Gut Motility And Acid Secretion

Question 0

Give two example of dopamine D2 receptor antagonists.

Answer 0

• Domperidone

- Metaclopramide

Question 1

What are the five classes of anti-emetic drugs?

Answer 1

• Dopamine D2 receptor antagonists
• 5-HT3 receptor antagonists
• Anti-muscarinics
• H1 receptor antagonists
• Other agents

Question 2

What is the MoA of D2 receptor antagonists?

Answer 2

Acts on the postrema on the floor of the fourth ventricle (vomiting centre).

Question 3

What is the MoA of Domperidone?

Answer 3

Acts of the postrema of the floor of the fourth ventricle and also promotes gastric emptying.

Question 4

Name an ADR associated with Domperidone.

Answer 4

Galactorrhoea due to increased prolactin release.

Question 5

What is the MoA of Metaclopramide? When is it indicated?

Answer 5

• Acts on the postrema on the floor of the fourth ventricle.
• Has some anti-cholinergic effects
• Blocks vagal afferents
• First line therapy

Question 6

What ADRs are associated with Metaclopramide?

Answer 6

Extra-pyramidal effects such as . Therefore must be avoided in PD.

Question 7

Name two classes of antacids

Answer 7

• H2 receptor antagonists

- Proton pump inhibitor

Question 8

Name two H2 receptor antagonists

Answer 8

• Cimetidine

- Renitidine

Question 9

Name two PPIs

Answer 9

• Omeprazole

- Lansoprazole

Question 10

How do PPIs work?

Answer 10

Block the action of the proton pump in canaliculi, preventing acid secretion.

Question 11

How to H2 receptor antagonists work?

Answer 11

Block the action