GYN Flashcards
Cervical Screening
Age <21: no screening regardless of 1st coitus age
- Age 21-29: cytology q.3 yrs w/o HPV co-test
- Age 30-65: co-test q.5 yrs (cytology+HPV) or cytology q.3yrs.
- Age 65+: No further testing if 3 prior negative cytologies or 2 negative prior co-tests
Cervical HPV
16, 18
95% related
Cervical LN Risk
IB: 15% P 10% PA
II: 30% P 20% PA
III: 45% P 30% PA
Cervical H/P script
I would start with a complete history and physical focusing on the presenting symptoms as well as the GYN history including any **prior abnormal Pap smears**, abnormal vaginal bleeding or discharge, and pelvic pain. I would also ask about Sexual, Social and Family History.
I would then perform a full physical exam including LN palpation for inguinal and **supraclavicular nodes**. I would perform an abdominla exam followed by pelvic exam consisting of speculum, bimanual, and rectovaginal exam (to evaluate the **cervical os, cervical mass, vaginal vault size, vaginal extension, parametrium, pelvic side wall extension, adexa, and uterus**) and PAP Smear.
Cervical Workup
Labs: CBC with diff, CMP, LFTs, HIV, pregnancy test
Imaging (IB2+)
- PET/CT or CT
- MRI – smudgy border = parametrial invasion
- cystoscopy and sigmoidoscopy if suspicion for bladder/bowel
Biopsy:
- EUA with gyn onc
- Colposcopy w biopsy. If no gross lesion noted, conization.
**If stage > IIIB: RENAL STENT prior to definitive chemoRT (creat > 3 → no cis!)
Fertility Evaluation (egg harvesting) and oophoropexy
Cervical Staging
IA1: <3mm depth
IA2: 3-5mm
IB1 – macro < 2 cm (and >5 mm depth)
IB2 – macro 2-4 cm
IB3 – macro > 4cm (bulky!)
IIA1: upper 2/3 vagina < 4cm: (small size therefore group with IB1 for tx)
IIA2: upper 2/3 vagina > 4cm
IIB - parametria
IIIA – lower 1/3 vagina
IIIB – pelvic SW, hydro, kidney dysfunction
IIIC1 – pelvic nodes
IIIC2 – PA nodes
IVA/T4: bladder, rectum, or beyond true pelvis
IVB/M1: distant organs
TAH
uterus, cervix, and small rim of vagina cuff
Mod radical hyst
uterus/cervix/1-2 cm of vagina, some of parametrium
Radical hysterectomy
uterus/cervix/upper 1/3-1/2 of vagina, dissection of parametrium to sidewall, PA/pelvic LND
Rad trachelectomy –
removes cervix, parametria + LN sampling
- Preserves fertility.
- Only for tumor < 2 cm, no LVI (not meeting Sedlis!)
Cervix 1A1 no LVI treatment
(only group not needing nodal management)
1) Cold knife cone, if negative margins, then simple hysterectomy (if fertility not desired)
2) Fertility sparing: CKC (want margins ≥3mm, no LVI) if positive margins repeat cone or trachelectomy
3) Inoperable: definitive brachy (7.5 x5)
Cervix IA2
1) Mod rad hyst + pelvic LND/SNB > risk stratified RT/CRT (Sedlis/Peters)
2) Fertility sparing: Rad trach + PLND/SNB, or CKC with neg margins and PLND/SNB
3) Definitive RT (pelvic RT+brachy, 75Gy)
Cervix IB1-2 and IIA1
1) Rad hyst + PLND + PA sampling > risk stratified RT/CRT (Sedlis/Peters)
2) Last fertility sparing option for IB1, up to 2cm, no LVI, path node neg: rad trachelectomy+ PLND/SND
3) Definitive RT (80+Gy)
Cervix IB3, IIA2+
Cervix IB3, IIA2+ ie >4 cm or advanced
CRT ->brachy boost
Cervix Post op Whole Pelvis RT indications
Sedlis 2 of 3 factors:
LVSI
> 4cm
>1/3 stromal invasion
Cervix Post op Chemo RT
(Peters)
Positive margins (<3 mm)
Positive nodes
Parametrial inv (surprise FIGO IIB)
Cervix interstitial indications
- tumor >4cm after EBRT (poor responder)
- residual tumor extends to lateral parametria or sidewall (redundant with above)
- extensive or distal vaginal involvement
- narrow distorted vagina that would not accommodate applicator
Cervix finish treatment within
8 weeks
cervix chemo
Cisplatin: 40 mg/m^2 weekly
Cervix Simulation
SIM:
- 3DCRT (4-field box) positioned prone on belly board
- IMRT: extended field, or SIB to nodes, supine
- CT sim, IV and small bowel contrast
- anal marker
- gyn marker: vaginal if post-op, if intact fiducial to mark extent of vaginal disease
- full bladder, empty rectum (IMRT – full and empty bladder scan – to generate uterus and cervix ITV)
Cervix pelvic targets
Targets (definitive or postop):
- gross disease (cervix and entire uterus if definitive), vagina, parametria/uterosacrals, and pelvic LN
- always: Pelvic LN: obturator, internal/external iliac, presacral
- Cover common iliacs if pelvic LN + (to bifurcation of aorta)
- Extended field to level of renal vessels (or higher, ~5cm above highest LN) if common iliacs or PA involved
- Inguinal nodes if IIIA (distal vagina involved)
IMRT? indicated for SIB to gross nodes, extended field, or postop (TIME-C trial for postop cervix and endometrial, IMRT reduced pt reported acute GI and GU toxicity). Otherwise, prob safest to say 3DCRT.
*parametria positive – 45, then boost parametria to 54
3DCRT fields (postop or definitive): All to 45 Gy (50.4Gy if EBRT alone)
Cervix
AP/PA:
sup: L4/L5 at int/ext iliac nodes (bifurcation of common iliacs)
- if pelvic nodes +, tx common iliac nodes (L3/4 – bifurcation of aorta)
inf: 3 cm below inf vaginal inv or inferior obturator (whichever is lower)
lat: 2 cm on pelvic brim (don’t block SI joints or femoral head)
Lat field:
- anterior: 1 cm anterior to pubic symphysis
- posterior: entire sacrum (don’t split!)
Cervix Nodal Boost
- Nodes <2cm à 60 Gy (SIB in 25 fractions to 54-56 Gy/2.16-2.24Gyfx à sequential boost in 2 Gy fx to 60Gy) – wait to do sequential dose until after brachy
- Nodes >2cm à 63Gy or higher depending on OARs (usually limited by bowel dose); as above, do SIB to 54-56Gy in 25 fx then sequential bode post to 63Gy
- Don’t forget brachy throw-off (important for obturator nodes, get about 1 Gy/fx)
Cervix post op dose
Post-op
- Treating for Sedlis criteria, negative margins and negative LN: 45 Gy to pelvis
- Treating for Positive margins: 45 Gy to pelvis, parametrial boost as above to 54 Gy, vaginal cylinder boost 4Gy x 3 to surface (EQD2 62.4-67Gy) – goal 60-66Gy to areas of concern for positive margins
Parametrial Boost – 54 Gy, if involved, with IMRT
-3D borders – AP/PA – lower sup border to bottom of SI joint, 4-4.5 cm wide midline block – all other borders stay the same
Cervix Treatment flow
CRT - > exam/MRI at 4 weeks -> Brachy twice weekly after EBRT separated by 72 hours, finish all in 8 weeks
cervix Brachy script
Applicator selection: T&O – safe to say
- in OR, anesthesia à dorsal lithotomy position
- EUA: primary, parametria, rectovaginal septum, mucosal involvement; select T&O size
- place fiducials to mark any vaginal disease and at cervix to evaluate applicator placement – at cervix, inferior extent of vaginal involvement
- place foley in bladder
- sound uterus (to determine tandem length)
- serially dilate cervical os under US guidance
- place tandem and ovoids (want snug fit – largest possible ovoids)
- set flange at end of uterine cavity
- pack: start posterior, then anterior
- insert dummy wire into tandem
- image: CT scan or film – to ensure placement
- fuse to diagnostic MRI for contouring guidance
*each fraction separated by at least 72 hrs*
Film evaluation:
Anterior
- Tandem bisects ovoids
- Tandem not rotated
- Flange close to marker seeds
- Ovoids high in fornices <1 cm from marker seeds, with ~1 cm spacing between them
Lateral
- Tandem bisects ovoids, not rotated
- Tandem midway between sacrum & bladder, at least 3 cm from sacral promontory
- Packing is ant & post to ovoids, but not sup to ovoids
- Foley balloon pulled down
Cervix Brachy Volumes
- contour on T2 based sequences, fuse diagnostic MR to planning CT
- HRCTV= entire cervix, GTV w/ parametrial/vaginal/uterine extension at time of brachy
- IRCTV=HRCTV+ 0.5-1.5cm (excluding OARs) + also includes initial extent of disease; should get 60% of Rx
Dose: HDR 1;5.5 Gy x 5, Ir-192, dose rate 12 Gy/hr (~equal to 35-40 LDR). 80-85 Gy EQD2 total
Points (images at end of sheet):
A: 2cm superior to cervical OS and 2cm lateral (uterine vessels cross ureter)
B: 3cm lateral to point A (parametrium/ obturator); receives 33% point A dose
C: 4cm lateral to point A (sidewall), 20% dose
Bladder – posterior surface of foley balloon on lat and center on AP film
Rectal – 5mm behind posterior vag wall between ovoids
Vaginal point – AP film lateral edge of ovoid, Lat – mid-ovoid
Cervix HDR goals
Target
D90 > 100% Rx (>80-85Gy EQD2)
Point A >65Gy (for CT/MR guided/optimized brachy)
Cervix OAR constraints
- Small Bowel: D2cc <55-60Gy EQD2
- Rectum: D2cc <65Gy EQD2
- Sigmoid: D2cc <70Gy EQD2
- Bladder: D2cc <80Gy EQD2
- Cumulative:
- Vagina:
- -upper < 120 Gy
- -mid < 80 Gy
- -lower < 60 Gy
- Fem head < 45
Cervix not meeting normals
- Check packing
- Replan
- Change fractionation (use more fractions, lower dose per fraction)
Cervix Side effects
Vaginal stenosis with 50-60 Gy
Side effects
Acute: cystitis, diarrhea, vaginal discharge, dysuria, decreased counts
Late: Vaginal stenosis, stricture, fibrosis, ureteral stricuture, cystits, SBO, proctitis, thinning mucosa, ovarian failure, painful intercourse, femoral neck fx (5%)
Tandem specific:
Uterine perf (<3%), vaginal laceration (1%)
Cervix 5 year OS
IA - 90%
IB - 80%
II - 60%
III - 30%
IV - 10%