothalamic dysfunction that may result in anovulatory amenorrhea?
anorexia nervosa
excessive exercise
hypothalamic chronic anovulation
chronic undernutrition
Give 2 examples of pitutary dysfunction that may result in anovulatory amenorrhea?
galactorrhea (hyperprolactinemia)
benign pituitary adenoma
What are 3 potential disorders involving ovarian failure/dysfunction that may result in anovulatory amenorrhea?
autoimmune d/o
chemo
viral infection
What are 3 potential disorders involving endocrine dysfunction that may result in anovulatory amenorrhea?
PCOS
Cushing’s Syndrome
Hyper/hypothyroidism
What are some signs during hx taking that might suggest hypothalamic anovulation?
change in weight
dietary deficiencies
excessive exercise
environmental stress
What, in hx, might make you think Asherman’s?
Hx of D&C or uterine surgery
meds that might cause virilism or galactorrhea
What are some hx signs of endocrine d/o?
thyroid sxs
virilization: hirsutism, temporal balding, deepening voice
sxs of estrogen deficiency: hot flashes, vag dryness
obesity in hirsute women (PCOS)
What are 4 PEs you would want to do with amenorrhea?
vitals
thyroid
breast exam (looking for nipple d/c)
pelvic (looking for structural abnormalities)
What are some red flags for amenorrhea?
delayed puberty
virilization
visual field defects (prolactinoma)
What are the top three labs to run when someone presents with amenorrhea?
pregnancy test
thyroid study
Prolactin (increase may indicate pituitary tumor)
What are the most common causes of primary amenorrhea?
physiological delay of puberty
functional hypothalamic chronic anovulation
Name 5 common causes of secondary amenorrhea?
pregnancy PCOS Obesity Thyroid dys. hypothalamic dys.
If your pt. is taking drugs that affect dopamine, what might be the possible cause of her amenorrhea?
hyperporlactinemia
If your pt. is taking hormones and/or is on drugs that affect the balance of estrogenic/androgenic effects, what might be the possible cause of her amenorrhea? You may also see signs of virilization with this.
drug-induced virilization
If someone has high BMI (>30) and virilization, what might be the cause of her amenorrhea?
PCOS
Estrogen excess
If someone has low BMI (<18.5) and has risk factors such as a chronic d/o, dieting or an eating d/o, what might be the cause of her amenorrhea?
functional hypothalamic anovulation secondary to eating d/o
If your pt is of short stature and has a webbed neck, primary amenorrhea and widely spaced nipples, what might you consider as the cause?
turner’s syndrome (rare)
Your pt has warm, moist skin, tachycardia and a tremor, what might you be thinking is the cause of her amenorrhea?
hyperthyroidism
Your pt. has course, thick skin, loss of eyebrow hair, bradycardia, delayed DRTs, weight gain and constipation along with her amenorrhea. what might be the cause?
hypothyroidism
Pt. present with acne and signs of virilization along with amenorrhea. What might be the cause?
Androgen excess due to PCOS, an androgen secreting tumor, cushing’s syndrome, adrenal virilism or drugs
You notice striae, moon face, tuncal obesity and thin extremities in your pt. with amenorrhea. What might be the cause?
Cushing’s Syndrome
Your patient has acanthosis nigricans, amenorrhea, virilization and obesity. What might be the cause?
PCOS
You notice vitiligo or hyperpigmentation of the palm as well as orthostatic hypotension in your patient with amenorrhea. What does this pattern suggest?
Addison’s dz
A patient has amenorrhea and sxs of estrogen deficiency (hot flashes, night sweats, etc) and has risk factors such as oophorectomy, chemo or pelvic irradiation. What might be going on?
premature ovarian failure
A young woman comes in with primary amenorrhea, hirsuitism and virilism. What are some possibilities for the cause?
androgen excess due to hermaphroditism, an androgen-secreting tumor, adrenal virilism, gonadal dysgenesis.
A woman comes in with primary amenorrhea, enlarged ovaries, hirsuitism and virilism. What are some possibilities for the cause?
androgen excess due to 17-hydroxylase deficiency
PCOS
androgen-secreting ovarian tumor
A pt. has amenorrhea, galactorrhea, nocturnal ha and visual field defects. What might be the cause.
hyperprolactinemia
pituitary tumor
A baby has fused labia and clitoral enlargement at birth. What might be the cause?
androgen exposure during the 1st trimester
drug-induced virilization
What is the most common population to get DUS?
women >45 or in puberty
What percentage of cases of DUS are anovulatory?
90%
What is the classic presentation of DUS?
polymenorrhea
menorrhagia
metrorrhagia
What is the difference in presentation between anovulatory DUB and ovulatory DUB?
anovulatory tends to occur at unpredictable times and not related to the menstrual cycle
ovulatory tends to cause excessive bleeding during menstrual cycle and has signs of ovulation
What are some things you want to r/o with DUB in your hx/PE/Dx?
pregnancy anemia coagulation d/o thyroid problems structural abnormalities hormone imbalance
In which patients would you want to r/o hyperplasia with EMB?
women >35 obese PCOS DM HTN endometrial thickness >4mm
When would you run a GC/CT in the case of DUB?
if PID endometritis or cervicitis is suspected.