Gyn 2 Quiz Flashcards

1
Q

What 3 conditions constitute primary amenorrhea?

A

lack of menarche at age of 16, >2 years after onset of puberty or no signs of puberty by age 14

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2
Q

Define secondary amenorrhea.

A

menses cease >3-6 and the woman is not pg, lactating or menopausal

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3
Q

What are the most common cause of anovulatory amenorrhea?

A

functional causes (endocrine or genetic)

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4
Q

What is generally occurring with ovulatory amenorrhea?

A

anatomical genital abnormality with normal hormonal function

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5
Q

Give 3 examples of acquired uterine abnormalities causing ovulatory amenorrhea?

A

asherman’s syndrom
endometrial tb
obstructive fibroids and polyps
yes

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6
Q

Give 3 examples of congenital genital abnormalities that may result in ovulatory amenorrhea?

A

cervical stenosis
imperforate hymen
transverse vaginal septum

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7
Q

Give 4 examples of hypothalamic dysfunction that may result in anovulatory amenorrhea?

A

anorexia nervosa
excessive exercise
hypothalamic chronic anovulation
chronic undernutrition

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8
Q

Give 2 examples of pitutary dysfunction that may result in anovulatory amenorrhea?

A

galactorrhea (hyperprolactinemia)

benign pituitary adenoma

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9
Q

What are 3 potential disorders involving ovarian failure/dysfunction that may result in anovulatory amenorrhea?

A

autoimmune d/o
chemo
viral infection

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10
Q

What are 3 potential disorders involving endocrine dysfunction that may result in anovulatory amenorrhea?

A

PCOS
Cushing’s Syndrome
Hyper/hypothyroidism

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11
Q

What are some signs during hx taking that might suggest hypothalamic anovulation?

A

change in weight
dietary deficiencies
excessive exercise
environmental stress

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12
Q

What, in hx, might make you think Asherman’s?

A

Hx of D&C or uterine surgery

meds that might cause virilism or galactorrhea

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13
Q

What are some hx signs of endocrine d/o?

A

thyroid sxs
virilization: hirsutism, temporal balding, deepening voice
sxs of estrogen deficiency: hot flashes, vag dryness
obesity in hirsute women (PCOS)

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14
Q

What are 4 PEs you would want to do with amenorrhea?

A

vitals
thyroid
breast exam (looking for nipple d/c)
pelvic (looking for structural abnormalities)

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15
Q

What are some red flags for amenorrhea?

A

delayed puberty
virilization
visual field defects (prolactinoma)

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16
Q

What are the top three labs to run when someone presents with amenorrhea?

A

pregnancy test
thyroid study
Prolactin (increase may indicate pituitary tumor)

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17
Q

What are the most common causes of primary amenorrhea?

A

physiological delay of puberty

functional hypothalamic chronic anovulation

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18
Q

Name 5 common causes of secondary amenorrhea?

A
pregnancy
PCOS
Obesity
Thyroid dys.
hypothalamic dys.
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19
Q

If your pt. is taking drugs that affect dopamine, what might be the possible cause of her amenorrhea?

A

hyperporlactinemia

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20
Q

If your pt. is taking hormones and/or is on drugs that affect the balance of estrogenic/androgenic effects, what might be the possible cause of her amenorrhea? You may also see signs of virilization with this.

A

drug-induced virilization

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21
Q

If someone has high BMI (>30) and virilization, what might be the cause of her amenorrhea?

A

PCOS

Estrogen excess

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22
Q

If someone has low BMI (<18.5) and has risk factors such as a chronic d/o, dieting or an eating d/o, what might be the cause of her amenorrhea?

A

functional hypothalamic anovulation secondary to eating d/o

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23
Q

If your pt is of short stature and has a webbed neck, primary amenorrhea and widely spaced nipples, what might you consider as the cause?

A

turner’s syndrome (rare)

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24
Q

Your pt has warm, moist skin, tachycardia and a tremor, what might you be thinking is the cause of her amenorrhea?

A

hyperthyroidism

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25
Q

Your pt. has course, thick skin, loss of eyebrow hair, bradycardia, delayed DRTs, weight gain and constipation along with her amenorrhea. what might be the cause?

A

hypothyroidism

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26
Q

Pt. present with acne and signs of virilization along with amenorrhea. What might be the cause?

A

Androgen excess due to PCOS, an androgen secreting tumor, cushing’s syndrome, adrenal virilism or drugs

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27
Q

You notice striae, moon face, tuncal obesity and thin extremities in your pt. with amenorrhea. What might be the cause?

A

Cushing’s Syndrome

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28
Q

Your patient has acanthosis nigricans, amenorrhea, virilization and obesity. What might be the cause?

A

PCOS

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29
Q

You notice vitiligo or hyperpigmentation of the palm as well as orthostatic hypotension in your patient with amenorrhea. What does this pattern suggest?

A

Addison’s dz

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30
Q

A patient has amenorrhea and sxs of estrogen deficiency (hot flashes, night sweats, etc) and has risk factors such as oophorectomy, chemo or pelvic irradiation. What might be going on?

A

premature ovarian failure

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31
Q

A young woman comes in with primary amenorrhea, hirsuitism and virilism. What are some possibilities for the cause?

A

androgen excess due to hermaphroditism, an androgen-secreting tumor, adrenal virilism, gonadal dysgenesis.

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32
Q

A woman comes in with primary amenorrhea, enlarged ovaries, hirsuitism and virilism. What are some possibilities for the cause?

A

androgen excess due to 17-hydroxylase deficiency
PCOS
androgen-secreting ovarian tumor

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33
Q

A pt. has amenorrhea, galactorrhea, nocturnal ha and visual field defects. What might be the cause.

A

hyperprolactinemia

pituitary tumor

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34
Q

A baby has fused labia and clitoral enlargement at birth. What might be the cause?

A

androgen exposure during the 1st trimester

drug-induced virilization

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35
Q

What is the most common population to get DUS?

A

women >45 or in puberty

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36
Q

What percentage of cases of DUS are anovulatory?

A

90%

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37
Q

What is the classic presentation of DUS?

A

polymenorrhea
menorrhagia
metrorrhagia

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38
Q

What is the difference in presentation between anovulatory DUB and ovulatory DUB?

A

anovulatory tends to occur at unpredictable times and not related to the menstrual cycle
ovulatory tends to cause excessive bleeding during menstrual cycle and has signs of ovulation

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39
Q

What are some things you want to r/o with DUB in your hx/PE/Dx?

A
pregnancy
anemia
coagulation d/o
thyroid problems
structural abnormalities
hormone imbalance
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40
Q

In which patients would you want to r/o hyperplasia with EMB?

A
women >35
obese
PCOS
DM
HTN
endometrial thickness >4mm
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41
Q

When would you run a GC/CT in the case of DUB?

A

if PID endometritis or cervicitis is suspected.

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42
Q

What is the pattern and quality of pain with dysmenorrhea?

A

occurs with or before menses by 1-3 days
peaks 24 hours after onset of menses
subsides in 2-3 days
sharp or cramping, throbbing or dull, constant ache

43
Q

Where does the pain of dysmenorrhea radiate and what are some concomitant sxs?

A

radiates to the legs

HA, N/D, constipation, LBP, urinary frequency

44
Q

When does primary dysmenorrhea usually begin?

A

in adolescence

45
Q

When does secondary dysmenorrhea usually begin?

A

in adulthood

46
Q

What is the difference in cause for primary vs secondary dysmenorrhea?

A

primary is not due to underlying gyn structural d/o.
(increased uterine contractions, passage of tissue through os, narrow os, lack of exercise)
secondary is usually due to underlying pelvic AbN (endometriosis, fibroids, adenomyosis)

47
Q

What are some good questions to ask to differentiate btw primary and secondary dysmenorrhea?

A
age of onset
nature and severity
factors that relieve/worsen
degree of disruption of daily life
presence of pelvic pain unrelated to menses
effects of contraceptive on pain
48
Q

red flags: dysmenorrhea

A

new/sudden onset of pain
unremitting pain
fever
vaginal d/c

49
Q

What are the first tests to do for dysmenorrhea? And what if those come out inconclusive?

A

Pg, TVUS, culture
then, SIS or HSG
then, MRI
if all of above inconclusive….hysteroscopy

50
Q

What is the pattern of PMDD?

A

sever PMS sxs occurring only during the 2nd half of cycle and ending with onset of menses or shorty after

51
Q

What are some key sx features of PMDD?

A

suicidal thoughts
decreased interest in daily activities
sxs are severe enough to interfere with daily activities

52
Q

How do you Dx PMS or PMDD?

A

clinically
PMS: 2-3 month PMS diary
PMDD: diary for at least 2 cycles
Must have: feelings of sadness/hopelessness, anxiety, emotional liability with frequent tearfulness, irritability/anger, loss of interest in daily activities

53
Q

DDX: PMDD

A

thyroid disease
other hormonal d/o’s
affective d/o’s

54
Q

What is the underlying issue with PCOS?

A

the woman’s inability to process insulin in the liver and muscles due to probable genetic susceptibility that causes hyperinsulinemia

55
Q

When do sxs start with PCOS?

A

menarche and worsen with time

56
Q

What is the classic PCOS presentation?

A
irregular menses
hirsutism, acne, temporal balding
acanthosis nigricans
obesity
m/b enlarged ovaries/cystic ovaries
57
Q

What are some serious sequelae if PCOS goes untreated?

A
CVD
DM
metabolic syndrome
endometrial carcinoma
m/b breast CA
58
Q

What does PCOS look like on TVUS?

A

string of pearls: multiple follicles 2-9mm on periphery of ovary

59
Q

What is require for DX of PCOS?

A

2 of 3:
ovulatory dysfunction = menstrual irregularity
clinical/biochemical evidence of hyperandrogenism
more than 10 follicles per ovary on TVUS

60
Q

What two tests would you do to r/o Cushing’s Syndrome and adrenal virilism when you suspect PCOS?

A

serum cortisol

fasting serum 17-hydroxyprogesterone

61
Q

What are some etiologies of premature ovarian failure?

A

AI
chemo
cigarette smoking

62
Q

Sxs: premature ovarian failure

A

amenorrhea/irregular bleeding

sx of estrogen deficiency

63
Q

Which tests are diagnostic for premature ovarian failure?

A

serum FSH, estradiol (if FSH is >20)

64
Q

What is considered premature menopause? Give 3 reasons why this might occur

A

before the age of 40

high altitude, smoking, undernutrition

65
Q

What is the hallmark of perimenopause?

A

changes in bleeding patterns with menses usually beginning in 40s

66
Q

Ssx: menopause

A
hot flashes/sweating
vaginal dryness
neuropsychiatric changes
night sweats
light-headedness, palpitations, numbness, tingling
atrophic changes
GI disturbances
lack of libido
67
Q

What are 3 health problems associated with menopause?

A

osteoporosis
CVD
breast CA

68
Q

What are three risk factors for osteoporosis?

A

smoking
sedentary lifestyle
wt. less than 127lbs. or BMI<21

69
Q

What is the classic presentation of vaginitis?

A

abnormal vaginal d/c
irritation
pruritis
erythema

70
Q

What makes d/c AbN?

A

offensive odor
prutitis
burning/pain
copious

71
Q

What does d/c look like when cancerous?

A

watery, bloody or both

72
Q

3 causes of vaginitis in young girls

A

chemicals
foreign bodies
infection

73
Q

what is the main cause of vaginitis in reproductive age women?

A

infection

74
Q

When is inflammatory or atrophic vaginitis most common?

A

in menopausal women

75
Q

What do you want to know, specifically, when a woman comes in with vaginits?

A

Antibx use
immunosuppressive d/os
hx of fistulas
sexual practices and hx

76
Q

What 4 PEs should you do for vaginitis?

A

palpate inguinal LNs
external genital exam
bimanual
vaginal pH

77
Q

red flags: vaginitis

A

trichomonal vaginitis in children

fecal d/c (fistula)

78
Q

What else could cause sxs that look like vaginitis? Name 4

A

UTI
allergy/irritation
derm dz
paget’s dz

79
Q

Risk factors for BV. Name 5

A
IUD
Low vit. D
poor nutrition
douching
no condom use
anal sex before vaginal sex
spermicides
smoking
80
Q

What are the hallmark sxs of BV?

A

fishy odor to d/c
profuse, thin white gray d/c that coats tissue
pruritis and irritation

81
Q

What is uncommon with BV?

A

erythema and edema

82
Q

What are the dx criteria for BV?

A

gray d/c
pH >4.5
fishy odor
clue cells

83
Q

Do WBCs go up with BV?

A

no

84
Q

Risk factors for candida.

A
antibx use
pregnancy
constrictive undergarments
UD
DM
85
Q

What is the d/c like with candida?

A

thick, white, cottage-cheese like
adheres to vaginal wall
pH<4.5

86
Q

When do sxs often increase with candida?

A

a week before menses

87
Q

How do you dx atrophic/inflammatory vaginitis?

A

ph>6
wet prep: increased WBCs, decrease lactobacillus, parabasal cells
m/b increased cocci

88
Q

What are the sxs of atrophic/inflammatory vaginitis?

A

clear or purulent d/c
dyspareunia, dysuria, irritation
itching, erythema, burning, minor bleeding
thin dry mucosa

89
Q

What is the d/c like with trich?

A

copious yellow/green and frothy!

90
Q

What might the walls and surface of the cervix look like with trich?

A

strawberry/punctate red

91
Q

how does one dx trich?

A

pH: >5.5

wet prep: increased WBCs, flagellated trichomod

92
Q

What are the sxs of cytolytic vaginosis?

A
burning, pruritis
rawness
vulvovaginitis
dyspareunia
erythematous and excoriated tissue
93
Q

Dx of cytolytic vaginosis

A

pH normal or <3.5

wet prep: small amount of WBCs, increased rods, false/atypical clue cells

94
Q

What are the two most common causes of PID?

A
Neisseria Gonorrhea (GC)
Chlamydia trachomatis
95
Q

What is the most common cause of PID in women >35?

A

overgrowth of anaerobic/aerobic bacteria in vagina that ascend

96
Q

What are common risk factors for PID in adolescents?

A

with older sexual partners
hx of child protective sercives involvement
hx of attempted suicide (wah???)

97
Q

Of gonorrhea and chalmydia, which causes more severe PID sxs?

A

gonorrhea

98
Q

Sxs: PID

A
low ab pain that radiates to the back
fever
d/c
AUB
onset during or after menses
dysuria
N/V
99
Q

What will you find on PE with PID?

A
inguinal LAD, tender
fever 101 or greater
increased pulse rate
speculum: red cervix, easily friable
mucopurulent d/c, yellow/green from os
CMT, guarding/rebound tenderness, enlarged skene's glands, uterine and adenexal tenderness
100
Q

how would you confirm/negate PID?

A

wet prep: >10 WBCs/hpf
CBC: elevated WBCs
ESR: increased >15mm/hr
If all negative, not likely PID

101
Q

What are the main complications of PID (know these fo’ reals)?

A

Tubal scarring and adhesions: chronic pelvic pain, menstrual irregularities, infertility and increased risk for ectopic pg

102
Q

3 DDx for PID

A

endometriosis
appendicitis
ectopic pg

103
Q

What does the d/c of gonorrhea look like?

A

yellow/green mucopurulent

104
Q

What is the pattern of labs associated with gonorrhea?

A

inc. pH
inc. WBCs
inc. ESR
positive culture, of course.