Gyn Flashcards
Name most common etiologic causes of 2e amenorrhea (2)
- Ovarian causes—40%
- Hypothalamic causes—35%
Describe tx: Primary Ovarian Insufficiency (3)
- Patient education (diagnosis)
- Hormone replacement therapy until age of menopause
- Maintain age-appropriate bone density
- Cardiovascular health
- Yearly F/U of HRT, TSH levels; bone scan as needed
Describe tx: Primary dysmenorrhea (3)
- NSAIDs
- Hormonal suppression (OCPs, Depo-Provera, Mirena)
- Nonpharmacologic (i.e., physical exercise, topical heat, high- frequency transcutaneous electrical nerve stimulation (TENS))
Describe steps for primary amenorrhea (3)
- B-hcg
- Pelvic ultrasound
- Serum levels of FSH
In amenorrhea, if present + high FSH, think of what? (2)
- Gonadal dysgenesis: Turner Syndrome, Swyer syndrome
- 17 alpha hydroxylase deficiency
Describe: Gonadal dysgenesis (3)
- Present streak gonads, functionless, fribrous tissue, can’t respond to FSH stimulation
- Can’t produce sex hormones -> no 2e female sex characteristics
- Associated with Turner’s syndrome and Swyer syndrome
How to dx: Turner’s syndrome
- Karyotype: 45X or Mosaic (45X + 46XX OR 45X + 46XY)
Describe presentation: Turner’s syndrome (6)
- Short stature
- Widely spaced nipples
- Low-set ears
- Wide or webbed neck
- Broad chest
- Arms turn outward
Describe tx: Turner’s syndrome (3)
- Streak gonads surgically removed
- Estrogen therapy (low doses) + progesterone (2 yrs after) 10 days per month to induce menstrual bleeding
- Growth hormone therapy
Describe lab: 17 alpha hydroxylase defiency (3)
- high progesterone
- high deoxycorticosterone
- serum 17-alpha-hydroprogesterone < 0.2 ng/ml
Describe tx: 17 alpha hydroxylase defiency (3)
- Exogenous glucocorticoid replacement therapy (hydrocortisone or dexamethasone)
- Mineralocorticoid receptor blockade (ex: spironolactone)
- Low-dose estrogen + progestin (2 yrs later)
DDX of uterus on pelvic ultrasound + low FSH (2)
hypothalamic or pituitary disorder
- congenital GnRH deficiency (ex: Kallman syndrome)
- constitutional delay of puberty
Name DDX of anatomic abnormality in pelvic ultrasound (for amenorrhea) (2)
- Outflow tract obstruction -> surgery
- Transverse septum (inside vagina)
- Imperforate hymen
- Absent uterus
Name DDX: Absent uterus (3)
- Mullerian agenesis (46XX - genetically female)
- Complete androgen insensitivity syndrome (46 XY)
- 5-alpha reductase deficiency (46 XY)
How to differenciate DDX: Absent uterus (2)
Karyotype + serum testosterone
- Mullerian agenesis (46XX - genetically female)
- Complete androgen insensitivity syndrome (46 XY)
- 5-alpha reductase deficiency (46 XY)
Describe sx: Mullerian agenesis (5)
- 46XX - genetically female
- Short vagina
- absent/rudimentary and obstructed uterus
- ovaries N, breast N
- Development/FSH/Testosterone
Describe tx: Mullerian agenesis (3)
- Psychological counceling
- Surgical creation of vagina + vaginal dilators
- Possible to have children via assisted reproduction techniques (egg harvesting, in vitro fertilization, surrogate pregnancy) OR uterus transplantation
Describe: Complete androgen insensitivity syndrome (5)
- Defective receptor, Testosterone N
- No tissues response:
- Female external genatalia
- Sparce body hair
- Almost no pubertal acne
- Well-developed breats
Describe management: Complete androgen insensitivity syndrome (3)
- Testes in abdomen/pelvis/inguinal canal -> high risk of cancer -> surgical removal after puberty
- Counceling
- Vaginal surgery/dilation
Describe: 5-alpha reductase deficiency (3)
- Do not undergo DHT-dependent masculinization during fetal development
- at birth: female or ambiguous external genitalia
- at puberty: testosterone levels rise ++ -> male-pattern hair growth, acne, muscle mass, deeper voice
Describe management: 5-alpha reductase deficiency (2)
- Counceling
- DHT therapy (if male) or estrogen therapy (if female)
Name initial lab studies for secondary amenorrhea (5)
- FSH
- Prolactin
- Estradiol
- TSH
- If signs of virilization -> testosterone
Descrive tx, dx: Prolactinoma (2)
- IRM
- Tx: Cabergoline (Dopamine agonist) -> inhibits prolactine secretion
Describe signs and tx: Polycystic ovarian syndrome (PCOS) (6)
- Lab: Testosterone > 60 ng/dL + Signs of virilization
- Oligomenorrhea or amenorrhea
- Obesity, insulin resistance -> metformin therapy, weight loss
- Hyperandrogenism -> OCP (if no desire to be pregnant), ideally progestin w/ antiandrogen properties (ex: drospirenone) -
- spironolactone if OCP C-I
- If desire pregnancy -> clomiphene citrate
- If androgen levels +++ > 150 ng/dL -> CT Scan abdomen and pelvis to look for androgen secreting tumours
In secondary amenorrhea, what to think of if normal TSH/prolactin/androgen and:
- High FSH + low estradiol in female < 40 years old
Primary ovarian failure
Describe sx: Primary ovarian failure (2)
- Hot flashes
- Vaginal dryness
Describe tx: Primary ovarian failure (2)
Tx: Hormone replacement therapy
- Estrogen: to decrease risk osteoporosis and Cardiovasc disease
- Progesterone: to decrease endometrial hyperplasia and cancer
In secondary amenorrhea, what to think of if normal TSH/prolactin/androgen and:
- Low FSH + low estradiol in female
- Functional hypothalamic amenorrhea
- Systemic illness (ex: DB1, celiac disease)
- Large tumor that compresses FSH and LH secreting neurones -> IRM
- Pituitary gland
- CNS
In secondary amenorrhea, what to think of if normal TSH/prolactin/androgen and:
- FSH and estradiol normal
Uterus is not responding
- Asherman syndrome: scar tissue in uterine cavity
Describe dx: Asherman syndrome (2)
- golden standard: hysteroscope
- 10-day medroxyprogesterone test to access uterine function
- if bleeding -> healthy uterus
- if no bleeding -> scar tissue in uterine cavity -> hysterosalpingogram or hysteroscopy
What’s the tx of primary dysmenorrhea (2)
- Non pharmacological treatment:
- Reassurance
- Topical heat
- Physical exercise
- • High-frequency TENS
- OCP or NSAIDs
What’s the tx of leiomyomas (2)
Myomectomy or uterine artery embolization
Describe tx: PMS and PMDD
- Non pharmacologic
- Patient education
- Diet: avoid; Na+, simple sugars, caffeine, alcohol
- Supplements—CaCO3, Mg2+, Vit E
- Exercise
- Psychotherapy (CBT)
- Relaxation therapy
- Pharmacological
- NSAIDS (ex: naproxen)
- SSRIs (citalopram, fluoxetine, sertraline)
- Combined OCPs
- Spironolactone (during luteal phase only)
Name C-I for OCPs (14)
- < 6 wk postpartum if breast-feeding
- Breast CA (current)
- Smoker > 35 y.o. (> 15 cigarette/d)
- Uncontrolled HTN (systolic > 160 mm Hg or diastolic > 100 mm Hg
- Venous thromboembolism (current or Hx)
- Ischemic heart disease
- Valvular heart disease (PulmHTN, A b, Hx of SBE)
- Diabetes with retinopathy/nephropathy/neuropathy
- Migraine headaches with focal neurologic Sx
- Severe cirrhoris
- Liver tumor (adenoma or hepatoma)
- Undiagnosed vaginal bleeding
- Known thrombophilia
- Known or suspected pregnancy
Name progestin only OCPs (2)
- Progestin-only pill
- Depo-Provera injection
Name side effects: OCP (5)
Most resolve in first 3 cycles:
- Breast tenderness
- Nausea
- Irregular bleeding
- Chloasma
- No evidence for weight gain and/ or mood Ds
Name criterias for Good Candidates for p Only (8)
- CI or sensitivity to E
- > 35 yr and smoker
- Migraine headaches
- Breast-feeding
- Endometriosis
- Sickle cell disease
- Anticonvulsant Rx
- Difficulty complying with daily pill (for DMPA)
Name side effects: Copper IUD (3)
- Pelvic pain
- ↑ Menstrual ow
- Spotting