Gustation Flashcards

1
Q

which papillae posses taste buds

A

circumvallate, fungiform and foliate

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2
Q

each circumvallate papillae has ______ taste buds in the ______

A

250 taste buds in the trench

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3
Q

each fungiform papillae has ____ on the ___________

A

3 taste buds on the apical surface

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4
Q

foliate papillae are organised into _______ with ____ taste buds

A

parallel ridges with 600 taste buds

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5
Q

the dorsal surface of the tongue is composed of four types of papillae

A

fungiform, circumvallate, foliate and filiform

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6
Q

circumvallate papillae get special afferent taste innervation from ____

A

cranial nerve IX (the glossopharyngeal nerve)

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7
Q

a single taste bud can contain up to ___ specialised epithelial cells (taste cells)

A

50

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8
Q

the tips of taste cells have what that increases surface area and helps concentrate chemicals onto taste receptor proteins to amplify the signal

A

microvilli

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9
Q

what are the 5 basic tastes

A

bitter, sour, sweet, salt, umami

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10
Q

what components make up a taste bud

A

microvilli, pore, gustatory cell, basal cell, support cell

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11
Q

what receptor proteins do the apical microvilli contain?

A

ion channels: salt & sour(acids)

GPCR: sweet, bitter & umami

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12
Q

what are the neurotransmitters involved?

A

serotonin and ATP

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13
Q

where do taste cells synapse onto

A

cranial nerves: facial VII, glossopharyngeal IX and vagus X

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14
Q

why can’t 25% of the population detect bitter

A

they have an inability to sense phenylthiocarbamide (PTC) due to a lack of T2R receptor gene

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15
Q

what ion channels are involved in salt sensing

A

amiloride-sensitive Na+ channels

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16
Q

what ion channels are involved in sour (acids) sensing

A

H+ sensitive TRP channel (PKD variant)

17
Q

what receptor channels are involved in sweet and umami sensing

A

T1R (GPCR) - can form heterodimers

18
Q

which tastes cause direct or indirect depolarisation of the taste cell

A

Salt and sour = direct depolarisation

Sweet, umami and bitter = indirect depolarisation

19
Q

what heterodimer is responsible for sweet detection

A

T1R2/T1R3

20
Q

what heterodimer is responsible for umami detection

A

T1R1/T1R3

21
Q

what other receptor detects umami

A

metabotropic glutamate receptor 4

- taste mGlu4

22
Q

what receptor is involved in bitter taste

A

T2Rs

23
Q

specific type of alpha protein involved in bitter taste is what

A

alpha gustducin

24
Q

what do GPCRs signal through

A

PLCbeta2 TRPM5 pathway

25
Q

what gives us our perception of food by integrate lots of sensory information

A

the orbitofrontal cortex

26
Q

what cortex is involved in signalling satiety

A

the orbitofrontal cortex